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                                    [seo_desc] => Studies Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology UCT Prague University of Chemistry and Technology Prague
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We offer an undergraduate bachelor degree program as well as a master degree program in the Czech language only. For information about study programs in English, please visit the university's website.
Study with us 
We offer the research degree program Doctor of Philosophy (PhD) in Organic Chemistry.
Why study for a PhD at our department?
You will become a member of an internationally recognised research team providing high quality research. You will develop the skills and the knowledge needed to pursue your chosen career—in academia, at research organizations, or in public service.
How to apply?
Our prospective student portal provides details about the application process for PhD programmes at UCT Prague. 
Our past graduates
Battaglia Caren Bc. (Master Double Degree)
Abdulmanea Khaled Saleh Omar, MSc., PhD (Yemen): Flavonoids in the Apiaceae family (2012)
Irekhjargal Jambal, MSc., PhD (Mongolia): Inhibitors of galactosyltransferases (2012)
Our present students
Uladzimir Bildziukevich, MSc. (Belarus): Steroid-based compounds with potential pharmacologic importance
Jana Šusteková, Ing. (Slovakia): Self-assembly in supramolecular systems based on steroid compounds
Joint-degree doctoral programme graduates

Ing. Ondřej Jurček, PhD (Czechia): Steroid conjugates for applications in pharmacology and biology (2011), with the Faculty of Mathematics and Science, University of Jyväskylä, Finland
Ing. Helena Heissigerová, PhD (Czechia): Glycosyltransferases: Etude comparative, modelisation moleculaire et synthese de nouveaux inhibiteurs (2003), with the Université Joseph Fourier – Grenoble, France
 
9 We accept students within the framework of the IAESTE exchange programme.
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We are open to cooperation on common projects or through contracts.

We offer our partners:

synthesis of specialty chemicals from natural compounds and their analogs

steroids and other terpeniods
porphyrins
flavonoids
saccharides
glycosides, C-glycosides
non-isotopic labeled compounds



 

prepararion of antibodies, immunogens, tracers and others components of immunoassays
structural analysis
quantitative analysis
consultancy in the development of synhtetic methods
consultancy in the development of analytical methods 
specialty chemicals and immunochemicals from our libraries


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Scientific orientation of the department 

The search for new compounds with novel properties.
Biologically active compounds are our inspiration.


Research topics



Chemistry of steroids and other terpenoids

Prof. RNDr. Pavel Drašar, DSc., EurChem, CChem, CSci, FRSC 




Analytical and bioanalytical methods


Prof. Dr. RNDr. Oldřich Lapčík 




Diagnostic and therapeutic nanosystems


RNDr. Miroslav Ledvina, Ph.D.




Chemistry of triterpenoid supramolecules


Prof. Ing. Zdeněk Wimmer, DrSc.




Structural analysis and molecular modeling


Doc. Dr. Ing. Ivan Raich




Laboratory of forensic analysis of biologically active compounds


doc. Ing. Martin Kuchař, Ph.D.




Chemistry of Saccharides and Glycomimetics


doc. Ing. Kamil Parkan, Ph.D.




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Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, UCT Prague  



k (+420) 220 444 260




Technická 5      


W (+420) 220 444 422




166 28 Praha 6




 




 





Head of Department

 



Prof. Dr. RNDr. Oldřich Lapčík




k (+420) 220 444 448




b Oldrich.Lapcik@vscht.cz




website




CV




room BS18












Secretary of Department





Secretary 




assoc. prof. Ing. Kamil Parkan, Ph.D.


Irena Dražilová




k (+420) 220 444 265


k (+420) 220 444 260




b Kamil.Parkan@vscht.cz


b Irena.Drazilova@vscht.cz




website


 




 CV



building A, room A246

building A, room A244





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                                    [nazev] => The Department of Chemistry of Natural Compounds
                                    [seo_title] => The Department of Chemistry of Natural Compounds
                                    [seo_desc] => The Department of Chemistry of Natural Compounds UCT Prague University of Chemistry and Technology Prague
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The Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology at UCT Prague was founded in 1991 as the successor to the Laboratory of Monosaccharides. Its mission includes both education and training at the graduate as well as postgraduate level and research and development in several fields crossing the frontier between organic chemistry and biology.
Our department's research aims to understand living systems at the molecular level, providing new molecules with new properties that eventually could become medicines, among other things. It is essential to continue this research at the fundamental level so as to provide tools for designing, synthesizing, and evaluating new functional molecules for targeting applications. Nature is our inspiration.
Key research areas include:

