stdClass Object
(
[nazev] => Department of Chemistry of Natural Compounds
[adresa_url] =>
[api_hash] =>
[seo_desc] =>
[jazyk] =>
[jednojazycny] =>
[barva] =>
[indexace] => 1
[obrazek] =>
[ga_force] =>
[cookie_force] =>
[secureredirect] =>
[google_verification] =>
[ga_account] =>
[ga_domain] =>
[ga4_account] => G-VKDBFLKL51
[gtm_id] =>
[gt_code] =>
[kontrola_pred] =>
[omezeni] => 0
[pozadi1] =>
[pozadi2] =>
[pozadi3] =>
[pozadi4] =>
[pozadi5] =>
[robots] =>
[htmlheaders] =>
[newurl_domain] => 'uchpl.vscht.cz'
[newurl_jazyk] => 'en'
[newurl_akce] => '[en]'
[newurl_iduzel] =>
[newurl_path] => 8548/4164/1791
[newurl_path_link] => Odkaz na newurlCMS
[iduzel] => 1791
[platne_od] => 31.10.2023 17:12:00
[zmeneno_cas] => 31.10.2023 17:12:07.751856
[zmeneno_uzivatel_jmeno] => Jan Kříž
[canonical_url] =>
[idvazba] => 4642
[cms_time] => 1714072323
[skupina_www] => Array
(
)
[slovnik] => stdClass Object
(
[logo_href] => /
[logo] => 
[social_fb_odkaz] =>
[social_tw_odkaz] =>
[social_yt_odkaz] =>
[paticka_budova_a_nadpis] => BUILDING A
[paticka_budova_a_popis] => Rector,
Department of Communications,
Department of Education,
FCT Dean’s Office,
Centre for Information Services
[paticka_budova_b_nadpis] => BUILDING B
[paticka_budova_b_popis] => Department of R&D, Dean’s Offices:
FET,
FFBT,
FCE,
Computer Centre,
Department of International Relations,
Bursar
[paticka_budova_c_nadpis] => BUILDING C
[paticka_budova_c_popis] => Crèche Zkumavka,
General Practitioner,
Department of Economics and Management,
Department of Mathematics
[paticka_budova_1_nadpis] => NATIONAL LIBRARY OF TECHNOLOGY
[paticka_budova_1_popis] =>
[paticka_budova_2_nadpis] => CAFÉ CARBON
[paticka_budova_2_popis] =>
[paticka_adresa] => UCT Prague
Technická 5
166 28 Prague 6 – Dejvice
IČO: 60461337
VAT: CZ60461373
Data mail: sp4j9ch
Copyright: UCT Prague 2015
Information provided by the Department of International Relations and the Department of R&D. Technical support by the Computing Centre.
[paticka_odkaz_mail] => mailto:Ondrej.Simak@vscht.cz
[social_fb_title] =>
[social_tw_title] =>
[social_yt_title] =>
[google_search] => 001523547858480163194:u-cbn29rzve
[drobecky] => You are here: UCT Prague - FFBT - UCHPL
[aktualizovano] => Updated
[autor] => Author
[paticka_mapa_alt] =>
[stahnout] => Download
[intranet_odkaz] => http://intranet.vscht.cz/
[intranet_text] => Intranet
[logo_mobile_href] => /
[logo_mobile] =>
[mobile_over_nadpis_menu] => Menu
[mobile_over_nadpis_search] => Search
[mobile_over_nadpis_jazyky] => Languages
[mobile_over_nadpis_login] => Login
[menu_home] => Homepage
[zobraz_desktop_verzi] => switch to desktop version
[zobraz_mobilni_verzi] => switch to mobile version
[paticka_mapa_odkaz] =>
[nepodporovany_prohlizec] => For full access, please use different browser.
[preloader] => Wait a second...
[social_in_odkaz] =>
[social_li_odkaz] =>
[more_info] =>
)
[poduzel] => stdClass Object
(
[6151] => stdClass Object
(
[obsah] =>
[poduzel] => stdClass Object
(
[6154] => stdClass Object
(
[obsah] =>
[iduzel] => 6154
[canonical_url] => //uchpl.vscht.cz
[skupina_www] => Array
(
)
[url] =>
[sablona] => stdClass Object
(
[class] =>
[html] =>
[css] =>
[js] =>
[autonomni] =>
)
)
[6152] => stdClass Object
(
[obsah] =>
[iduzel] => 6152
[canonical_url] => //uchpl.vscht.cz
[skupina_www] => Array
(
)
[url] =>
[sablona] => stdClass Object
(
[class] =>
[html] =>
[css] =>
[js] =>
[autonomni] =>
)
)
[6153] => stdClass Object
(
[obsah] =>
[iduzel] => 6153
[canonical_url] => //uchpl.vscht.cz
[skupina_www] => Array
(
)
[url] =>
[sablona] => stdClass Object
(
[class] =>
[html] =>
[css] =>
[js] =>
[autonomni] =>
)
)
)
[iduzel] => 6151
[canonical_url] =>
[skupina_www] => Array
(
)
[url] =>
[sablona] => stdClass Object
(
[class] =>
[html] =>
[css] =>
[js] =>
[autonomni] =>
)
)
[6180] => stdClass Object
(
[obsah] =>
[poduzel] => stdClass Object
(
[12485] => stdClass Object
(
[nazev] => Studies
[seo_title] => Studies
[seo_desc] => Studies Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology UCT Prague University of Chemistry and Technology Prague
[autor] =>
[autor_email] =>
[obsah] => We offer an undergraduate bachelor degree program as well as a master degree program in the Czech language only. For information about study programs in English, please visit the university's website.
Study with us
We offer the research degree program Doctor of Philosophy (PhD) in Organic Chemistry.
Why study for a PhD at our department?
You will become a member of an internationally recognised research team providing high quality research. You will develop the skills and the knowledge needed to pursue your chosen career—in academia, at research organizations, or in public service.
How to apply?
Our prospective student portal provides details about the application process for PhD programmes at UCT Prague.
Our past graduates
Battaglia Caren Bc. (Master Double Degree)
Abdulmanea Khaled Saleh Omar, MSc., PhD (Yemen): Flavonoids in the Apiaceae family (2012)
Irekhjargal Jambal, MSc., PhD (Mongolia): Inhibitors of galactosyltransferases (2012)
Our present students
Uladzimir Bildziukevich, MSc. (Belarus): Steroid-based compounds with potential pharmacologic importance
Jana Šusteková, Ing. (Slovakia): Self-assembly in supramolecular systems based on steroid compounds
Joint-degree doctoral programme graduates
Ing. Ondřej Jurček, PhD (Czechia): Steroid conjugates for applications in pharmacology and biology (2011), with the Faculty of Mathematics and Science, University of Jyväskylä, Finland
Ing. Helena Heissigerová, PhD (Czechia): Glycosyltransferases: Etude comparative, modelisation moleculaire et synthese de nouveaux inhibiteurs (2003), with the Université Joseph Fourier – Grenoble, France
9 We accept students within the framework of the IAESTE exchange programme.
[urlnadstranka] =>
[ogobrazek] =>
[pozadi] =>
[iduzel] => 12485
[canonical_url] =>
[skupina_www] => Array
(
)
[url] => /studies
[sablona] => stdClass Object
(
[class] => stranka_submenu
[html] =>
[css] =>
[js] =>
[autonomni] => 1
)
)
[12486] => stdClass Object
(
[nazev] => Cooperation
[seo_title] => Cooperation
[seo_desc] => Cooperation Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology UCT Prague University of Chemistry and Technology Prague
[autor] =>
[autor_email] =>
[obsah] => We are open to cooperation on common projects or through contracts.
We offer our partners:
- synthesis of specialty chemicals from natural compounds and their analogs
- steroids and other terpeniods
- porphyrins
- flavonoids
- saccharides
- glycosides, C-glycosides
- non-isotopic labeled compounds
- prepararion of antibodies, immunogens, tracers and others components of immunoassays
- structural analysis
- quantitative analysis
- consultancy in the development of synhtetic methods
- consultancy in the development of analytical methods
- specialty chemicals and immunochemicals from our libraries
Scientific orientation of the department
- The search for new compounds with novel properties.
- Biologically active compounds are our inspiration.
Research topics
|
Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, UCT Prague |
k (+420) 220 444 260 |
|
Technická 5 |
W (+420) 220 444 422 |
|
166 28 Praha 6 |
|
|
|
 |
Head of Department |
|
|
Prof. Dr. RNDr. Oldřich Lapčík |
|||
|
k (+420) 220 444 448 |
|||
|
b Oldrich.Lapcik@vscht.cz |
|||
|
room BS18 |
|
|
Secretary of Department |
|
Secretary |
|
assoc. prof. Ing. Kamil Parkan, Ph.D. |
Irena Dražilová |
||
|
k (+420) 220 444 265 |
k (+420) 220 444 260 |
||
|
b Kamil.Parkan@vscht.cz |
b Irena.Drazilova@vscht.cz |
||
website |
|
||
CV |
|||
| building A, room A246 |
building A, room A244 |
The Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology at UCT Prague was founded in 1991 as the successor to the Laboratory of Monosaccharides. Its mission includes both education and training at the graduate as well as postgraduate level and research and development in several fields crossing the frontier between organic chemistry and biology.
Our department's research aims to understand living systems at the molecular level, providing new molecules with new properties that eventually could become medicines, among other things. It is essential to continue this research at the fundamental level so as to provide tools for designing, synthesizing, and evaluating new functional molecules for targeting applications. Nature is our inspiration.
Key research areas include:
- Chemistry of steroids and other terpenoids
- Chemistry of supramolecules with chiral natural compounds
- Synthesis of ligands for the cell-cell recognition
- The development of nanosensors for the sensing of pathogenic processes
- Analytical and bioanalytical methods
- Forensic analysis of biologically active compounds
- Chemistry of saccharides and glycomimetics
- Molecular modeling
The study of the chemical background of natural processes is a huge adventure, which we ourselves enjoy and wish to share with others. —Oldrich Lapcik, Department Chair
For further details about our research topics, please visit the webpages of individual teams.
