Doctoral studies
Ing. Anna Marešová
Masters's degree
bc. Lukáš Mazur
bc. František Fiala
bc. Jan Mazel
Bachelor's degree
Gabriela Merhoutová
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Copyright: UCT Prague 2015
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[seo_desc] => Studies Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology UCT Prague University of Chemistry and Technology Prague
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[obsah] => We offer an undergraduate bachelor degree program as well as a master degree program in the Czech language only. For information about study programs in English, please visit the university's website.
Study with us
We offer the research degree program Doctor of Philosophy (PhD) in Organic Chemistry.
Why study for a PhD at our department?
You will become a member of an internationally recognised research team providing high quality research. You will develop the skills and the knowledge needed to pursue your chosen career—in academia, at research organizations, or in public service.
How to apply?
Our prospective student portal provides details about the application process for PhD programmes at UCT Prague.
Our past graduates
Battaglia Caren Bc. (Master Double Degree)
Abdulmanea Khaled Saleh Omar, MSc., PhD (Yemen): Flavonoids in the Apiaceae family (2012)
Irekhjargal Jambal, MSc., PhD (Mongolia): Inhibitors of galactosyltransferases (2012)
Our present students
Uladzimir Bildziukevich, MSc. (Belarus): Steroid-based compounds with potential pharmacologic importance
Jana Šusteková, Ing. (Slovakia): Self-assembly in supramolecular systems based on steroid compounds
Joint-degree doctoral programme graduates
Ing. Ondřej Jurček, PhD (Czechia): Steroid conjugates for applications in pharmacology and biology (2011), with the Faculty of Mathematics and Science, University of Jyväskylä, Finland
Ing. Helena Heissigerová, PhD (Czechia): Glycosyltransferases: Etude comparative, modelisation moleculaire et synthese de nouveaux inhibiteurs (2003), with the Université Joseph Fourier – Grenoble, France
9 We accept students within the framework of the IAESTE exchange programme.
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[obsah] => We are open to cooperation on common projects or through contracts.
We offer our partners:
- synthesis of specialty chemicals from natural compounds and their analogs
- steroids and other terpeniods
- porphyrins
- flavonoids
- saccharides
- glycosides, C-glycosides
- non-isotopic labeled compounds
- prepararion of antibodies, immunogens, tracers and others components of immunoassays
- structural analysis
- quantitative analysis
- consultancy in the development of synhtetic methods
- consultancy in the development of analytical methods
- specialty chemicals and immunochemicals from our libraries
Scientific orientation of the department
- The search for new compounds with novel properties.
- Biologically active compounds are our inspiration.
Research topics
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Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, UCT Prague |
k (+420) 220 444 260 |
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Technická 5 |
W (+420) 220 444 422 |
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166 28 Praha 6 |
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Head of Department |
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Prof. Dr. RNDr. Oldřich Lapčík |
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k (+420) 220 444 448 |
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b Oldrich.Lapcik@vscht.cz |
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room BS18 |
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Secretary of Department |
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Secretary |
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assoc. prof. Ing. Kamil Parkan, Ph.D. |
Irena Dražilová |
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k (+420) 220 444 265 |
k (+420) 220 444 260 |
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b Kamil.Parkan@vscht.cz |
b Irena.Drazilova@vscht.cz |
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website |
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CV |
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| building A, room A246 |
building A, room A244 |
The Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology at UCT Prague was founded in 1991 as the successor to the Laboratory of Monosaccharides. Its mission includes both education and training at the graduate as well as postgraduate level and research and development in several fields crossing the frontier between organic chemistry and biology.
Our department's research aims to understand living systems at the molecular level, providing new molecules with new properties that eventually could become medicines, among other things. It is essential to continue this research at the fundamental level so as to provide tools for designing, synthesizing, and evaluating new functional molecules for targeting applications. Nature is our inspiration.
Key research areas include:
- Chemistry of steroids and other terpenoids
- Chemistry of supramolecules with chiral natural compounds
- Synthesis of ligands for the cell-cell recognition
- The development of nanosensors for the sensing of pathogenic processes
- Analytical and bioanalytical methods
- Forensic analysis of biologically active compounds
- Chemistry of saccharides and glycomimetics
- Molecular modeling
The study of the chemical background of natural processes is a huge adventure, which we ourselves enjoy and wish to share with others. —Oldrich Lapcik, Department Chair
For further details about our research topics, please visit the webpages of individual teams.