Chemistry of steroids and other terpenoids
Chemistry of supramolecules with chiral natural compounds
Synthesis of ligands for the cell-cell recognition
The development of nanosensors for the sensing of pathogenic processes
Analytical and bioanalytical methods
Forensic analysis of biologically active compounds
Chemistry of saccharides and glycomimetics
Molecular modeling


The study of the chemical background of natural processes is a huge adventure, which we ourselves enjoy and wish to share with others. —Oldrich Lapcik, Department Chair

For further details about our research topics, please visit the webpages of individual teams.
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DATA

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    [nazev] => Pavel Drašar
    [seo_title] => Pavel Drašar
    [seo_desc] => Pavel Drašar Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology UCT Prague University of Chemistry and Technology Prague
    [autor] => 
    [autor_email] => 
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Education:


 




1966-71


Charles University Prague, Faculty of Natural Sciences, programme Organic Chemistry




1971-72


Charles University Prague, Faculty of Natural Sciences, postgraduate study, RNDr.




1974-77


PhD study at the Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, CSc.




2004


Scientific degree DSc. awarded by Scientific Council of the Czech Academy of Sciences




Professional life:


 




1971-1972


Assistant professor, Charles University Prague, Faculty of Natural Sciences




1972-2002


Researcher, Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, CSc.




2001-2004


Part-time teacher at Palacky University Olomouc




2002-2004


Associate professor, Department of Chemistry of Natural Compounds, UCT Prague




2004-


Professor, Department of Chemistry of Natural Compounds, UCT Prague




Teaching:


 




 


Selected chapters from Chemistry of natural compounds




 


Special analysis of natural compounds




 


Seminar of molecular modeling




 


Biologically active natural compounds




Subjects of interest:


 




 


Chemistry of natural compounds




 


Synthesis of steroid heterocycles and non-hormone active steroids




 


Isolation and modification of terpenoids




 


Synthesis of supramolecular systems based on chiral natural compounds




Fellowships


 




1974


Institute of Organic Synthesis, Academy of Sciences, Riga, Latvia




1984-5


Arizona State University, Cancer Research Institute, Tempe, Arizona, USA




1987


Institute of Bio-Organic Chemistry, Minsk, Belarus




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Projekty řešené v současné době:

Projekt COST v akci CM1304 Emergence and Evolution of Complex Chemical Systems, 2013-2017
Grant GA ČR 14-04329S Vztah mezi biologickou aktivitou a intracelulární lokalizací seskviterpenových laktonů, 2014-2016
Grant ESF CZ.1.07/2.3.00/30.0060 Propojení výzkumu a vzdělávání v oblasti medicinální chemie, 2013-2015
Grant GA ČR P106/12/0569 Membránové separace - efektivnější separace čistých enantiomerů z racemických směsí, 2012-2015.
2015 Grant Programu bezpečnostního výzkumu České republiky VG20112015045, Vývoj rychlých imunochemických testů pro detekci anabolicky aktivních steroidů, 2011-2015.
Grant fy Contipro Biotech sro 99-103 Syntéza peptidů na nosičích, 2013-2014.

Projekty vyřešené:

Grant GA ČR  P304/10/01951, Nanoliposomy pro vývoj rekombinantních vakcín a cílených imunoterapeutik, 2010-2013.
Projekt Národního výzkumného programu II MŠMT , Supramolekulární materiály na bázi přírodních fytosterolů pro využití v biologii (SUPRAFYT) č. 2B06024, 2006-2011.
Grant NATO na projekt: Development of chemical sensors with tailored sensitivity, č. CBP.EAP.CLG.982972, 2007-2011.
Grant GA ČR  203/06/0006, Syntéza a studium chirálních supramolekulárních synthonů (SSCSS), 2006-2009.
Grant MŠMT  na projekt COST  v akci D-31, Organising Non-Covalent Chemical Systems with Selected Functions, s názvem: Přírodní látky jako modifikátory funkčnosti nekovalentních supramolekulárních systémů II; Natural Products as Function Modifiers in Non-Covalent Supramolecular Systems II (NPFM-II) č. OC08043, 2008-2009.
Projekt COST  v akci D-31: Organising Non-Covalent Chemical Systems with Selected Functions, s názvem: Přírodní látky jako modifikátory funkčnosti nekovalentních supramolekulárních systémů; Natural Products as Function Modifiers in Non-Covalent Supramolecular Systems (NPFM) č. 1P04OCD31.001, 2004-2007.
Výzkumný projekt MZE  QF-3115, DNA-vakcíny, Vývoj vektorů, nosičů a adjuvans pro konstrukci DNA vakcín, 2003-2006.
Rozvojový projekt pro VVŠ MŠMT  č. 605, program 2 podprogram b, Implementace evropských strukturálních prvků ve studiu chemie na VŠCHT Praha a prohloubení účasti VŠCHT Praha v mezinárodních aktivitách směřujících k rozvoji studia chemie v Evropě, 2005.