[urlnadstranka] => [ogobrazek] => [pozadi] => [iduzel] => 6181 [canonical_url] => [skupina_www] => Array ( ) [url] => /home [sablona] => stdClass Object ( [class] => stranka [html] => [css] => [js] => [autonomni] => 1 ) ) [24134] => stdClass Object ( [obsah] => [iduzel] => 24134 [canonical_url] => [skupina_www] => Array ( ) [url] => [sablona] => stdClass Object ( [class] => [html] => [css] => [js] => [autonomni] => ) ) ) [iduzel] => 6180 [canonical_url] => [skupina_www] => Array ( ) [url] => [sablona] => stdClass Object ( [class] => [html] => [css] => [js] => [autonomni] => ) ) ) [sablona] => stdClass Object ( [class] => web [html] => [css] => [js] => [autonomni] => 1 ) [api_suffix] => )DATA
stdClass Object
(
[nazev] => Staff
[seo_title] => Staff
[seo_desc] => Staff Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology UCT Prague University of Chemistry and Technology Prague
[autor] =>
[autor_email] =>
[perex] =>
[ikona] =>
[obrazek] =>
[ogobrazek] =>
[pozadi] =>
[obsah] => Professors
|
|
|
|
|
|
Prof. RNDr. Dr. Oldřich Lapčík |
Prof. RNDr. Pavel Drašar, DSc. |
||
|
k (+420) 220 444 448 |
k (+420) 220 443 698 |
||
|
b Oldrich.Lapcik@vscht.cz |
b Pavel.Drasar@vscht.cz |
||
| website | |||
|
room BS18 |
room K09 |
||
|
|
|
|
|
|
|
|
|
|
|
Prof. Ing. Zdeněk Wimmer, DrSc. |
|
||
|
k (+420) 220 444 398 |
|
||
|
b Wimmerz@vscht.cz |
|
||
|
room K13 |
Associate professors
|
|
|
|
|
|
Doc. RNDr. Jan Staněk, CSc. |
Doc. Dr. Ing. Ivan Raich |
||
|
k (+420) 220 443 681 |
k (+420) 220 443 240 |
||
|
b Jan.Stanek@vscht.cz |
b Ivan.Raich@vscht.cz |
||
|
|
|||
|
|
|||
|
room A248 |
room BS16 |
||
|
|
|
|
|
|
|
doc. Ing. Martin Kuchař, Ph.D. |
|
doc. Ing. Kamil Parkan, Ph.D. |
|
k (+420) 220 444 431 |
k (+420) 220 444 265 |
||
|
b Martin.Kuchar@vscht.cz |
b Kamil.Parkan@vscht.cz |
||
website |
|||
CV |
CV |
||
|
|
room B219 | building A, room A246 |
Assistant professors
|
|
|
|
|
|
|
PharmDr. Petra Cihlářová, Ph.D. |
|
Ing. Elena Prokudina, Ph.D. |
|
k (+420) 220 444 430 |
k (+420) 220 444 448 |
||
| b Petra.Cihlarova@vscht.cz | b Elena.Prokudina@vscht.cz | ||
| website | website | ||
| CV |
CV |
||
|
room B129 |
room BS18 |
||
|
|
|
|
|
|
|
Ing. Ondřej Šimák, Ph.D. |
 |
Ing. Michal Jurášek, Ph.D. |
|
k (+420) 220 183 244 |
k (+420) 220 443 698 |
||
|
b Ondrej.Simak@vscht.cz |
b Michal.Jurasek@vscht.cz |
||
|
|
IOCB |
místnost K09 | |
|
|
|
|
Scientific researcher
|
|
|
|
|
|
Ing. Petr Štěpánek, Ph.D., MBA |
Ing. Roman Effenberg, Ph.D. |
||
|
k (+420) 220 443 797 |
k (+420) 220 444 283 |
||
| b Petr.Stepanek@vscht.cz | b Roman.Effenberg@vscht.cz | ||
| website | website | ||
| CV |
CV |
||
|
room K12 |
místnost A252 |
||
|
|
|
|
Technical employee
|
|
|
|
|
|
Ing. Martina Hlaváčková |
Martina Wimmerová |
||
|
k (+420) 220 444 283 |
k (+420) 220 444 239 |
||
|
room A252 |
room A246 |
Ivan Raich, PhD, assoc. prof. |
||
Education: |
||
|
1982-1986 |
M.S. studies: University of Chemistry and Technology, Prague, Faculty of Food and Biochemical Technology |
|
|
M.S. thesis: Partial acetylation and deacetylation of methyl α- and β‑D‑threofuranoside and methyl α- and β‑D‑erythrofuranoside |
||
|
Supervisor: prof. Jiří Jarý |
||
|
1986-1994 |
PhD studies: UCT Prague, FFBT |
|
|
PhD: Methyl erythrosides with aziridine, oxirane and thiirane ring |
||
|
Supervisor: prof. Jiří Jarý, assoc. prof. Jan Staněk |
||
|
2012 |
Associate professor in Organic chemistry, UCT Prague, FFBT |
|
Practice: |
||
|
1986-1988 |
PhD studies, UCT Prague, FFBT, Laboratory of monosaccharides |
|
|
1988-1989 |
military service |
|
|
1989-1993 |
PhD studies, UCT Prague, FFBT, Laboratory of monosaccharides, Department of Chemistry of Natural Compounds |
|
|
1993-present |
UCT Prague, Department of Chemistry of Natural Compounds |
|
|
1993-1995 |
senior researcher |
|
|
1995-2012 |
assistant professor |
|
|
2012-present |
associate professor |
|
Teaching: |
||
|
|
Computer technology |
|
|
|
Applied computer technology |
|
|
|
Chemical informatics |
|
|
|
Bioinformatics |
|
|
|
Analytical and forensic databases |
|
|
|
Molecular modeling |
|
|
|
Laboratory practice in isolation and separation methods |
|
Scientific interests: |
||
|
|
Stereochemistry and conformational analysis of mono- and disaccharides and other natural compounds |
|
|
|
Molecular modeling and dynamics of bioorganic molecules |
|
|
|
QM calculations of spectra and chiroptical properties |
|
|
|
Solvation of biomolecules |
|
|
|
Theoretical and experimental study of reaction mechanisms |
|
|
Makrlík E., Böhm S., Vaňura P., Raich I.: Extraction and DFT study on interaction of the cesium cation with enniatin B, J. Mol. Struct. 2014, 1076, 564-567. Online |
|
Makrlík E., Böhm S., Vaňura P., Raich I.: Extraction and DFT study on the complexation of the strontium cation with enniatin B, Chem. Phys. 2014, 439(0), 95-99. Online |
|
Brychtová K., Dvořáková L., Opatřilová R., Raich I., Káčerová S., Plaček L., Kalinowski D. S., Richardson D. R., Jampílek J.: Investigation of substituted 6-aminohexanoates as skin penetration enhancers, Bioorg. Med. Chem. 2012, 20(1), 86-95. Online |
|
Mandelová Z., Opatřilová R., Raich I., Havlíček J., Káčerová S., Pekárek T., Tkadlecová M., Stašková P., Dohnal J., Csollei J., Jampílek J.: Synthesis, physico-chemical properties and DFT calculations of new 2-(4-arylpiperazine-1-yl)-1-(3-ethylbenzofuran-2-yl)ethanols as potential antihypertensive agents, Current Organic Chemistry 2011, 15(7), 1081-1096. Online |
|
Kaminský J., Raich I., Tomčáková K., Bouř P.: Conformational behavior of simple furanosides studied by optical rotation, J. Comput. Chem. 2010, 31(11), 2213-2224. Online |
|
Brychtová K., Opatřilová R., Raich I., Kalinowski D. S., Dvořáková H., Plaček L., Csollei J., Richardson D. R., Jampílek J.: Investigating the activity of 2-substituted alkyl-6-(2,5-dioxopyrrolidin-1-yl)hexanoates as skin penetration enhancers, Bioorg. Med. Chem. 2010, 18(24), 8556-8565. Online |
|
Brychtová K., Jampílek J., Opatřilová R., Raich I., Farsa O., Csollei J.: Synthesis, physico-chemical properties and penetration activity of alkyl-6-(2,5-dioxopyrrolidin-1-yl)-2-(2-oxopyrrolidin-1-yl)hexanoates as potential transdermal penetration enhancers, Bioorg. Med. Chem. 2010, 18(1), 73-79. Online |
|
Opatřilová R., Jampílek J., Raich I., Káčerová S., Havlíček J., Pekárek T., Dohnal J., Csollei J.: Synthesis, characterization and physicochemical properties of new 2-(4-arylpiperazin-1-yl)-1-(3-methylbenzofuran-2-yl)ethanols as potential antihypertensive agents, Current Organic Chemistry 2009, 13(10), 965-975. Online |
|
Brychtová K., Slabá B., Plaček L., Jampílek J., Raich I., Csollei J.: Coupling reactions of α-bromocarboxylate with non-aromatic N-heterocycles, Molecules 2009, 14(8), 3019-3029. Online |
|
Kaminský J., Raich I.: Stereochemical preference of nucleophilic cleavage in methyl erythrofuranosides explained by density functional theory computations, J. Mol. Struct.: THEOCHEM 2008, 860(1-3), 32-39. Online |
|
Jampílek J., Řečková Z., Imramovský A., Raich I., Vinšová J., Dohnal J.: Study of stability of new mutual prodrugs with antimycobacterial activity, Current Organic Chemistry 2008, 12(8), 667-674. Online |
|
Vích O., Kniežo L., Dvořáková H., Raich I., Valenta Š.: Conformational preferences of ethyl 2,3-dideoxy-3-[(α-D-glucopyranosyl)methyl]-β-L- and -D-arabino-hexopyranosides, Collect. Czech. Chem. Commun. 2005, 70(12), 2086-2100. Online |
|
Jampílek J., Doležal M., Kuneš J., Šatínský D., Raich I.: Novel regioselective preparation of 5-chloropyrazine-2-carbonitrile from pyrazine-2-carboxamide and coupling study of substituted phenylsulfanylpyrazine-2-carboxylic acid derivatives, Current Organic Chemistry 2005, 9(1), 49-60. Online |
|
Jampílek J., Doležal M., Kuneš J., Raich I., Liška F.: 4-substituted aryl bromides coupling with 4-methoxybenzene-1-thiol by means of copper catalysts, Chemical Papers 2005, 59(3), 182-186. |
|
Synytsya A., Urbanová M., Setnička V., Tkadlecová M., Havlíček J., Raich I., Matějka P., Synytsya A., Čopíková J., Volka K.: The complexation of metal cations by D-galacturonic acid: a spectroscopic study, Carbohydr. Res. 2004, 339(14), 2391-2405. Online |
|
Jampílek J., Doležal M., Kuneš J., Víchová P., Raich I., Jun D., O'Connor R., Clynes M.: Preparation of 2-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)propionic acid (VUFB 20615) and 2-methyl-2-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)propionic acid (VUFB 20623) as potential antileukotrienic agents, Current Organic Chemistry 2004, 8(13), 1235-1243. Online |
|
Bouř P., Raich I., Kaminský J., Hrabal R., Čejka J., Sychrovský V.: Restricted Conformational Flexibility of Furanose Derivatives: Ab Initio Interpretation of Their Nuclear Spin-Spin Coupling Constants, J. Phys. Chem. A 2004, 108(30), 6365-6372. Online |
|
Raich I.: The use of molecular modeling in industry, CHEMagazin 1997, 7(5), 28-29. |
|
Moravcová J., Čapková J., Staněk J., Raich I.: Methyl 5-deoxy-α and β-D-xylofuranosides, J. Carbohydr. Chem. 1997, 16(7), 1061-1073. Online |
|
Jarý J., Raich I.: Synthesis of methyl 2,3-anhydro-α- and -β-L-erythrofuranoside, Carbohydr. Res. 1993, 242, 291-295. Online |
|
Marek M., Raich I., Kefurt K., Jarý J., Rouwenhorst I. M.: Enzymic deacetylation of methyl 2,3-di-O-acetyl-α- and β-D-threofuranoside, Biocatalysis 1992, 6(2), 135-143. Online |
|
Jarý J., Marek M., Raich I.: Partial methylation of methyl α-D- and β-D-threofuranoside, Collect. Czech. Chem. Commun. 1990, 55(7), 1777-1782. Online |
[iduzel] => 14467 [canonical_url] => //uchpl.vscht.cz/contact/staff/IvanRaich/publications [skupina_www] => Array ( ) [url] => /contact/staff/IvanRaich/publications [sablona] => stdClass Object ( [class] => stranka [html] => [css] => [js] => [autonomni] => 1 ) ) ) [iduzel] => 14464 [canonical_url] => //uchpl.vscht.cz/contact/staff/IvanRaich [skupina_www] => Array ( ) [url] => /contact/staff/IvanRaich [sablona] => stdClass Object ( [class] => stranka [html] => [css] => [js] => [autonomni] => 1 ) ) [56105] => stdClass Object ( [nazev] => Michal Jurášek [seo_title] => Michal Jurášek [seo_desc] => [autor] => [autor_email] => [obsah] =>
Education: |
||
|
1998 - 2012 |
Sportovní gymnázium Dany a Emila Zátopkových, Ostrava |
|
|
|
University of Chemistry and Technology (UCT Prague), Faculty of Food and Biochemical Technology (FPBT) |
|
|
2005 - 2009 |
Bachelor thesis: Amides derived from bile acids (bc.) |
|
|
|
Supervisor: prof. RNDr. Pavel Drašar, DSc. |
|
|
2010 - 2012 |
Master thesis: Steroid derivatives for supramolecular chemistry (Ing.) |
|
|
Supervisor: prof. RNDr. Pavel Drašar, DSc. |
||
|
2012 - 2018 |
Internal PGS at UCT Prague, FPBT |
|
|
Dissertation: Synthons and receptors with chiral attributes (Ph.D.) |
||
|
Supervisor: prof. RNDr. Pavel Drašar, DSc. |
||
Practice: |
||
|
2012 - 2018 |
PGS, UCT Prague, Laboratory of Chemistry of Steroids and Biologically Active Substances |
|
|
2009 - 2018 |
Researcher (V4) at the Dpt. of Chemistry of Natural Compounds, UCT Prague, FPBT |
|
|
2019 - |
Assistant Professor (A2) at the Dpt. of Chemistry of Natural Compounds, UCT Prague, FPBT | |
