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Researcher ID: F-1138-2017, ORCID ID: 0000-0001-7585-6004 |
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Education |
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2000-2005 |
Master's degree |
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UCT Prague |
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Dpt. of Chemistry of Natural Substances |
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Thesis topic: Synthesis of polyhydroxylated chiral aldehydes as reactants of the aldol reaction |
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Supervisor: doc. Ing. Ladislav Kniežo, CSc. |
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2005-2010 |
Ph.D. study |
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UCT Prague |
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Dpt. of Chemistry of Natural Substances |
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Dissertation topic: Stereoselective synthesis of disaccharide analogues |
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Supervisor: doc. Ing. Ladislav Kniežo, CSc. |
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2010-2012 |
Postdoctoral internship |
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Biochemistry and molecular biology, IOCB AS CR, v.v.i. |
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Supervisors: doc. RNDr. Jan Konvalinka, CSc. and prof. RNDr. Martin Kotora, CSc. |
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2021
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habilitation in the field of Organic Chemistry |
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UCT Prague |
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Title of habilitation thesis:
Synthesis of C-glycosides and C-disaccharides
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Positions |
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2012 - 2021 |
assistant professor at the Institute of Chemistry of Natural Substances, UCT Prague |
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2022 - until now |
associate professor at the Dpt. of Chemistry of Natural Compounds, UCT Prague |
Teaching |
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Stereoselective synthesis |
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Structure and reactivity |
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Bioorganic chemistry of natural substances |
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Bioorganic chemistry of carbohydrates and nucleic acids |
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Semester work Chemistry of natural substances |
Research activity |
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| Organocatalysis, photocatalysis, chemistry of carbohydrates and glycomimetic (C- and S-glycosides/oligosaccharides, galectin inhibitors | |
Internships |
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2004 |
Work placement within the Erasmus program |
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Chimie des hétérocycles et glucides, Blaise Pascal University, Clermont-Ferrand, France |
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Supervisor: prof. Yves Troin |
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2008 |
Work placement |
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Department of Chemistry and Biochemistry, University of Colorado, Boulder, USA |
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Supervisor: prof. Josef Michl |
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2010-2012 |
Postdoctoral internship |
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Biochemistry and molecular biology, IOCB AV ČR, v.v.i. |
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Supervisors: doc. RNDr. Jan Konvalinka, CSc. and prof. RNDr. Martin Kotora, CSc. |
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Projects handled at the moment |
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2022-2024 |
team member, GAČR, no. 22-17586S |
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15N isotopic labeling in NMR structural analysis of N-disaccharides |
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2018-2022
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team member, OPVVV, Reg. no. CZ.02.1.01/0.0/0.0/16_025/000739716_025/0007397_01
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Center for Recombinant Biotechnology and Immunotherapeutics |
Projects solved |
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2017-2021
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co-investigator, Gilead Sciences Research Center |
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Enzymatically stable galectin inhibitors
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2017-2021
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team member, GACR, no. 15-17572S |
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Calix[4]arene/C-oligosaccharide glycocluster design for improved selectivity of interactions with lectins
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| 2012-2014 |
PI, GACR, no. P207/12/P713 |
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A novel Pd-catalyzed modular approach leading to non-hydrolyzable vectors for transfection systems. |
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| 2010-2011 |
team member |
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HIV ACE (Targeting assembly of infectious HIV particles), FP7-HEALTH, project ref. 201095. |
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2005-2010 |
MSMT, grant no. 6046137305. |
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2008-2010 |
Team member, GACR, no. 203/08/1124 |
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Stereoselective synthesis of disaccharide analogues |
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