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Jurášek M, Rimpelová S, Kmoníčková E, Drašar P, Ruml T: Tailor-Made Fluorescent Trilobolide To Study Its Biological Relevance, JOURNAL OF MEDICINAL CHEMISTRY 57, 7947 (2014). DOI: 10.1021/jm500690j
Lorecchio C., Venanzi M., Mazzuca C., Lettieri R., Palleschi A., Nguyen Thi T. H., Cardova L., Drasar P., Monti D.: ORGANIC & BIOMOLECULAR CHEMISTRY 12, 3956 (2014). DOI: 1039/C4OB00134F
Bildziukevich U., Rarova L., Saman D., Havlicek L., Drasar P., Wimmer Z.: STEROIDS 78, 1347 (2013). DOI: 10.1016/j.steroids.2013.10.003
Vinš P, Vermachová M, Drašar P, del Barrio M, Jarne C, Cebolla VL, de Cózar A, Zangi R, Cossío FP: Size and branching effects on the fluorescence of benzylic dendrimers possessing one apigenin fluorophore at the core TETRAHEDRON 69 10361-10368 (2013); http://dx.doi.org/10.1016/j.tet.2013.10.002
Zhylitskaya, H; Litvinovskaya, R; Baranovsky, A; Eigner, V; Kratochvil, B; Drasar, P; Khripach, V: Regio- and stereocontrolled synthesis of novel steroidal isoxazolines: A new route to the formation of selectively modified steroid side chains STEROIDS 78, 823-831 (2013); DOI: 10.1016/j.steroids.2013.04.017.
Mrozek, L; Coufalova, L; Rarova, L; Placek, L; Opatrilova, R; Dohnal, J; Kralova, K; Paleta, O; Kral, V; Drasar, P; Jampilek, J: New polyfluorothiopropanoyloxy derivatives of 5 beta-cholan-24-oic acid designed as drug absorption modifiers STEROIDS 78, 832-844 (2013); DOI: 10.1016/j.steroids.2013.05.012.
Naitana, ML; Dukh, M; Zelenka, K; Trnka, T; Venanzi, M; Lettieri, R; Drasar, P; Monti, D: The kinetic studies of the solvent-promoted aggregation of a steroid-porphyrin derivative JOURNAL OF PORPHYRINS AND PHTHALOCYANINES 17, 889-895 (2013); DOI: 10.1142/S1088424613500831
Jurasek, M.; Rimpelova, S.; Kmonickova, E.; Drasar, P; Ruml, T: Biological relevance of fluorescent trilobolide conjugates FEBS JOURNAL 280, SI/1, 342-342 (2013).
Khripach, VA; Tarkowska, D; Zhabinskii, VN; Gulyakevich, OV; Ermolovich, YV; Drasar, P; Strnad, M: Synthesis and Mass Spectral Fragmentation Patterns of Brassinolide Early Biosynthetic Precursors Labeled at C-26 NATURAL PRODUCT COMMUNICATIONS 8, 771-774 (2013).
Coufalova, L; Mrozek, L; Rarova, L; Placek, L; Opatrilova, R; Dohnal, J; Kral'ova, K; Paleta, O; Kral, V; Drasar, P; Jampilek, J: New propanoyloxy derivatives of 5 beta-cholan-24-oic acid as drug absorption modifiers STEROIDS 78, 435-453 (2013); DOI: 10.1016/j.steroids.2013.02.001.
Jurasek, M; Dzubak, P; Sedlak, D; Dvorakova, H; Hajduch, M; Bartunek, P; Drasar, P: Preparation, preliminary screening of new types of steroid conjugates and their activities on steroid receptors STEROIDS 78, 356-361 (2013); DOI: 10.1016/j.steroids.2012.11.016  
Khripach, VA; Zhabinskii, VN; Konstantinova, OV, Tsavlovskii, DV; Baranovsky, AV; Lyakhov, AS; Drasar, P; Synthesis, crystal structure and NMR investigation of a new type of cyclic steroidal dimer based on brassinosteroids JOURNAL OF MOLECULAR STRUCTURE 1032, 1-4 (2013); DOI: 10.1016/j.molstruc.2012.07.001.
Lettieri R.; Monti D.; Zelenka K., Trnka T., Drašar P., Venanzi M. Glucosylated steroid-porphyrins as new tools for nanotechnology applications NEW JOURNAL OF CHEMISTRY 36, [5], 1246-1254 (2012) DOI: 10.1039/c2nj20982a
Zelenka K., Trnka T., Tišlerová I., Monti D., Cinti S., Naitana ML., Schiaffino L., Venanzi M., Laguzzi G., Luvidi L., Mancini G., Nováková Z., Šimák O., Wimmer Z., Drasar P. Spectroscopic, Morphological, and Mechanistic Investigation of the Solvent-Promoted Aggregation of Porphyrins Modified in meso-Positions by Glucosylated Steroids. CHEMISTRY-A EUROPEAN JOURNAL 17, [49], 13743-13753 (2011) DOI: 10.1002/chem.201101163
Šusteková J., Drašar P., Šaman D., Wimmer Z. Stigmasterol-Based Novel Low Molecular Weight/Mass Organic Gelators Molecules 16, [11], 9357-9367 (2011). DOI: 10.3390/molecules16119357  