|
Teaching: |
||
|
|
Chemistry of natural compounds (M342004) - garant |
|
|
|
Selected chapters from the chemistry of natural substances (N342011) - garant |
|
|
|
Structural analysis of natural substances (N342005, D342001) - garant |
|
|
|
Management and consultation of bachelor's, master's and dissertation theses |
|
Professional interest: |
||
|
|
Chemistry and analysis of steroids (hormonally and non-hormonally active) |
|
|
|
Terpene chemistry and analysis (triterpenes, sesquiterpenes) |
|
|
|
Chemistry of fluorescent dyes for biological applications |
|
|
Labeling of substances for medical applications |
||
|
|
Photosensitizers for the treatment of tumors (PDT) |
|
|
|
Isolation of natural substances from plant materials |
|
|
Laboratory methodology for teaching and practice |
||
|
Chemical biology and biochemistry |
||
Professional activities: |
||
|
|
since 2021 editor of the journal Chemické listy | |
| since 2021 member of the ECTN expert group | ||
Membership: |
||
|
Czech Chemical Society (CSCH) |
||
|
Isoprenoid society |
||
Awards: |
||
| 2012 | Unipetrol Award for diploma thesis "Steroid derivatives for supramolecular chemistry". Most-Velebudice, 11.12. 2012 | |
| 2014 | Teva and Phytochemical Society of Europe (PSE Europe) Award at the 22nd International Conference on Isoprenoids 2014, for the lecture "Click chemistry in steroid and terpene chemical biology tools". Prague, Czech Republic, 7.8-10.8. 2014. | |
| 2015 |
Conference Award 67th Congress of Chemists for the poster "Sesquiterpene lactones from Laserpitium archangelica". High Tatras, Slovakia, 7.8.-11.8. 2015. |
|
| 2015 |
Votoček Scholarship of the University of Chemistry and Technology in Prague, 2015. |
|
[urlnadstranka] => [ogobrazek] => [pozadi] => [poduzel] => stdClass Object ( [63358] => stdClass Object ( [nazev] => Grants [seo_title] => Grants [seo_desc] => [autor] => [autor_email] => [obsah] =>
|
Name of Project |
Implementation period
|
Provider
|
Role |
|
Modulation of capsid lattice stability: promising targets for HIV-1 inhibition |
2020 - 2022 |
GAČR |
team member |
|
Center for Recombinant Biotechnology and Immunotherapeutics (CEREBIT) |
2018 - 2022 |
G_12 |
team member |
|
Development of fluorescent probes for determination of cholesterol content, localization and transport in eukaryotic cells |
2017 - 2019 |
GAČR |
team member |
|
Relationship between biological activity and intracellular localization of sesquiterpene lactones |
2014 - 2016 |
GAČR |
team member |
|
Development of rapid immunochemical tests for the detection of anabolically active steroids |
2011 – 2015 |
MV0 |
team member |
Education: |
|
|
1999 – 2004 |
UCT Prague, technology of organic compounds, organic chemistry; Thesis: Synthesis of novel type of banana shape liquid crystals under supervision of Prof. J. Svoboda |
|
2004 – 2008 |
PhD at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic under supervision of Prof. M. Hocek. Synthesis of novel purine bases and nucleosides bearing functionalized ethyl or cyclopropyl groups in position 6 |
|
2008 |
PhD in Organic Chemistry at UCT Prague |
Professional life: |
|
|
2004 – 2008 |
Postgraduate study at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic |
|
2008 – 2009 |
Head of the laboratory, Azacycles, LTD |
|
2009 – hitherto |
Scientific advisor, National Drug HQ |
|
2011 – hitherto |
Researcher, Department of Chemistry of Natural Compounds, UCT Prague |
|
2014 – hitherto |
Head of research group, Forensic Laboratory of biologically active substances, UCT Prague |
|
2015 – hitherto |
Senior researcher, National Institute of Mental health |
|
Teaching: |
|
|
|
N320080 Toxicology and drugs analysis. Supervisor of PhD theses and diploma theses. |
Subject of interest: |
|
|
|
Psychoactive substances – toxicity, pharmacokinetics, analysis Identification of steroids compounds in biological matrixes Development of new psychopharmaceutics Bioconjugates for diagnostic purposes Isolation and analysis of natural compounds Advisory of amendment of narcotics act |
Professional activities |
|
|
|
Member of the Czech Chemical Society Member of Advisory Board of the National Monitoring Centre for Drugs and Drug Addiction Member of Drug Precursor Working Group under the umbrella of the European Commission Editor of the national peer-reviewed journal: Bulletin of National Drug Headquarters Corresponding author of EWS under the umbrella of EMCDDA |
Fellowships |
|
|
2012 |
Forensic Institute in Riga, Latvia Garda College, Templemore, Ireland |
[poduzel] => Array ( ) [iduzel] => 14775 [canonical_url] => //uchpl.vscht.cz/contact/staff/MartinKuchar [skupina_www] => Array ( ) [url] => /contact/staff/MartinKuchar [sablona] => stdClass Object ( [class] => stranka [html] => [css] => [js] => [autonomni] => 1 ) ) [14631] => stdClass Object ( [nazev] => Zdeněk Wimmer [seo_title] => Zdeněk Wimmer [seo_desc] => Zdeněk Wimmer Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology UCT Prague University of Chemistry and Technology Prague [autor] => [autor_email] => [obsah] =>
Education: |
|
|
1970-1975 |
Institute of Chemical Technology, Prague (now: UCT Prague), programme Organic chemistry, supervisor prof. Dr. Ing. Miloslav Ferles, DrSc. |
|
1975-1978 |
PhD studies at the Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, CSc., programme Organic chemistry, supervisor Ing. Miroslav Romaňuk, DrSc. |
|
2001 |
Scientific degree DSc. awarded by Scientific Council of the Czech Academy of Sciences |
|
2005 |
Associate professor, appointment at Masaryk University, Brno |
|
2009 |
Professor, appointment at Masaryk University, Brno |
Professional life: |
|
|
1978-1987 |
Researcher, Section of Natural Compounds, Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences |
|
1987-2006 |
Senior researcher, Section of Natural Compounds, Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences |
|
2007 |
Senior researcher, Isotope laboratory of Institute of Experimental Botany, Czech Academy of Sciences (part-time job) |
|
2011 |
Professor, Department of Chemistry of Natural Compounds, UCT Prague (part-time job) |
Teaching: |
|
|
|
Natural compounds as raw materials |
|
|
Raw materials from renewable resources |
Professional life: |
|
|
|
Synthesis of biologically and pharmacologically active compounds |
|
|
Supramolecular chemistry focused on utilization of materials from renewable resources |
|
|
Biotechnology in the synthesis of chiral compounds |
|
|
Supercritical extraction of plant materials |
Fellowships |
|
|
1982/1983 |
University Milano, Italy |
|
1992 |
University Hamburg, Germany |
|
1994-1996 |
University La Rochelle, France |
|
1996 |
University Châtenay-Malabry (Paris-Sud), France |
[poduzel] => stdClass Object ( [14632] => stdClass Object ( [nazev] => Info [barva_pozadi] => cervena [uslideru] => false [text] => [iduzel] => 14632 [canonical_url] => [skupina_www] => Array ( ) [url] => [sablona] => stdClass Object ( [class] => infobox [html] => [css] => [js] => [autonomni] => 0 ) ) [6863] => stdClass Object ( [nazev] => Zdeněk Wimmer - Publikace [seo_title] => Zdeněk Wimmer - Publikace [seo_desc] => [autor] => [autor_email] => [obsah] =>
- Bildziukevich U., Rárová L., Janovská L., Šaman D., Wimmer Z.: Enhancing effect of cystamine in its amides with betulinic acid as antimicrobial and antitumor agent in vitro. Steroids 2019, 148, 91-98.
- Özdemir Z., Bildziukevich U., Wimmerová M., Macůrková A., Lovecká P., Wimmer Z.: Plant adaptogens: Natural Medicaments for 21st century? ChemistrySelect 2018, 3, 2196-2214.
- Bildziukevich U., Rárová L., Šaman D., Wimmer Z.: Picolyl amides of betulinic acid as antitumor agents causing tumor cell apoptosis. Eur. J. Med. Chem. 2018, 145, 41-50.
- Özdemir Z., Bildziukevich U., Šaman D., Havlíček L., Rárová L., Navrátilová L., Wimmer Z.: Amphiphilic derivatives of (3β,17β)-3-hydroxyandrost-5-ene-17-carboxylic acid. Steroids 2017, 128, 58-67.
- Škorpilová L., Rimpelová S., Jurášek M., Buděšínský M., Lokajová J., Effenberg R., Slepička P., Ruml T., Kmoníčková E., Drašar P.B., Wimmer Z.: BODIPY-based fluorescent liposomes with seskviterpene lactone trilobolide. Beilstein J. Org. Chem. 2017, 13, 1316-1324.
- Bildziukevich U., Kaletová E., Šaman D., Sievänen E., Kolehmainen E.T., Šlouf M., Wimmer Z.: Spectral and microscopic study of self-assembly of novel cationic spermine amides of betulinic acid. Steroids 2017, 117, 90-96.
- Wimmerová M., Siglerová V., Šaman D., Šlouf M., Kaletová E., Wimmer Z.: Improved enzyme-mediated synthesis and supramolecular self-assembly of naturally occurring conjugates of β-sitosterol. Steroids 2017, 117, 38-43.
- Sperduto C., Smolková M., Jurášek M., Malachowska M., Venanzi M., Monti D., Mancini G., Wimmer Z., Drašar P.: Steroidal ribbons from (3α,5β,20S)-3-hydroxy-20-methyl-pregan-21-oic acid. Lett. Org. Chem. 2016, 13, 711-717.
- Malachowska M., Sperduto C., Darmostuk M., Monti D., Venanzi M. Mancini G., D’Acunto C.W., Králová J., Ruml T., Wimmer Z., Drašar P.B.: Porphyrins with directly meso-attached disaccharide moieties: Synthesis, self-assembly and cellular study. J. Porphyrin. Phthalocyanin. 2016, 20, 773-784.
- Bildziukevich U., Vida N., Rárová L., Kolář M., Šaman D., Havlíček L., Drašar P., Wimmer Z.: Polyamine derivatives of betulinic acid and β-sitosterol: A comparative investigation. Steroids 2015, 100, 27-35.
- Forczek S. T., Laturnus F., Doležalová J., Holík J., Wimmer Z.: Emission of climate relevant volatile organochlorines by plants occurring in temperate forests. Plant Soil Environ. 2015, 61, 103-108.
- Lapčík O., Wimmer Z., Opletal L., Moravcová J., Čopíková J., Drašar P.: Natural Taste-Sour Substances. Chem. Listy 2015, 109, 488-491.
- Čopíková J., Wimmer Z., Lapčík O., Cahlíková L., Opletal L., Moravcová J., Drašar P.: Přírodní látky svíravé a trpké chuti. Chem. Listy 2014, 108, 1053-1057.
- Horník Š., Sajfrtová M., Karban J., Sýkora J., Březinová A., Wimmer Z.: LC-NMR technique in the analysis of phytosterols in natural extracts, Anal. Meth. Chem., 2013, Article ID 526818.
- Čopíková J., Moravcová J., Wimmer Z., Opletal L., Lapčík O., Drašar P.: Náhradní sladidla, Listy 2013, 107, 867-874.
- Bildziukevich, Rárová L., Šaman D., Havlíček L., Drašar P., Wimmer Z.: Amides derived from heteroaromatic amines and selected steryl hemiesters, Steroids 2013, 78, 1347-1352.
- Wimmer Z., Opletal L., Čopíková J., Moravcová J., Abdulmanea K. S. O., Lapčík O., Drašar P.: Kovová chuť přírodních látek a jejich derivátů, Listy 2012, 106, 926-930.
- Vida N., Svobodová H., Rárová L., Drašar P., Šaman D., Cvačka J., Wimmer Z.: Polyamine conjugates of stigmasterol, Steroids 2012, 77, 1212-1218.
- Svobodová H., Nonappa, Lahtinen M., Wimmer Z., Kolehmainen E.: A steroid-based gelator of A(LS)2 type: tuning gel properties by metal coordination, Soft Matter 2012, 8, 7840-7847.
- Jurček O., Lahtinen M., Wimmer Z., Drašar P., Kolehmainen E.: Crystallization, spectral, crystallographical, and thermoanalytical studies of succinobucol polymorphism, Pharm. Sci. 2012, 101, 1794-1802.
