Instrumentation and Equipment
The Department of Chemistry of Natural Compounds is equipped with modern instrumentation enabling the synthesis, isolation, and detailed structural analysis of biologically active molecules. This technical infrastructure supports research in natural compounds chemistry, bioorganic chemistry, medicinal chemistry, and chemical biology.
The department has facilities for organic synthesis, chromatographic separation, and structural characterization of compounds, including advanced spectroscopic and mass spectrometric methods. Important components of the instrumentation include NMR spectrometers, UHPLC/MS systems, chromatographic apparatus, and other analytical instruments used for the study of the structure and biological activity of natural compounds and their synthetic analogues.
These technologies enable detailed molecular characterization, investigation of interactions with biological targets, and the development of new biologically active compounds with potential applications in medicine, biotechnology, and analytical chemistry.
The instrumentation is used not only for research but also for the education of undergraduate, master’s, and doctoral students, allowing them to become familiar with modern experimental methods already during their studies.
- Autopol VI Polarimeter including software A21831, manufactured by Rudolph Research Analytical. The instrument was acquired through the FRVŠ project No. 612/2009.
- Nicolet iS10 FTIR Spectrometer, manufactured by Thermo Scientific, with a spectral range of 7800–350 cm⁻¹, including control software. The instrument was acquired through the FRVŠ project No. 612/2009.
- Parr 4564 Stirred Pressure Reactor with a 300 mL stainless steel vessel, operating at pressures up to 20 MPa and temperatures up to 350 °C. The system enables continuous sampling, variable stirring speed, and can be controlled either from the panel or by a control unit. The instrument was acquired through the FRVŠ project No. 2898/2011. Contact: Kamil Parkan.
- Biotage 355301 Microwave Reactor with autosampler, operating temperature up to 300 °C, microwave power up to 400 W at 2.45 GHz, and the possibility to work with reaction volumes of 5–20 mL without system modification. The instrument was acquired through the FRVŠ project No. 2898/2011.
- 400 MHz NMR Spectrometer located in the Student NMR Laboratory, acquired jointly by our department and the Department of Organic Chemistry at University of Chemistry and Technology, Prague.
- Agilent UHPLC/MS System consisting of the 6460 Triple Quadrupole and 1290 Infinity LC, located in the Laboratory of Forensic Analysis of Biologically Active Compounds. The instrument was acquired through project CRP C26 (Principal Investigator: Zdeněk Wimmer) with co-funding from Department 342. Contact: Kamil Parkan.
- CombiFlash Rf-200 Automated Flash Chromatography System, located in the Laboratory of Forensic Analysis of Biologically Active Compounds. The instrument was acquired through project MV0/VG20122015075 (2012–2015), Principal Investigator: Kamil Parkan.
- Agilent UHPLC/MS System consisting of the 6550 iFunnel Q-TOF and Infinity 1290 LC, located in the Laboratory of Forensic Analysis of Biologically Active Compounds. The instrument was acquired through grant OP VaVpI 1.05/4.1.00/16.0349 with co-funding from Department 342. Contact: Kamil Parkan.
- Agilent 1200 LC/DIAD System.
- Labconco Lyophilizer.