The group is currently addressing, in particular, application, medicinal and chemico-biological issues of selected natural substances. We deal with the isolation of natural products from natural materials and the preparation of analogues of medically popent substances. The products of our work are intended for testing a specific biological activity or application potential in (bio)analytical methods.
Our main portfolio includes chemistry of steroid compounds (estradiol, androgens, cardiotonics), mitotic inhibitors (colchicine, taxol, vinblastine), SERCA inhibitors (trilobolide and thapsigargin), antimalarials (artemisinin) and maturation inhibitors of HIV-1 (bevirimat).
The group also focuses on the synthesis of fluorophores and fluorescently labeled natural substances. Our favorite fluorophores include BODIPY, but we also work with cyanine and xanthene dyes. These products are useful tools for studying the fate of natural substances in living cells using fluorescence microscopy.
The fringe thematic aim of the group is the synthesis of ligands intended for labeling with radioactive nuclides. We are currently focusing on ligands for P2X7 and σ-1 receptors. These derivatives are potentially useful in medical imaging techniques such as PET or SPECT.
The link to the publications representing the results of our work is located in the box on the right.