- Ikonen S., Jurček O., Wimmer Z., Drašar P., Kolehmainen E.: Antioxidative succinobucol-sterol conjugates: Crystal structures and pseudosymmetry in the crystals, Mol. Struct. 2012, 1011, 25-33.
- Zelenka K., Trnka T., Tišlerová I., Monti D., Cinti S., Naitana M. L., Schiaffino M., Venanzi M., Laguzzi G., Luvidi L., Mancini G., Nováková Z., Šimák O., Wimmer Z., Drašar P.: Spectroscopic, morphological, and mechanistic investigation of the solvent-promoted aggregation of porphyrins modified in meso positions by glucosylated steroids, Eur. J. 2011, 17, 13743-13753.
- Jurček O., Ikonen S., Buřičová L., Wimmerová M., Wimmer Z., Drašar P., Horníček J., Gandaláková A., Ulrichová J., Kolehmainen E. T.: Succinobucol’s new coat – Conjugation with steroids to alter drug effect and bioavailability, Molecules 2011, 16, 9404-9420.
- Šusteková J., Drašar P., Šaman D., Wimmer Z.: Stigmasterol-based novel low molecular weight / mass organic gelators, Molecules 2011, 16, 9357-9367.
- Opletal L., Wimmer Z., Čopíková J., Lapčík O., Moravcová J., Cahlíková L., Drašar P.: Slaná chuť přírodních látek a jejich derivátů, Listy 2011, 105, 761-765.
- Brabcová J., Hanus R., Tykva R., Vlasáková V., Černý B., Wimmer Z., Zarevúcka M.: Degradation of juvenogens by termites and soil bacteria, Biochem. Physiol. 2011, 101, 103-108.
- Svobodová H., Nonappa, Wimmer Z., Kolehmainen E.: Design, synthesis and stimuli responsive gelation of novel stigmasterol-amino acid conjugates, Colloid Interf. Sci. 2011, 361, 587-593.
- Stránský K., Valterová I., Kofroňová E., Urbanová K., Zarevúcka M., Wimmer Z.: Non-polar lipid components of human cerumen, Lipids 2011, 46, 781-788.
- Štěpánek P., Šimák O., Nováková Z., Wimmer Z., Drašar P.: Asymmetrically substituted calix[4]pyrrole with chiral substituents, Biomol. Chem. 2011, 6, 682-683.
- Svobodová H., Ryšavá H., Pavlík M., Šaman D., Wimmer Z.: Steroid conjugates: Synthesis and preliminary biological testing of pro-juvenoids, Med. Chem. 2010, 18, 8194-8203.
- Pavlík M., Ryšavá H., Wimmer Z.: Metabolism of insect ecdysteroids and significance of insect intestinal microbiota, Listy 2010, 104, 831-837.
- Ryšavá H., Štursa P., Kurzawová V., Pavlík M., Wimmer Z., Macková M., Ryšánek P.: Identifikace kultivovatelných střevních bakterií ruměnice pospolné (Pyrrhocoris apterus). Sborník recenzovaných příspěvků kategorie Věda má budoucnost (Maršálek R., Ed.), Přírodovědecká fakulta, Ostravská universita v Ostravě, 2010, pp. 62-65. ISBN: 978-80-7368-719-9.
- Sajfrtová M., Ličková I., Wimmerová M., Sovová H., Wimmer Z.: b-Sitosterol: Supercritical carbon dioxide extraction from sea buckthorn (Hippophae rhamnoides) seeds, Int. J. Mol. Sci. 2010, 11, 1842-1850.
- Wimmer Z., Zarevúcka M.: A review on the effect of supercritical carbon dioxide on enzyme activity, J. Mol. Sci. 2010, 11, 233-253.
- Šobotník J., Hanus R., Piskorski R., Urbanová K., Wimmer Z., Weyda F., Vytisková B., Sillam-Dussès D.: Impact of a juvenile hormone analogue on the anatomy and the frontal gland secretion of Prorhinotermes simplex (Isoptera: Rhinotermitidae), Insect Physiol. 2010, 56, 65-72.
- Ryšavá H., Pavlík M., Wimmer Z., Jurček O., Svobodová H., Ryšánek P.: Biologická účinnost nových typů analogů juvenilních hormonů testovaných na ruměnici pospolné (Pyrrhocoris apterus). Aktuální poznatky v pěstování, šlechtění, ochraně rostlin a zpracování produktů. Výzkumný ústav pícninářský, spol. s r.o. Troubsko. Úroda 2009, 209-212. ISSN: 0139-6013.
- Jurček O., Wimmer Z., Bennettová B., Moravcová J., Drašar P., Šaman D.: Novel juvenogens (insect hormonogenic agents): Preparation and biological tests on Neobellieria bullata, Agric. Food Chem. 2009, 57, 10852-10858.
- Hlavsová K., Zarevúcka M., Wimmer Z., Macková M., Sovová H.: Geotrichum candidum 4013: Extracellular lipase versus cell-bound lipase from the single strain, Mol. Catal. B: Enzym. 2009, 61, 188-193.
- Jurček O., Wimmer Z., Svobodová H., Bennettová B., Kolehmainen E., Drašar P.: Preparation and preliminary biological screening of cholic acid–juvenoid conjugates, Steroids 2009, 74, 779-785.
- Zarevúcka M., Wimmer Z.: Chapter IV: Application of lipases to substances with pharmacological importance (polyunsaturated fatty acids). In: Biocatalysis Research Progress (Romano H. F., Russo A., Eds.), 2008, pp. 155-185. ISBN: 978-1-60456-619-2.
- Zarevúcka M., Wimmer Z.: Plant products for pharmacology: Application of enzymes in their transformations, J. Mol. Sci. 2008, 9, 2447-2473.
- Novák J., Tykva R., Wimmer Z., Pavlík M., Prouza M., Hlavsová K., Zarevúcka M.: Enantiomeric purity of biodegradation products of juvenogens by newly isolated soil bacteria, Agric. Food Chem. 2008, 56, 6604-6608.
- Hlavsová K., Wimmer Z., Xanthakis E., Bernášek P., Sovová H., Zarevúcka M.: Lipase activity enhancement by SC-CO2 treatment, Naturforsch. B 2008, 63, 779-784.
- Tykva R., Černý B., Wimmer Z., Hanus R.: Distribution of a juvenogen and its metabolites in a laboratory system during juvenogen-induced caste differentiation in a termite Reticulitermes santonensis (Isoptera: Rhinotermitidae). Pest Sci. 2008, 64, 654-659.
- Jurček O., Wimmerová M., Wimmer Z.: Selected chiral alcohols: Enzymic resolution and reduction of convenient substrates, Chem. Rev. 2008, 252, 767-781.
- Wimmer Z., Pechová L., Sīle L., Šaman D., Jedlička P., Wimmerová M., Kolehmainen E.: Glycosidic juvenogens: Derivatives bearing a,b-unsaturated ester functionalities, Med. Chem. 2007, 15, 7126-7137.
- Jedlička P., Hrdý I., Kuldová J., Wimmer Z.: The systemic effects of juvenoids on the red firebug Pyrrhocoris apterus and on the pea aphid Acyrthosiphon pisum with data on life table response, Pest Sci. 2007, 63, 1026-1035.
- Wimmer Z., Jurček O., Jedlička P., Hanus R., Kuldová J., Hrdý I., Bennettová B., Šaman D.: Insect pest management agents: Hormonogen esters (juvenogens), Agric. Food Chem. 2007, 55, 7387-7393.
- Wimmer Z., Floro A. J. F. D. M., Zarevúcka M., Wimmerová M., Sello G., Orsini F.: Insect pest control agents: Novel chiral butanoate esters (juvenogens), Med. Chem. 2007, 15, 6037-6042.
- Stránský K., Zarevúcka M., Kejík Z., Wimmer Z., Macková M., Demnerová K.: Substrate specificity, regioselectivity and hydrolytic activity of lipases activated from Geotrichum sp., Eng. J. 2007, 34, 209-216.
- Xanthakis E., Zarevúcka M., Šaman D., Wimmerová M., Kolisis F. N., Wimmer Z.: Application of ionic liquids in enzymic resolution by hydrolysis of cycloalkyl acetates, Tetrahedron: Asym. 2006, 17, 2987-2992.
- Šaman D., Kratina P., Moravcová J., Wimmerová M., Wimmer Z.: Synthesis and structure assignment of 2-(4-methoxybenzyl)cyclohexyl b-d-glucopyranoside enantiomers, Czech. Chem. Commun. 2006, 71, 1470-1483.
- Stránský K., Zarevúcka M., Valterová I., Wimmer Z.: Gas chromatographic retention data of wax esters, Chromatogr. A, 2006, 1128, 208-219.
- Šaman D., Wimmerová M., Wimmer Z.: Synthesis and structure assignment of 2-(4-methoxybenzyl)cyclohexyl b-d-galactopyranoside stereoisomers, Czech. Chem. Commun. 2006, 71, 1186-1198.
- Hrdý, Kuldová J., Hanus R., Wimmer Z.: Juvenile hormone III, hydroprene and a juvenogen as soldier caste differentiation regulators in three Reticulitermes species: potential of JHAs in termite control. Pest Manag. Sci. 2006, 62, 848-854.
- Wimmer Z., Kuldová J., Hrdý I., Bennettová B.: Can juvenogens, biochemically targeted hormonogen compounds, assist in environmentally safe insect pest management? Insect Biochem. Mol. Biol. 2006, 36, 442-453.
Education: |
|
|
1966-71 |
Charles University Prague, Faculty of Natural Sciences, programme Organic Chemistry |
|
1971-72 |
Charles University Prague, Faculty of Natural Sciences, postgraduate study, RNDr. |
|
1974-77 |
PhD study at the Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, CSc. |
|
2004 |
Scientific degree DSc. awarded by Scientific Council of the Czech Academy of Sciences |
Professional life: |
|
|
1971-1972 |
Assistant professor, Charles University Prague, Faculty of Natural Sciences |
|
1972-2002 |
Researcher, Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, CSc. |
|
2001-2004 |
Part-time teacher at Palacky University Olomouc |
|
2002-2004 |
Associate professor, Department of Chemistry of Natural Compounds, UCT Prague |
|
2004- |
Professor, Department of Chemistry of Natural Compounds, UCT Prague |
|
Teaching: |
|
|
|
Selected chapters from Chemistry of natural compounds |
|
|
Special analysis of natural compounds |
|
|
Seminar of molecular modeling |
|
|
Biologically active natural compounds |
Subjects of interest: |
|
|
|
Chemistry of natural compounds |
|
|
Synthesis of steroid heterocycles and non-hormone active steroids |
|
|
Isolation and modification of terpenoids |
|
|
Synthesis of supramolecular systems based on chiral natural compounds |
Fellowships |
|
|
1974 |
Institute of Organic Synthesis, Academy of Sciences, Riga, Latvia |
|
1984-5 |
Arizona State University, Cancer Research Institute, Tempe, Arizona, USA |
|
1987 |
Institute of Bio-Organic Chemistry, Minsk, Belarus |
Projekty řešené v současné době:
- Projekt COST v akci CM1304 Emergence and Evolution of Complex Chemical Systems, 2013-2017
- Grant GA ČR 14-04329S Vztah mezi biologickou aktivitou a intracelulární lokalizací seskviterpenových laktonů, 2014-2016
- Grant ESF CZ.1.07/2.3.00/30.0060 Propojení výzkumu a vzdělávání v oblasti medicinální chemie, 2013-2015
- Grant GA ČR P106/12/0569 Membránové separace - efektivnější separace čistých enantiomerů z racemických směsí, 2012-2015.
- 2015 Grant Programu bezpečnostního výzkumu České republiky VG20112015045, Vývoj rychlých imunochemických testů pro detekci anabolicky aktivních steroidů, 2011-2015.
- Grant fy Contipro Biotech sro 99-103 Syntéza peptidů na nosičích, 2013-2014.
Projekty vyřešené:
- Grant GA ČR P304/10/01951, Nanoliposomy pro vývoj rekombinantních vakcín a cílených imunoterapeutik, 2010-2013.
- Projekt Národního výzkumného programu II MŠMT , Supramolekulární materiály na bázi přírodních fytosterolů pro využití v biologii (SUPRAFYT) č. 2B06024, 2006-2011.
- Grant NATO na projekt: Development of chemical sensors with tailored sensitivity, č. CBP.EAP.CLG.982972, 2007-2011.