Mrozek L., Dvořáková L., Mandelová Z., Rárová L., Řezáčová A., Plaček L., Opatřilová R., Dohnal J., Paleta O., Král V., Drašar P., Jampílek J. Investigation of new acyloxy derivatives of cholic acid and their esters as drug absorption modifiers STEROIDS 76, [10-11], 1082-1097 (2011). DOI: 10.1016/j.steroids.2011.04.014
Nováková Z., Tomanová J., Štěrbová L., Drašar P. Steroid and bile acids amide conjugates with D-glucosamine, COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS 76, [1], 65-74 (2011) DOI: 10.1135/cccc2010105
Čopíkova J., Moravcová J., Lapčík O., Opletal L., Drašar P. Přírodní látky a jejich deriváty chuti chladivé (Natural Compounds with Cooling Taste and Their Derivatives) Chemicke Listy 105, [12], 938-942 (2011).
Lapčík O., Opletal L., Moravcová J., Čopíková J., Drašar P. Přírodní látky a jejich deriváty chuti pálivé (Natural Compounds and Their Derivatives of Hot or Pungent Taste) CHEMICKE LISTY 105, [6], 452-457 (2011).
Štěpánek P., Šimák O. Nováková Z., Wimmer Z., Drašar P.: Asymmetrically substituted calix[4]pyrrole with chiral substituents. ORGANIC & BIOMOLECULAR CHEMISTRY 9 [3], 682-683 (2011).1477-0520.
Svobodová H., Ryšavá H., Pavlík M., Šaman D., Drašar P., Wimmer Z.: Steroid conjugates: Synthesis and preliminary biological testing of pro-juvenoids. BIOORGANIC & MEDICINAL CHEMISTRY 18 [23], 8194-8203 (2010).
Drašar P., Přichystalová T., Wimmer Z., Ledvina M. Drasar L.: Steroidní amidy odvozené od sperminu a způsob jejich přípravy. CZ PV 2010-606 (2010).
Musilová J., Barek J., Drašar P., Peckova K.: Differential Pulse Voltametry of Selected Nitrophenols on Boron-Doped Diamond Film Electrode. SENSING IN ELECTROANALYSIS 4, 135-142 (2009).
Jurcek, O., Wimmer, Z. , Bennettova, B., Moravcova, J., and Drasar, P. Novel Juvenogens ( Insect Hormonogenic Agents): Preparation and Biological Tests on Neobellieria bullata. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 57 [22], 10852-10858 (2009).
Hampl F., Moravcová J., Čopíkova J., Opletal L., Lapčík O., Drašar P.: Krása a diversita přírodních antibiotik (Beauty and Diversity of Natural Antibiotics). CHEMICKE LISTY 103 [1], 15-27 (2009).
Černý I., Buděšínský M., Pouzar V., Drasar P.: Steroids linked with amide bond-Extended cholesterol. STEROIDS 74 [1], 88-94 (2009).
Drašar, P.: O atributech chemického vzdělávání (The attributes of chemical education). CHEMICKE LISTY 103 [5], 371-372 (2009).
Huong N. T. T., Klímková P., Sorrenti A., Mancini G., Drasar P.: Synthesis of spiroannulated oligopyrrole macrocycles derived from lithocholic acid. STEROIDS 74 [8], 715-720 (2009).
Jurček O., Wimmer Z. , Svobodová H., Bennettová B., Kolehmainen E., Drašar P. Preparation and preliminary biological screening of cholic acid-juvenoid conjugates. STEROIDS 74 [9], 779-785 (2009).
Raichyonok T. F., Khripach V. A., Zhabinskii V. N., Konstantinova O. V., Drašar P. B., Monti D.: Synthesis and Spectral-Luminescence Properties of the Conjugate of 24-Epibrassinolide with Porphyrin. JOURNAL OF APPLIED SPECTROSCOPY 76 [4], 542-546 (2009). ZHURNAL PRIKLADNOI SPEKTROSKOPII 76 [4], 571-575 (2009).
Monti D., Venanzi M. , Gatto E., Mancini G., Sorrenti A., Štěpánek P., Drašar, P.: Study of the supramolecular chiral assembly of meso-"C-glucoside"-porphyrin derivatives in aqueous media. New Journal of Chemistry 32 [12], 2127-2133 (2008).
Drašar P., Nguyen T. T. H., Klímková P.: Mono-spiroanelované makrocykly odvozené od lithocholové kyseliny a způsob jejich výroby. CZ PV 2008-367 [300168] (2008).
Drašar P., Trnka T., Zelenka K.: Oligopyrrolové makrocykly substituované v meso-polohách glykosylovanými steroidy a jejich příprava. CZ PV 2008-27 (2008).
Rumlerová-Lipšová A., Barek J., Drašar P., Zelenka K., Pecková K.: Polarographic and voltammetric determination of meso-tetrakis(4-sulfonatophenyl) porphyrin tetrasodium salt at mercury electrodes. International Journal of Electrochemical Science 2 [3], 235-247 (2007).