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- The search for new compounds with novel properties.
- Biologically active compounds are our inspiration.
Research topics
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The group is currently addressing, in particular, application, medical and chemical-biological issues of selected natural substances. We deal with the isolation of natural products from natural materials and the preparation of analogues of medically popent substances. The products of our work are intended for testing a specific biological activity or application potential in (bio)analytical methods.
Our main portfolio includes chemistry of: steroid compounds (estradiol, androgens, cardiotonics), mitotic inhibitors (colchicine, taxol), SERCA inhibitors (trilobolide and thapsigargin) and antimalarials (artemisinin), maturation inhibitors HIV-1 (bevirimat).
The group also focuses on the synthesis of fluorophores and fluorescently labeled natural substances. Our favorite fluorophores include BODIPY, but we also work with cyanine and xanthene dyes. This category also includes the conjugation of natural substances with photosensitizers based again on BODIPY, natural chlorins, bacteriochlorins and porphyrins. These products are useful tools for studying the fate of natural substances in living cells using fluorescence microscopy or as potential drugs in photodynamic therapy.
In general, we like to synthesize labeled molecules. These derivatives of natural substances may be important as tools useful in proteomics (biotinylated derivatives, PROTACs). This cathegory includes the preparation of haptens for immunochemical methods.
The link to the publications representing the results of our work is located in the box on the right.
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MASTER THESES
Anna Marešová (consultant Ing. Tomáš Zimmermann, Ph.D.), Synthesis of P2X7 antagonists and their radiolabeling; opponent doc. Ing. Alexander Popkov, Ph.D.; defended 3.6.2021.
Pavel Trousil (conzultant Ing. Tomáš Zimmermann, Ph.D.), Synthesis and characterization of 17α-homodimers of estradiol; opponent RNDr. Jarmila Králová, Ph.D.; defended 3.6.2021.
BACHELOR THESES
Vanda Lupjanová (conzultant Ing. Jan Hajdůch, Ph.D.), Preparation and use of nitrodipyrromethanes for the synthesis of fluorophores with a modifiable amino group; defended 22.6.2021.
Kateřina Váchalová Fluorescent probes for lipoid compounds imaging on live cells; defended 29. 6. 2020.
František Fiala Conjugates of BODIPY with taxol for live-cell imaging and photodynamic therapy in tumor models; defended 29. 6. 2020.
Jan Mazel Maturation inhibitors derived from bevirimat; defended 24. 8. 2020.
Pavel Trousil Synthesis and study of mitotic inhibitors; defended 17. 6. 2019.
CONSULTANT
MASTER THESES
Barbora Baubínová (supervisor prof. Dr. RNDr. Oldřich Lapčík), Fluoroimmunoassay of anabolic steroids; defended 10. 6. 2020.
Jiří Vyšohlíd (supervisor prof. RNDr. Pavel B. Drašar, DSc.), Study of biologically active sesquiterpene lactones of guaianolide type isolated from L. trilobum; defended 6. 6. 2019.
Jiří Bejček (supervisor Ing. Silvie Rimpelová, Ph.D.), Biological activity of novel fluorescently labelled ligands of Na+/K+ ATPase; defended 6. 6. 2018.
Nikita Dovzhenko (supervisor doc. Mgr. Taťjana Šiškanová, CSc.), Modified electrodes for electrochemical detection of psychoactive substances; defended 4. 6. 2018.
David Kodr (supervisor prof. RNDr. Pavel B. Drašar, DSc.), Synthesis of fluorescent labelled betulinic acid derivatives; defended 6. 6. 2018.
Radka Kucherková (supervisor prof. RNDr. Pavel B. Drašar, DSc.), Synthesis and study of analogues of BODIPY dyes; defended 7. 6. 2018.
Tomáš Zimmermann (supervisor prof. RNDr. Pavel B. Drašar, DSc.), Synthesis of new trilobolide derivatives; defended 3. 6. 2015.
Pavla Tomanová (supervisor prof. RNDr. Pavel B. Drašar, DSc.), Synthesis and study of porphyrin-trilobolide conjugates for molecular biology; defended 4. 6. 2014.
BACHELOR THESES
Jiří Vyšohlíd (supervisor prof. RNDr. Pavel B. Drašar, DSc.), Study of sesquiterpene derivatives; defended 27. 6. 2017.