- Grant GA ČR 203/06/0006, Syntéza a studium chirálních supramolekulárních synthonů (SSCSS), 2006-2009.
- Grant MŠMT na projekt COST v akci D-31, Organising Non-Covalent Chemical Systems with Selected Functions, s názvem: Přírodní látky jako modifikátory funkčnosti nekovalentních supramolekulárních systémů II; Natural Products as Function Modifiers in Non-Covalent Supramolecular Systems II (NPFM-II) č. OC08043, 2008-2009.
- Projekt COST v akci D-31: Organising Non-Covalent Chemical Systems with Selected Functions, s názvem: Přírodní látky jako modifikátory funkčnosti nekovalentních supramolekulárních systémů; Natural Products as Function Modifiers in Non-Covalent Supramolecular Systems (NPFM) č. 1P04OCD31.001, 2004-2007.
- Výzkumný projekt MZE QF-3115, DNA-vakcíny, Vývoj vektorů, nosičů a adjuvans pro konstrukci DNA vakcín, 2003-2006.
- Rozvojový projekt pro VVŠ MŠMT č. 605, program 2 podprogram b, Implementace evropských strukturálních prvků ve studiu chemie na VŠCHT Praha a prohloubení účasti VŠCHT Praha v mezinárodních aktivitách směřujících k rozvoji studia chemie v Evropě, 2005.
- Jurášek M, Rimpelová S, Kmoníčková E, Drašar P, Ruml T: Tailor-Made Fluorescent Trilobolide To Study Its Biological Relevance, JOURNAL OF MEDICINAL CHEMISTRY 57, 7947 (2014). DOI: 10.1021/jm500690j
- Lorecchio C., Venanzi M., Mazzuca C., Lettieri R., Palleschi A., Nguyen Thi T. H., Cardova L., Drasar P., Monti D.: ORGANIC & BIOMOLECULAR CHEMISTRY 12, 3956 (2014). DOI: 1039/C4OB00134F
- Bildziukevich U., Rarova L., Saman D., Havlicek L., Drasar P., Wimmer Z.: STEROIDS 78, 1347 (2013). DOI: 10.1016/j.steroids.2013.10.003
- Vinš P, Vermachová M, Drašar P, del Barrio M, Jarne C, Cebolla VL, de Cózar A, Zangi R, Cossío FP: Size and branching effects on the fluorescence of benzylic dendrimers possessing one apigenin fluorophore at the core TETRAHEDRON 69 10361-10368 (2013); http://dx.doi.org/10.1016/j.tet.2013.10.002
- Zhylitskaya, H; Litvinovskaya, R; Baranovsky, A; Eigner, V; Kratochvil, B; Drasar, P; Khripach, V: Regio- and stereocontrolled synthesis of novel steroidal isoxazolines: A new route to the formation of selectively modified steroid side chains STEROIDS 78, 823-831 (2013); DOI: 10.1016/j.steroids.2013.04.017.
- Mrozek, L; Coufalova, L; Rarova, L; Placek, L; Opatrilova, R; Dohnal, J; Kralova, K; Paleta, O; Kral, V; Drasar, P; Jampilek, J: New polyfluorothiopropanoyloxy derivatives of 5 beta-cholan-24-oic acid designed as drug absorption modifiers STEROIDS 78, 832-844 (2013); DOI: 10.1016/j.steroids.2013.05.012.
- Naitana, ML; Dukh, M; Zelenka, K; Trnka, T; Venanzi, M; Lettieri, R; Drasar, P; Monti, D: The kinetic studies of the solvent-promoted aggregation of a steroid-porphyrin derivative JOURNAL OF PORPHYRINS AND PHTHALOCYANINES 17, 889-895 (2013); DOI: 10.1142/S1088424613500831
- Jurasek, M.; Rimpelova, S.; Kmonickova, E.; Drasar, P; Ruml, T: Biological relevance of fluorescent trilobolide conjugates FEBS JOURNAL 280, SI/1, 342-342 (2013).
- Khripach, VA; Tarkowska, D; Zhabinskii, VN; Gulyakevich, OV; Ermolovich, YV; Drasar, P; Strnad, M: Synthesis and Mass Spectral Fragmentation Patterns of Brassinolide Early Biosynthetic Precursors Labeled at C-26 NATURAL PRODUCT COMMUNICATIONS 8, 771-774 (2013).
- Coufalova, L; Mrozek, L; Rarova, L; Placek, L; Opatrilova, R; Dohnal, J; Kral'ova, K; Paleta, O; Kral, V; Drasar, P; Jampilek, J: New propanoyloxy derivatives of 5 beta-cholan-24-oic acid as drug absorption modifiers STEROIDS 78, 435-453 (2013); DOI: 10.1016/j.steroids.2013.02.001.
- Jurasek, M; Dzubak, P; Sedlak, D; Dvorakova, H; Hajduch, M; Bartunek, P; Drasar, P: Preparation, preliminary screening of new types of steroid conjugates and their activities on steroid receptors STEROIDS 78, 356-361 (2013); DOI: 10.1016/j.steroids.2012.11.016
- Khripach, VA; Zhabinskii, VN; Konstantinova, OV, Tsavlovskii, DV; Baranovsky, AV; Lyakhov, AS; Drasar, P; Synthesis, crystal structure and NMR investigation of a new type of cyclic steroidal dimer based on brassinosteroids JOURNAL OF MOLECULAR STRUCTURE 1032, 1-4 (2013); DOI: 10.1016/j.molstruc.2012.07.001.
- Lettieri R.; Monti D.; Zelenka K., Trnka T., Drašar P., Venanzi M. Glucosylated steroid-porphyrins as new tools for nanotechnology applications NEW JOURNAL OF CHEMISTRY 36, [5], 1246-1254 (2012) DOI: 10.1039/c2nj20982a
- Zelenka K., Trnka T., Tišlerová I., Monti D., Cinti S., Naitana ML., Schiaffino L., Venanzi M., Laguzzi G., Luvidi L., Mancini G., Nováková Z., Šimák O., Wimmer Z., Drasar P. Spectroscopic, Morphological, and Mechanistic Investigation of the Solvent-Promoted Aggregation of Porphyrins Modified in meso-Positions by Glucosylated Steroids. CHEMISTRY-A EUROPEAN JOURNAL 17, [49], 13743-13753 (2011) DOI: 10.1002/chem.201101163
- Šusteková J., Drašar P., Šaman D., Wimmer Z. Stigmasterol-Based Novel Low Molecular Weight/Mass Organic Gelators Molecules 16, [11], 9357-9367 (2011). DOI: 10.3390/molecules16119357
- Mrozek L., Dvořáková L., Mandelová Z., Rárová L., Řezáčová A., Plaček L., Opatřilová R., Dohnal J., Paleta O., Král V., Drašar P., Jampílek J. Investigation of new acyloxy derivatives of cholic acid and their esters as drug absorption modifiers STEROIDS 76, [10-11], 1082-1097 (2011). DOI: 10.1016/j.steroids.2011.04.014
- Nováková Z., Tomanová J., Štěrbová L., Drašar P. Steroid and bile acids amide conjugates with D-glucosamine, COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS 76, [1], 65-74 (2011) DOI: 10.1135/cccc2010105
- Čopíkova J., Moravcová J., Lapčík O., Opletal L., Drašar P. Přírodní látky a jejich deriváty chuti chladivé (Natural Compounds with Cooling Taste and Their Derivatives) Chemicke Listy 105, [12], 938-942 (2011).
- Lapčík O., Opletal L., Moravcová J., Čopíková J., Drašar P. Přírodní látky a jejich deriváty chuti pálivé (Natural Compounds and Their Derivatives of Hot or Pungent Taste) CHEMICKE LISTY 105, [6], 452-457 (2011).
- Štěpánek P., Šimák O. Nováková Z., Wimmer Z., Drašar P.: Asymmetrically substituted calix[4]pyrrole with chiral substituents. ORGANIC & BIOMOLECULAR CHEMISTRY 9 [3], 682-683 (2011).1477-0520.
- Svobodová H., Ryšavá H., Pavlík M., Šaman D., Drašar P., Wimmer Z.: Steroid conjugates: Synthesis and preliminary biological testing of pro-juvenoids. BIOORGANIC & MEDICINAL CHEMISTRY 18 [23], 8194-8203 (2010).
- Drašar P., Přichystalová T., Wimmer Z., Ledvina M. Drasar L.: Steroidní amidy odvozené od sperminu a způsob jejich přípravy. CZ PV 2010-606 (2010).
- Musilová J., Barek J., Drašar P., Peckova K.: Differential Pulse Voltametry of Selected Nitrophenols on Boron-Doped Diamond Film Electrode. SENSING IN ELECTROANALYSIS 4, 135-142 (2009).
- Jurcek, O., Wimmer, Z. , Bennettova, B., Moravcova, J., and Drasar, P. Novel Juvenogens ( Insect Hormonogenic Agents): Preparation and Biological Tests on Neobellieria bullata. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 57 [22], 10852-10858 (2009).
- Hampl F., Moravcová J., Čopíkova J., Opletal L., Lapčík O., Drašar P.: Krása a diversita přírodních antibiotik (Beauty and Diversity of Natural Antibiotics). CHEMICKE LISTY 103 [1], 15-27 (2009).
- Černý I., Buděšínský M., Pouzar V., Drasar P.: Steroids linked with amide bond-Extended cholesterol. STEROIDS 74 [1], 88-94 (2009).
- Drašar, P.: O atributech chemického vzdělávání (The attributes of chemical education). CHEMICKE LISTY 103 [5], 371-372 (2009).
- Huong N. T. T., Klímková P., Sorrenti A., Mancini G., Drasar P.: Synthesis of spiroannulated oligopyrrole macrocycles derived from lithocholic acid. STEROIDS 74 [8], 715-720 (2009).
- Jurček O., Wimmer Z. , Svobodová H., Bennettová B., Kolehmainen E., Drašar P. Preparation and preliminary biological screening of cholic acid-juvenoid conjugates. STEROIDS 74 [9], 779-785 (2009).
- Raichyonok T. F., Khripach V. A., Zhabinskii V. N., Konstantinova O. V., Drašar P. B., Monti D.: Synthesis and Spectral-Luminescence Properties of the Conjugate of 24-Epibrassinolide with Porphyrin. JOURNAL OF APPLIED SPECTROSCOPY 76 [4], 542-546 (2009). ZHURNAL PRIKLADNOI SPEKTROSKOPII 76 [4], 571-575 (2009).
- Monti D., Venanzi M. , Gatto E., Mancini G., Sorrenti A., Štěpánek P., Drašar, P.: Study of the supramolecular chiral assembly of meso-"C-glucoside"-porphyrin derivatives in aqueous media. New Journal of Chemistry 32 [12], 2127-2133 (2008).
- Drašar P., Nguyen T. T. H., Klímková P.: Mono-spiroanelované makrocykly odvozené od lithocholové kyseliny a způsob jejich výroby. CZ PV 2008-367 [300168] (2008).
- Drašar P., Trnka T., Zelenka K.: Oligopyrrolové makrocykly substituované v meso-polohách glykosylovanými steroidy a jejich příprava. CZ PV 2008-27 (2008).
- Rumlerová-Lipšová A., Barek J., Drašar P., Zelenka K., Pecková K.: Polarographic and voltammetric determination of meso-tetrakis(4-sulfonatophenyl) porphyrin tetrasodium salt at mercury electrodes. International Journal of Electrochemical Science 2 [3], 235-247 (2007).
- Drašar P., Nguyen T. T. H., Klimková P.: Syntéza methyl (5beta)-3,3-di-1H-pyrrol-2-ylcholan-24-oátu. CZ PV 2007-868 [300167] (2007).
- Drašar P., Nguyen T. T. H., Klimková P.: Bis-spiroanelované oligopyrrolové makrocyklů odvozených od lithocholové kyseliny a způsob jejich výroby. CZ PV [300167] 2007-869 (2007).
- Opletal L., Čopíková J., Uher M., Lapčík O., Moravcová J., Drašar P.: Přírodní látky hořké chuti (Natural Compounds of Bitter Taste). Chemicke Listy 101 [11], 895-906 (2007).
- Štěpánek P., Dukh M., Šaman D., Moravcová J., Kniežo L., Monto D., Venanzi M., Mancini G., Drašar P.: Synthesis and solvent driven self-aggregation studies of meso-“C-flycoside”-porphyrin derivatives, Org. Biomol. Chem., 2007, 5, 960-970.