Drašar P., Nguyen T. T. H., Klimková P.: Syntéza methyl (5beta)-3,3-di-1H-pyrrol-2-ylcholan-24-oátu. CZ PV 2007-868 [300167] (2007).
Drašar P., Nguyen T. T. H., Klimková P.: Bis-spiroanelované oligopyrrolové makrocyklů odvozených od lithocholové kyseliny a způsob jejich výroby. CZ PV [300167] 2007-869 (2007).
Opletal L., Čopíková J., Uher M., Lapčík O., Moravcová J., Drašar P.: Přírodní látky hořké chuti (Natural Compounds of Bitter Taste). Chemicke Listy 101 [11], 895-906 (2007).
Štěpánek P., Dukh M., Šaman D., Moravcová J., Kniežo L., Monto D., Venanzi M., Mancini G., Drašar P.: Synthesis and solvent driven self-aggregation studies of meso-“C-flycoside”-porphyrin derivatives, Org. Biomol. Chem., 2007, 5, 960-970.
Lapčík O., Čopíková J., Uher M., Moravcová J., Drašar P., Necukerné přírodní látky sladké chuti (Sweet Non-Saccharide Natural Compounds), Chem. Listy, 2007, 101, 44-54.
Čopíková J., Lapčík O., Uher M., Moravcová J., Drašar P., Cukerná nesacharosová sladidla a příbuzné látky (Non-Sucrose Saccharide Sweeteners and Related Compounds), Chem Listy, 2006, 100, 778-783.
Čopíková J., Uher M., Lapčík O., Moravcová J., Drašar P., Přírodní barevné látky (Natural Colorants), Chem. Listy, 2005 , 99, 802-816
Drašar P., Buděšínský M., Reschel M., Pouzar V., Černý I.: Etienic etienate as synthon for the synthesis of steroid oligoester gelators, Steroids, 2005, 70, 615-625.
Drašar P., Moravcová J.: Recent advances in analysis of Chinese medical plants and traditional medicines, Journal of Chromatography B, 2004, 812, 3–21.
Zelenka K., Trnka T., Tišlerová I., Král V., Dukh M., Drašar P.: Synthesis of porphyrin receptors modified by glycosylated steroids, Coll. Czech. Chem. Commun. 2004, 69, 1169.
Dukh M., Šaman D., Lang K., Pouzar V., Černý I., Drašar P., Král V.: Steroid porphyrin conjugate for saccharide sensing in protic media. Org. Biomol. Chem. 2003, 1, 3458-3463.
Dukh M., Šaman D., Kroulík J., Černý I., Pouzar V., Král V., Drašar P.: Metal Coordination as a Tool for Controlling the Self-Assembling and Gelation Properties of Novel Type Cholic Amide-Phenanthroline Gelating Agent. Tetrahedron 2003, 59, 4069-4076.
Drašar P., Valter B., Paleta O.; Grafické vyjádøení chirality chemických slouèenin Chem. Listy 2003, 97, 1027–1046.
Dukh M., Drašar P., Černý I., Pouzar V., Shriver J. A., Král V., Sessler J. L.: Novel Deep Cavity Calix[4]pyrroles Derived from Steroidal Ketones. Supramolecular Chemistry, 2002, 14, 237-244.
Reschel M., Buděšínský M., Černý I., Pouzar V., Drašar P.: Synthesis of Linear Steroid Oligoesters Based on Etienic Acid. Collect. Czech. Chem. Commun. 2002, 67, 1709-1718.
Dukh M., Černý I., Urbanský M., Pouzar V., Král V., Drašar P.: Polycyklické makrocykly obsahující pyrrol s pøímo vázanými steroidními substituenty v mesopolohách, Czech Pat. 2002, 290491, Appl. 1999, 3098-99.
Kamano Y, Nogawa T, Yamashita A, Hayashi M, Inoue M, Drašar P, and Pettit GR; Isolation and Structure of a 20,21-Epoxybufenolide Series from "Ch'an Su", J. Nat. Prod. 2002, 65, 1001.
Černý I, Budešínský M, Pouzar V, Drašar P: Linear chaining of etienic acid derivatives with the amide bond. Synthesis of oligomeric steroids, Coll. Czech. Chem. Commun. 2001, 66, 933.
Pacák, J. and Drašar, P.; Výuka sacharidù a její didaktická úsilí (Didactical problems of Teaching of Saccharides). Chemicke listy 2001, 95(10), 665-669.
Urbanský M, Proška J, Drašar P.: Fused thiazoloandrostanes and their quaternary salts, synthesis and cooperative ligand binding to muscarinic acetylcholine receptor, Coll. Czech. Chem. Commun. 1999, 64, 1457.
Kamano Y, Kotake A, Nogawa T, Hashima H, Tozawa M, Morita H, Takeya K, Itokawa H, Matsuo I, Ichihara Y, Drasar P, Pettit GR: Conformational preference of two toad poison bufadienolides, cinobufagin and bufotalin, Coll. Czech. Chem. Commun. 1998, 63, 1663.

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