Kryštof Škach (supervisor prof. Ing. Tomáš Ruml, CSc.), Synthesis and study of bombesin analogue with photosenzitizers; defended 23. 6. 2016.
Markéta Šimková (supervisor prof. RNDr. Pavel Drašar, DSc.), Study of components of Laserpitium prutenicum L.; defended 23. 6. 2016.
Radka Kucherková (supervisor prof. RNDr. Pavel B. Drašar, DSc.), Synthesis of fluorescent methoxy derivatives of BODIPY dyes; defended 27. 6. 2016.
David Kodr (supervisor prof. RNDr. Pavel B. Drašar, DSc.), Synthesis of cyproterone photosensitizers conjugates; defended 23. 6. 2016.
Tereza Šimková (supervisor prof. RNDr. Pavel B. Drašar, DSc.), Preparation and study of estradiol derivatives with fluorescent label; defended 25. 6. 2015.
Lucie Poláková (Odstrčilová) (supervisor prof. RNDr. Pavel B. Drašar, DSc.), Preparation of components of immunochemical kits for the detection of bioactive steroids; defended 28. 8. 2015.
Tomáš Zimmermann (supervisor prof. RNDr. Pavel B. Drašar, DSc.), Synthesis and study of tribolide derivatives; defended 26. 6. 2013.
Ludmila Škorpilová (supervisor prof. Ing. Zdeněk Wimmer, DrSc.), Derivatives of cholesterol for visualization of apoptosis; defended 26. 6. 2013.
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We focus on the detailed study of the 3D arrangements of small and larger biomolecules, like mono- and oligosaccharides, steroids and other compounds—either experimentally, using various spectral methods; or theoretically, using appropriate computational procedures and molecular modeling.
A further step involves calculation or prediction of the various physico-chemical, chemical, as well as pharmacological or biological properties of these molecules, including those that have not been synthetized yet. These problems encompass several disciplines such as:
- stereochemistry and conformational analysis
- spectral (NMR, IR, UV, MS) and chiroptical properties (CD, VCD, ROA)
- chemical kinetics and reaction mechanisms
- structural biochemistry and biology
- biochemistry and pharmacology
- forensic analysis
Some recent research topics as examples:
Stereochemistry and conformational analysis
- Dynamics of conformational changes of simple furanose saccharides which serve as a model of the principal carbohydrate component of DNA and RNA
- Conformational analysis of pseudo disaccharides (C-disaccharides) as potential glycosidase inhibitors
Spectral and chiroptical properties
- Calculations of the NMR and IR spectra of smaller bioorganic molecules; the effect of solvation
- Optical rotation, optical rotational dispersion and vibrational circular dichroism as sensitive indicators of equilibrium solution conformations of various bioorganic molecules
Chemical kinetics and reaction mechanisms
- Selectivity of nucleophilic cleavage of the three-membered oxirane ring
- Selectivity, mechanism and catalysts for acetylation of saccharides
Biochemistry and pharmacology
- Interaction of enzymes with carbohydrate as well as other substrates
- Predictions of lipophilicity, solubility and other pharmacological properties of compounds
Forensic analysis
- Prediction of spectral properties of novel synthetic drugs of abuse and study of their interactions with receptors
Research Summary
Our group interests lie in the field of organic chemistry, focusing especially on stereoslective synthesis, total synthesis of natural or non-natural glycomimetics. The aim of our research is to design and developer new synthetic tools, allowing ultimately for the efficient and rapid synthesis of C-glycosides and C-disaccharides.
Main Specific Research Interests
Syntesis of C-glykosides
1. Parkan, K.; Pohl, R.; Kotora, M. Chem. Eur. J. 2014, 20, 4414 – 4419. Online
2. Šnajdr, I.; Parkan, K.; Hessler, F.; Kotora M. Beilstein J. Org. Chem. 2015, 11, 1392–1397. Odkaz
Modular Stereoselective Synthesis of C-disaccharides and C-oligosaccharides.
1. Oroszová, B.; Choutka, J.; Pohl, R.; Parkan, K. Chem. Eur. J. 2015, 21, 7043-7047. Online
2. Lovyova, Z.; Parkan, K.; Kniezo, L. Tetrahedron 2011, 67, 4967 – 4979. Online
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