- Lapčík O., Čopíková J., Uher M., Moravcová J., Drašar P., Necukerné přírodní látky sladké chuti (Sweet Non-Saccharide Natural Compounds), Chem. Listy, 2007, 101, 44-54.
- Čopíková J., Lapčík O., Uher M., Moravcová J., Drašar P., Cukerná nesacharosová sladidla a příbuzné látky (Non-Sucrose Saccharide Sweeteners and Related Compounds), Chem Listy, 2006, 100, 778-783.
- Čopíková J., Uher M., Lapčík O., Moravcová J., Drašar P., Přírodní barevné látky (Natural Colorants), Chem. Listy, 2005 , 99, 802-816
- Drašar P., Buděšínský M., Reschel M., Pouzar V., Černý I.: Etienic etienate as synthon for the synthesis of steroid oligoester gelators, Steroids, 2005, 70, 615-625.
- Drašar P., Moravcová J.: Recent advances in analysis of Chinese medical plants and traditional medicines, Journal of Chromatography B, 2004, 812, 3–21.
- Zelenka K., Trnka T., Tišlerová I., Král V., Dukh M., Drašar P.: Synthesis of porphyrin receptors modified by glycosylated steroids, Coll. Czech. Chem. Commun. 2004, 69, 1169.
- Dukh M., Šaman D., Lang K., Pouzar V., Černý I., Drašar P., Král V.: Steroid porphyrin conjugate for saccharide sensing in protic media. Org. Biomol. Chem. 2003, 1, 3458-3463.
- Dukh M., Šaman D., Kroulík J., Černý I., Pouzar V., Král V., Drašar P.: Metal Coordination as a Tool for Controlling the Self-Assembling and Gelation Properties of Novel Type Cholic Amide-Phenanthroline Gelating Agent. Tetrahedron 2003, 59, 4069-4076.
- Drašar P., Valter B., Paleta O.; Grafické vyjádøení chirality chemických slouèenin Chem. Listy 2003, 97, 1027–1046.
- Dukh M., Drašar P., Černý I., Pouzar V., Shriver J. A., Král V., Sessler J. L.: Novel Deep Cavity Calix[4]pyrroles Derived from Steroidal Ketones. Supramolecular Chemistry, 2002, 14, 237-244.
- Reschel M., Buděšínský M., Černý I., Pouzar V., Drašar P.: Synthesis of Linear Steroid Oligoesters Based on Etienic Acid. Collect. Czech. Chem. Commun. 2002, 67, 1709-1718.
- Dukh M., Černý I., Urbanský M., Pouzar V., Král V., Drašar P.: Polycyklické makrocykly obsahující pyrrol s pøímo vázanými steroidními substituenty v mesopolohách, Czech Pat. 2002, 290491, Appl. 1999, 3098-99.
- Kamano Y, Nogawa T, Yamashita A, Hayashi M, Inoue M, Drašar P, and Pettit GR; Isolation and Structure of a 20,21-Epoxybufenolide Series from "Ch'an Su", J. Nat. Prod. 2002, 65, 1001.
- Černý I, Budešínský M, Pouzar V, Drašar P: Linear chaining of etienic acid derivatives with the amide bond. Synthesis of oligomeric steroids, Coll. Czech. Chem. Commun. 2001, 66, 933.
- Pacák, J. and Drašar, P.; Výuka sacharidù a její didaktická úsilí (Didactical problems of Teaching of Saccharides). Chemicke listy 2001, 95(10), 665-669.
- Urbanský M, Proška J, Drašar P.: Fused thiazoloandrostanes and their quaternary salts, synthesis and cooperative ligand binding to muscarinic acetylcholine receptor, Coll. Czech. Chem. Commun. 1999, 64, 1457.
- Kamano Y, Kotake A, Nogawa T, Hashima H, Tozawa M, Morita H, Takeya K, Itokawa H, Matsuo I, Ichihara Y, Drasar P, Pettit GR: Conformational preference of two toad poison bufadienolides, cinobufagin and bufotalin, Coll. Czech. Chem. Commun. 1998, 63, 1663.
Education |
|
|
1984 – 1989 |
Charles University Prague, Faculty of Science, programme Biochemistry |
|
1993 – 1998 |
Doctoral study at the Department of Biochemistry, Charles University Prague, programme Biochemistry, PhD thesis „Radioimmunoassay of Isoflavonoid Phytoestrogens“, supervisor prof. RNDr. Richard Hampl, DrSc. |
Employment |
|
|
1980 – 1982 |
General University Hospital Prague, Hemodialysis Center Strahov, hospital attendant |
|
1982 – 1984 |
Military service |
|
1984 – 1989 |
General University Hospital Prague, Hemodialysis Center Strahov,, hospital attendant (part-time job while studying) |
|
1989 – 2001 |
Institute of Endocrinology, Prague |
|
2002 – |
Department of Chemistry of Natural Compounds, UCT Prague, assistant professor (2002-6), associate professor (2006-9), professor (since 2009) |
|
2007 – |
Department of Chemistry of Natural Compounds, UCT Prague, head of the department |
Teaching |
|
|
|
Plant-based theraputics and traditional medicine |
|
|
Bioactive Natural Compounds |
|
|
|
Professional interest |
|
|
|
Biologically active natural compounds and their analogues (steroids, terpenoids, flavonoids and polyphenols) |
|
|
Imunoanalytical and instrumental methods for the determination of low-molecular compounds |
|
|
Application of developed methods in phytochemistry, endocrinology and forensic science |
Fellowships |
|
|
1992 |
Department of Physiology, University of Turku, Finland |
|
1993 |
Institut fur Biochemische Endokrinologie, Medizinische Universitet, Lubeck, Germany |
|
1993 |
Department of Clinical Chemistry, University of Helsinki, Finsko |
|
1996 |
Huddinge University Hospital, Karolinska Institute, Huddinge, Sweden |
|
1998 |
Department of Physiology, University of Turku, Finland |
Mikšátková P., Ancheeva E., Hejtmánková K., Teslov L., Lapčík O. (2014) Determination of Flavonoids in Stellaria by High-Performance Liquid Chromatography–Tandem Mass Spectrometry. Analytical Letters, 47: 2317–2331.
Mikšátková P., Lanková P., Huml L., Lapčík O. (2014) Isoflavonoids in the Amaryllidaceae family. Nat. Prod. Res. 28 (10), 690-697.
Pičmanová M, Reňák D, Pleskot R, Feciková J, Mikšátková P, Lapčík O, Honys D (2013) Polymorphic protein CYP93C18 is responsible for the endoplasmic reticulum membrane-associated isoflavone synthase activity in pea. Biologia Palntarum 57 (4), 635-645.
Leuner O., Havlik J., Budešínský M., Vrkoslav V., Chu J., Bradshaw T. D., Hummelová J., Mikšátková P., Lapčík O., Valterová I., Kokoška L. (2013) Cytotoxic constituents in Pachyrhizus tuberosus from Peruvian Amazon. Nat. Prod. Commun. 8 (10), 1423-1426.
Holubová B., Goselová S., Ševčíková L., Vlach M., Blažková M., Lapčík O., Fukal L. (2013) Rapid Immunoassays for Detection of Anabolic Nortestosterone in Dietary Supplements. Czech J. Food Sci 31 (5), 514-519.
Abdulmanea K., Prokudina E.A., Lanková P., Vaníčková L., Koblovská R., Zelený V., Lapčík O. (2012) Immunochemical and HPLC identification of isoflavonoids in the Apiaceae family. Biochem. Syst. Ecol. 45, 237–243.
Prokudina E.A., Havlíček L., Al-Maharik N., Lapčík O., Strnad M., Gruz J. (2012) Rapid UPLC–ESI–MS/MS method for the analysis of isoflavonoids and other phenylpropanoids. J Food Comp. Anal. 26(1-2), 36-42.
Sosvorová L., Mikšátková P., Bičíková M., Kaňová N., Lapčík O. (2012) The presence of monoiodinated derivates of daidzein and genistein in human urine and its effect on thyroid gland function. Food Chem. Toxicol. 50(8) 2774-2779.
Prokudina E.A., Lanková P., Koblovská R., Al-Maharik N., Lapčík O. (2011) Development of sorbents for immunoaffinity extraction of isoflavonoids. Phytochem. Lett. 4, 113–117.
Sosvorová L., Lanková L., Bičíková M., Prokudina E.A., Al-Maharik N., Lapčík O. (2011) ELISA for Free S-equol in Human Urine. Czech J. Food Sci, 29: 65-72.
Hampl R. Ostatníková D., Celec P., Putz Z., Lapčík O., Matucha P. (2008) Short-term effect of soy consumption on thyroid hormone levels and correlation with phytoestrogen level in healthy subjects. Endocr Regul. 4(2):53-61.
Koblovská R., Macková Z., Vítková M., Kokoška L., Klejdus B., Lapčík O. (2008) Isoflavones in the Rutaceae family: Twenty selected representatives of the genera Citrus, Fortunella, Poncirus, Ruta and Severinia. Phytochem. Analysis 19: 64-70.
Klejdus B., Vacek J., Benešová L., Kopecký J., Lapčík O., Kubáň V. (2007) Rapid-resolution HPLC with spectrophotometric detection for determination and identification of isoflavones in soy preparations and plant extracts. Anal. Bioanal. Chem. 389: 2277–2285.
Zamrazilová L., Kazihnitková H., Lapčík O., Hill M., Hampl R. (2007) A Novel Radioimmunoassay of 16α-Hydroxy-Dehydroepiandrosterone and its Physiological levels. J. Steroid Biochem. Molec. Biol. 104: 130-135.
Včeláková H., Hill M., Lapčík O., Pařízek A. (2007) Determination of 17α-hydroxypregnenolone sulfate and its application in diagnostics. Steroids, 72: 323-327.
Kazihnitková H., Zamrazilová L., Hill M., Lapčík O., Pouzar V. Hampl R. (2007) A novel radioimmunoassay of 7-OXO-DHEA and its physiological levels. Steroids, 72: 342-350
Milerová J., Čeřovská J, Zamrazil V., Bílek R., Lapčík O., Hampl R. (2006) Actual levels of soy phytoestrogens correlate with thyroid laboratory parameters. Clin. Chem. Lab. Med. 44: 171-174.
Lapčík O., Honys D., Koblovská R., Macková Z., Vítková M., Klejdus B. (2006) Isoflavonoids are present in Arabidopsis thaliana despite the absence of any homologue to known isoflavonoid synthases. Plant Physiol. Biochem 44: 106-114.
Klejdus B., Lojková L., Lapčík O., Koblovská R., Moravcová J., Kubáň V. (2005) Supercritical fluid extraction of isoflavones from biological samples with ultra-fast high-performance liquid chromatography/mass spectrometry. J. Sep. Sci. 28: 1334–1346.
Lapčík O., Klejdus B., Kokoška L., Davidová M., Afandi K., Kubáň V., Hampl R. (2005) Identification of isoflavones in Acca sellowiana and two Psidium species (Myrtaceae) Biochem. Syst. Ecol. 33: 983-992.
Lapčík O., Vítková M, Klejdus B., Al-Maharik N., Adlercreutz H. (2004) Immunoassay for biochanin A. J. Immunol. Methods 294: 155-163.
Lapčík O., Klejdus B., Davidová M., Kokoška L., Kubáň V., Moravcová J. (2004) Isoflavonoids in the Rutaceae family: 1. Fortunella obovata, Murraya paniculata and four Citrus species. Phytochem. Analysis 9: 293-299.
Lapčík O., Štursa J., Kleinová T., Vítková M., Dvořáková H., Klejdus B., Moravcová J. (2003) Synthesis of hapten and conjugates of coumestrol and development of immunoassay. Steroids 68: 1147-1155.
Brouwers E., L´Homme R., Al-Maharik N., Lapčík O., Hampl R., Wahala K., Mikola H., Adlercreutz H. (2003) Time-resolved fluoroimmunoassay for equol in plasma and urine. J. Steroid Biochem. Molec. Biol. 84: 577-588.
Pouzar V., Černý I., Lapčík O., Hill M., Hampl R. (2003) Synthesis of two new haptens of 16 alpha – hydroxydehydroepiandrosterone (3 beta, 16 alpha- dihydroxyandrost-5en-17-one). Steroids 68: 149-158.
Hill M., Pařízek A., Klak J., Hampl R., Šulcová J., Havlíková H., Lapčík O., Bičíková M., Fait T., Kantcheva R. Cibula D., Pouzar V., Meloun M., Stárka L. (2002) Neuroactive steroids, their precursors and polar conjugates during parturition and postpartum in maternal and umbilical blood: 3,3b-hydroxy-5-ene steroids. J. Steroid Biochem. Molec. Biol. 82: 241-250.
L´homme R., Brouwers E., Al-Maharik N., Lapčík O., Hampl R., Mikola H., Wähälä K., Adlercreutz H. (2002) Time-resolved fluoroimmunoassay of plasma and urine O-desmethylangolensin. J. Steroid Biochem. Molec. Biol. 81: 353-361.
Hill M., Lapčík O., Havlíková H., Morfin R., Hampl R. (2001) 7-Hydroxy-dehydroepiandrosterone epimers in human serum and saliva: Comparison of gass chromatography-mass spectrometry and radioimmunoassay. J. Chromatography A. 935: 297-307.
Uehara M., Lapčík O., Hampl R., Al-Maharik N., Makala T., Wähälä K., Mikola H., Adlercreutz H. (2000) Rapid analysis of phytoestrogens in human urine by time-resolved fluoroimmunoassay. J. Steroid Biochem. Molec. Biol. 72: 273-282.
Wang G.J., Lapčík O., Hampl R., Uehara M., Al-Maharik N., Stumpf K., Mikola H., Wähälä K., Adlercreutz H. (2000) Time-resolved fluoroimmunoassay of plasma daidzein and genistein. Steroids 65: 339-348.
Lapčík O., Hampl R., Hill M., Stárka L. (1999): Immunoassay of 7-hydroxysteroids: 2. Radioimmunoassay of 7a-hydroxy-dehydroepiandrosterone. J. Steroid Biochem. Molec. Biol. 71: 231-237.
Lapčík O., Hill M., Černý I., Lachman J., Al-Maharik N., Adlercreutz H., Hampl. R. (1999) Immunoanalysis of isoflavonoids in Pisum sativum and Vigna radiata. Plant Science 148: 111-119.
Hill M., Lukáč D., Lapčík O., Šulcová J., Hampl R., Pouzar V., Stárka L. (1999) Age Relationships and Sex Differences in Serum Levels of Pregnenolone and 17-Hydroxypregnenolone in Healthy Subjects. Clin. Chem. Lab. Med. 37: 439-447.
Hampl R., Lapčík O., Hill M., Bičíková M., Putz Z., Vaňuga A., Stárka L. (1999) Dehydroepiandrosterone and its 7-hydroxylated metabolites in Hashimoto´s thyroiditis (a preliminary report). The Thyroid Gland 1, 1999, 11-14
Hill M., Hampl R., Lukáč D., Lapčík O., Pouzar V., Šulcová J. (1999) Elimination of cross-reactivity by addition of an excess of crossreactant for radioimmunoassay of 17a-hydroxypregnenolone. Steroids 64: 341-355.
Adlercreutz H., Wang G.J., Lapčík O., Hampl R., Wähälä K., Mäkelä T., Lusa K., Talme M., Mikola H. (1998) Time resolved fluoroimmunoassay for plasma enterolactone. Anal. Biochem. 265: 208-215.
Lapčík O., Hampl R., Hill M., Bičíková M., Stárka L. (1998) Immunoassay of 7-hydroxysteroids: 1. Radioimmunoassay of 7b-Hydroxy Dehydroepiandrosterone. J. Steroid Biochem. Molec. Biol. 67: 439-445.
Lapčík O., Hill M., Hampl R., Wähälä K. , Al-Maharik N. and Adlercreutz H. (1998) Radioimmunoassay of free genistein in human serum J. Steroid Biochem. Molec. Biol. 64: 261-268.
Lapčík O., Hill M., Hampl R., Wähälä K. and Adlercreutz H. (1998) Identification of isoflavonoids in beer. Steroids 63: 14-20.
Lapčík O., Hampl R., Al-Maharik N., Salakka A., Wähälä K., Adlercreutz H. (1997) A novel radioimmunoassay for daidzein. Steroids 62:315-320.
Hill M., Lapčík O.and Hampl R. (1997) Evaluation and separation of steroid-bovine serum albumin conjugates by high-performance liquid chromatography. J. Chromatography B, 691: 187-191.
Stárka L., Hampl R., Hill M., Lapčík O., Bílek R., Petřik R. (1997) Epitestosterone in Human Blood and Prostatic Tissue. Eur. J. Clin. Chem. Clin. Biochem 35, 469-473.
Hill M., Lapčík O., Hampl R., Stárka L.and Putz Z. (1995) Radioimmunoassay of three deoxycorticoids in human plasma following HPLC separation. Steroids 60: 615-620.
Lapčík O. , Hampl R., Hill M. and Stárka L. (1995) Plasma levels of epitestosterone from prepuberty to adult life. J. Steroid Biochem. Molec. Biol. 55: 405-408.
Behre H., Hampl R., Lapčík O., Hill M. and Stárka L. (1995) The effect of epitestosterone on spermatogenesis in rats. Endocrine regulations 29: 195-199.
Bičíková M., Lapčík O., Hampl R., Stárka L., Knuppen R., Haupt O. and Dibbelt L. (1995) A novel radioimmunoassay of allopregnanolone. Steroids 60: 210-213.
Lapčík O., Perheentupa A., Bičíková M., Huhtaniemi I. and Hampl R. (1994) The effect of epitestosterone on gonadotropin synthesis and secretion. J. Endocrinol. 143: 353-358.
Hampl R., Lapčík O., Šulcová J., Stárka L., Kalvachová B., Dvořáková M., Němcová D. and Hoza J. (1994) The effect of long-term glucocorticoid therapy on glucocorticoid receptor content an steroid response on ACTH, J. Steroid Biochem Molec Biol 48 (1): 81-87.
Bičíková M., Kančeva R., Lapčík O. and Stárka L. (1993) The effect of epitestosterone on the plasma levels of LH and FSH in ovariectomized immature rats. J. Steroid Biochem. Molec. Biol. 45: 321-324 (1993) .
Sulková S., Votruba T., Lapčík O. (1990) Beta-2-microglobulin serum levels during dialysis: effect of cuprophan and serum osmolality changes. Int. J. Artif. Org., 13(1): 22-25.
[iduzel] => 9430 [canonical_url] => //uchpl.vscht.cz/kontakt/zamestnaci/oldrichlapcik/9430 [skupina_www] => Array ( ) [url] => /contact/staff/OldrichLapcik/9430 [sablona] => stdClass Object ( [class] => stranka [html] => [css] => [js] => [autonomni] => 1 ) ) ) [iduzel] => 14629 [canonical_url] => //uchpl.vscht.cz/contact/staff/OldrichLapcik [skupina_www] => Array ( ) [url] => /contact/staff/OldrichLapcik [sablona] => stdClass Object ( [class] => stranka [html] => [css] => [js] => [autonomni] => 1 ) ) [14428] => stdClass Object ( [nazev] => Jitka Moravcová [seo_title] => Jitka Moravcová [seo_desc] => Jitka Moravcová Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology UCT Prague University of Chemistry and Technology Prague [autor] => [autor_email] => [obsah] =>
Education: |
|
|
1970 – 1975 |
Institute of Chemical Technology (now: University of Pardubice) Pardubice, master's degree in 1975, organic chemistry |
|
1975 – 1978 |
Postgraduate study at the Department of Organic Chemistry, ICT Pardubice |
|
1979 |
PhD in Chemical Sciences at ICT Pardubice |
Professional life: |
|
|
1980 |
Researcher, Laboratory of Monosaccharides, Institute of Chemical Technology Prague (ICT Prague - now: University of Chemistry and Technology, Prague; UCT Prague) |
|
1991 – 1998 |
Lecturer, Department of Chemistry of Natural Compounds, UCT Prague |
|
1998 - 2005 |
Assistant professor, Department of Chemistry of Natural Compounds, UCT Prague |
|
2005 |
Professor, Department of Chemistry of Natural Compounds, UCT Prague |
|
2000 – 2006 |
Head of the Department of Chemistry of Natural Compounds, UCT Prague |
|
2005 – 2007 |
Vice-rector for research and development, UCT Prague |
|
2010 – 2011 |
Vice-dean for education, Faculty of Food and Biochemical Technology, UCT Prague |
Teaching: |
|
|
|
Lectures for students of all study levels on the isolation and separation of molecules, on the chemistry of biomolecules and scientific communication. Supervisor of PhD theses and diploma theses. |
Subjects of interest: |
|
|
|
Chemistry and stereochemistry of carbohydrates, synthesis of biological active compounds, molecular recognition, chemistry of natural compounds, reaction mechanisms and analytical methods (HPLC, GCL, CE, IR). |
[poduzel] => stdClass Object ( [14433] => stdClass Object ( [nazev] => Info [barva_pozadi] => cervena [uslideru] => false [text] => [iduzel] => 14433 [canonical_url] => [skupina_www] => Array ( ) [url] => [sablona] => stdClass Object ( [class] => infobox [html] => [css] => [js] => [autonomni] => 0 ) ) [14431] => stdClass Object ( [nazev] => Jitka Moravcová - Publications [seo_title] => Jitka Moravcová - Publications [seo_desc] => [autor] => [autor_email] => [obsah] =>
- Čopíková J., Wimmer Z., Lapčík O., Cahlíková L., Opletal L., Moravcová J., Drašar P.: Přírodní látky svíravé a trpké chuti, Chem. Listy 108, 1053-1057 (2014).
- Čopíková J., Moravcová J., Wimmer Z., Opletal L., Lapčík O., Drašar P.: Náhradní sladidla, Chem. Listy 107, 867-874 (2013).
- Jambal I., Kefurt K., Hlaváčková M., Moravcová J: Synthesis of 2-fluoro and 4-fluoro galactopyranosyl phosphonate analogues of UDP-Gal, Res. 360, 31-39 (2012).
- Wimmer Z., Opletal L., Čopíková J., Moravcová J., Abdulmanea K.S.O., Lapčík O., Drašar P.: Kovová chuť přírodních látek a jejich derivátů, Listy 106, 926-930 (2012).
- I., Kefurt K., Moravcová J.: Inhibitory galaktosyltransferas. Chem. Listy 106, 283-288 (2012).
- Kaminský J., Dvořáková H., Štursa J., Moravcová J.: Problems with a conformation assignment of aryl-substituted resorc[4]arenes, Czech. Chem. Commun., 76, 1199-1222 (2011).
- Opletal L., Wimmer Z., Čopíková J., Lapčík O., Moravcová J., Cahlíková L., Drašar P.: Slaná chuť přírodních látek a jejich derivátů, Listy 105, 761-765 (2011).
- Čopíková J., Moravcová J., Lapčík O., Opletal L., Drašar P.: Přírodní látky chuti chladivé a jejich deriváty, Listy 105, 933-942 (2011).
- Lapčík O., Opletal L., Moravcová J., Čopíková J., Drašar P.: Přírodní látky a jejich deriváty chuti pálivé, Listy 105, 452-457 (2011).
- Kaplánek R., Polák R., Paleta O., Kefurt K., Moravcová J., Křenová I., Kodíček M.: Perfluoroalkylated derivatives of 6-deoxy-6-ethylamino-D-galactose, 1-deoxy-1-methylamino-D-glucitol, and 1-amino-1-deoxy-D-glucitol: syntheses, hemocompatibility, and effect on perfluorocarbon emulsion, Res. 345 (8), 1008-1014 (2010).
- Jurček O., Wimmer Z., Bennetová B., Moravcová J., Drašar P., Šaman D.: Novel Juvenogens (Insect Hormonogenic Agents): Preparation and Biological Tests on Neobellieria bullata, Agric. Food Chem. 57 (22), 10852-10858 (2009).
- Šimák O., Staněk J., Moravcová J.: A stereocontrolled synthesis of 3-acetamido-1,3,5-trideoxy-and 1,3,5,6-tetradeoxy-1,5-imino-d-glucitol, Res., 344, 966-971 (2009).
- Bubník Z., Čurda L., Kadlec P., Moravcová J., Melzoch K., Šárka E., Šmidrkal J., Půlkrábek J., Chochola J.: Zaměření výzkumu pro využití sacharosy k nepotravinářským účelům v ČR. Listy cukrovarnické a řepařské 125, 28-33- (2009).
- Hampl F., Moravcová J., Čopíková J., Opletal L., Lapčík O., Drašar P.: Krása a rozmanitost struktur přírodních antibiotik, Listy 103, 15 – 27 (2009).
- Moravcová J.: Vliv fytoestrogenů na symptomy menopausy a rakovinu prsu, Interní Med. 11(10), 517-519 (2008).
- Štěpánek P., Dukh M., Šaman D., Moravcová J., Kniežo L., Monti D., Venanzi M., Mancini G., Drašar P.: Synthesis and solvent driven self-aggregation studies of meso-"C-glycoside"-porphyrin derivatives, & Biomol. Chem., 5(6), 960-970 (2007).
- Klein P., Moravcová J., Kleinová T., Volek Z., Skřivanová V.: Assessment of intestinal permeability in preruminant calves by lactulose/mannitol test, Anim. Feed Sci., 16, 43-52 (2007).
- Moravcová J., Opletal L., Lapčík O., Čopíková J., Uher M., Drašar P.: Látky ovlivňující vnímání organoleptických vlastností, Listy 101, 1002 – 1010 (2007).
- Lapčík O., Čopíková J., Uher M., Moravcová J., Drašar P.: Necukerné přírodní látky chuti sladké,Listy 101, 44−54 (2007).
- Opletal L., Čopíková J., Uher M., Lapčík O., Moravcová J., Drašar P.: Přírodní látky hořké chuti, Listy 101, 895−906 (2007).
- Heissigerová H., Kočalka P., Hlaváčková M., Imberty A., Breton C., Chazalet V., Moravcová J.: Synthesis of d-galactopyranosylphosphonic and (d-galactopyranosylmethyl)phosphonic acids as intermediates of inhibitors of galactosyltransferases, Czech. Chem. Commun., 71, 1659-1672 (2006).
- Šaman D., Kratina P., Moravcová J., Wimmerová M., Wimmer Z.: Synthesis and structure assignment of 2-(4-methoxybenzyl)cyclohexyl-b-d-glucopyranoside enantiomers, Czech. Chem. Commun., 71, 1470-1483 (2006).
- Dvořáková H., Štursa J., Čajan M., Moravcová J.: Synthesis and Conformational Properties of Partially Alkylated Methylene-Bridged Resorc[4]arenes – Study of the “Flip-Flop” Inversion, J. Org. Chem., 2006, 4519 – 4527.
- Lojková L., Klejdus B., Moravcová J., Kubáň V.: Supercritical fluid extraction (SFE) of 4(5)-methylimidazole (4-MeI) and 2-acetyl-4(5)-(1,2,3,4)-tetrahydroxybutyl-imidazole (THI) from ground-coffee with high-performance liquid chromatographic-electrospray mass spectrometric quantification (HPLC/ESI-MS), Food Additives Contam. 23 (10), 963-973 (2006).
- Klejdus B., Moravcová J., Lojková L., Vacek J., Kubáň V.: Solid-phase extraction of 4(5)-methylimidazole (4Mel) and 2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)-imidazole(THI) from foods and beverages with subsequent liquid chromatographic-electrospray mass spectrometric quantification, Sep. Sci. 29 (3), 378-384 (2006).
- Čopíková J., Lapčík O., Uher M., Moravcová J., Drašar P.: Cukerná nesacharosová sladidla a příbuzné látky, Listy 100, 778 – 783 (2006).
- Popelová A., Kefurt K., Hlaváčková M., Moravcová J.: A concise synthesis of 4-nitrophenyl 2-azido-2-deoxy and 2-acetamido-2-deoxy-d-mannopyranosides, Res., 340, 161-166 (2005).
- Klejdus B., Lojková L., Lapčík O., Koblovská R., Moravcová J., Kubáň V.: Supercritical fluid extraction of isoflavones from biological samples with ultra-fast high-performance liquid chromatography/mass spectrometry, Sep. Sci., 28, 1334-1346 (2005).
- Gros L., Zeller W., Moravcová J.: Evropský prostor pro vzdělávání v chemii, Listy 99(1), 63 (2005).
- Čopíková J., Uher M., Lapčík O., Moravcová J., Drašar P.: Přírodní barevné látky, Listy 99 (11), 802-16 (2005).
- Lapčík O., Klejdus B., Davidová M., Kokoška L., Kubáň V., Moravcová J.: Isoflavonoids in the Rutaceae family: 1. Fortunella obovata, Murraya paniculata and four Citrus Phytochem. Anal., 15, 293-299 (2004).
- Moravcová J., Kleinová T., Loučka R., Tyrolová I., Kvasnička F., Dušek M., Čeřovský M., Matucha P.: The Coumestrol Content in Alfalfa Following Ensilage, Feed Sci. Technol. 115, 159-167 (2004).
- Dušek M., Kvasnička F., Moravcová J.: Stanovení organických kyselin v silážích kapilární isotachoforesou a kapilární elektroforesou, Listy 98, 418-422 (2004).
- Stursa J., Dvorakova H., Smidrkal J., Petrickova H., Moravcova J.: A novel synthesis of parent resorc[4]arene and its partial alkyl ethers, Tetrahedron Lett., 45, 2043-2046 (2004).
- Církva V., Polák R., Paleta O., Kefurt K., Moravcová J., Kodíček M., Forman S.: Novel perfluoroalkytated derivatives of d-galactopyranose and xylitol for biomedical uses. Hemocompatibility and effect on perfluorocarbon emulsions. Res. 339, 2177-2185 (2004).
- Oščendová M., Moravcová J.: Kinetics of methylation of methyl 5-deoxy-a/b-d-xylofuranosides.Czech. Chem. Commun., 69, 1877-1888 (2004).
- Drašar P., Moravcová J.: Recent advances in analysis of Chinese medical plants and traditional medicines, Chromatogr. B, 812, 3-21(2004).
- Klejdus B., Moravcová J., Kubáň V.: Reversed-phase high-performance liquid chromatographic/mass spectrometric method for separation of 4-methylimidazole and 2-acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole at pg levels, Chim. Acta, 477, 49 – 58 (2003).
- Moravcová J., Kleinová T., Loučka R., Tyrolová I., Kvasnička F., Dušek M., Čeřovský M.: Effect of Additives on Coumestrol Content in Laboratory Alfalfa Silages, J. Anim. Sci., 48, 425-431 (2003).
- Heissigerová H., Breton C., Moravcová J., Imberty A.: Molecular modeling of glycosyltransferases involved in the biosynthesis of blood group A, blood group B, Forssman, and iGb3 antigens and their interaction with substrates, Glycobiology 13(5), 377 – 386 (2003).
- Lapčík O., Štursa J., Kleinová T., Vítková M., Dvořáková H., Moravcová J., Klejdus B.: Synthesis of hapten and conjugates of coumestrol and development of immunoassay, Steroids 68, 1147-1155 (2003).
- Moravcová J., Heissigerová H., Kočalka P., Imberty A., Sýkora D., Fris M.: A novel seven-membered carbohydrate phostone, Tetrahedron Lett. 44, 8797 – 8800 (2003).
- Moravcová J., Kleinová T., Loučka R.: The Determination of Coumestrol in Alfalfa (Medicago sativa), Plant Prod., 48, 224-229 (2002).
- Moravcová J., Kleinová T.: Fytoestrogeny ve výživě – přinášejí užitek nebo riziko? Listy 96 (5), 282-289 (2002).
- Breton C., Heissigerová H., Jeanneau C., Moravcová J., Imberty A.: Comparative aspects of glycosyltransferases, Soc. Symp., 69, 23-32 (2002).
- Kefurt K., Moravcová J., Bambasová Š., Buchalová K., Vymětalíková B., Kefurtová Z., Staněk J., Paleta O.: Alkylation of Partially Protected Xylofuranoses and Tetritols with (2,2,3,3,4,4,5,5,6,6,7,7,7-Tridecafluoroheptyl)oxirane and the Stability of Protecting Acetal Groups Towards Lewis Acid-Type Catalyst, Czech. Chem. Commun., 66, 1665-1681 (2001).
- Vänttinen K., Moravcová J.: Transdermal absorption of phytoestrogens, Pharmazie 56, 711-717 (2001).
- Moravcová J.: Sacharosa jako chemická surovina, Listy 95 (4), 202-211 (2001). – článek získal cenu K. Preise za nejlepší článek uveřejněný v Chemických listech v roce 2001.
- Moravcová J., Kefurt K., Hladůvková R., Staněk J.: Pig-liver Esterase Catalyzed Hydrolysis of Methyl Tri-O-acetyl-b-D-arabinopyranoside, Methyl Tri-O-acetyl-b-D-ribopyranoside and Methyl Tri-O-acetyl-b-D-ribofuranoside, Czech. Chem. Commun., 65 (10), 1619 – 1629 (2000).
- Moravcová J., Špilová L., Čapková J., Chery F., Rollin P.: Mitsunobu Transformations of 1,2-O-Isopropylidene-a-D-pentofuranoses Mediated by Zinc Salts, Czech. Chem. Commun., 65, 1745-1753 (2000).
- Loučka R., Machačová E., Moravcová J., Čeřovský M., Voldřich M.: Vliv komplexu celulázy, hemicelulázy a glukózaoxidázy v probioticko-enzymatickém aditivu na fermentaci vojtěšky, J. Anim. Sci., 44, 87 – 92 (1999).
- Gueyrard D., Lorin C., Moravcová J., Rollin P.: A New Intramolecular Migration in Thiosugar Chemistry: S®O Transfer of a Benzthiazol-2-yl Group in Saccharidic Sulfones, Carbohydr. Chem., 18, 317 - 331 (1999).
- Moravcová J., Hamerník I., Funková G., Kefurt K., PLE Catalyzed Hydrolysis of Methyl 2,3-O-di-acetyl-5-deoxy-a- and b-D-arabinofuranosides, Carbohydr. Chem., 17, 1191-1202 (1998).
- Havlíčková H., Moravcová J.: Sugar Metabolism of Winter Wheat Cultivars Stressed with Ceral Aphids, Prod., 44, 81 - 87 (1998).
- Moravcová J., Čapková J., Staněk J. jr., Raich I.: Methyl 5-Deoxy-a- and b-D-xylofuranosides,Carbohydr. Chem., 16, 1061 - 1073 (1997).
- Moravcová J., Vanclová Z., Čapková J., Kefurt K., Staněk J. jr.: Enzymic Hydrolysis of Methyl 2,3-Di-O-acetyl-5-deoxy-a- and b-D-xylofuranosides and Active-site Model of Pig Liver Esterase,Carbohydr. Chem., 16, 1011 - 1028 (1997).
- Moravcová J., Rollin P., Lorin Ch., Gardon V., Čapková J., Mazáč J.: Regioselective Mitsunobu Thiofunctionalization of Pentofuranoses, Carbohydr. Chem., 16, 113 - 127 (1997).
- Moravcová J., Staněk J. jr., Čapková J., Loučka R.: Stanovení sacharosy, glukosy a fruktosy v rostlinách kapalinovou chromatografií na silně kyselém iontoměniči, Výroba 43, 287 - 292 (1997).
- Moravcová J., Čeřovský M., Loučka R., Voldřich M., Opatová H., Machačová E.: Vliv glukosooxidasy na obsah sacharosy, glukosy a fruktosy při silážování trávy jílkového typu a vojtěšky, Živočiš. Výroba 42, 223 - 228 (1997).
- Čeřovský M., Loučka R., Machačova E., Voldřich M., Opatová H., Moravcová J.: Vliv probioticko-enzymových preparátů na silážovatelnost trávy (Lolium multiflorum) a vojtěšky (Medicago sativa), Živočiš. Výroba 42, 323 - 329 (1997).
- Moravcová J., Čapková J., Staněk J. jr.: One-pot Synthesis of 1,2-O-isopropylidene-a-D-xylofuranose, Res., 263, 61 – 66 (1994).
- Juříček M., Grúz P., Velemínský J., Staněk J. jr., Kefurt K., Moravcová J., Jarý J.: Mutagenic Activity of 6-Azidodeoxyhexoses and Azidoalcohols in Salmonella Typhimurium and its Inhibition by a Structure-similar Carbon Source in the Medium, Res., 251, 13 – 20 (1991).
- Moravcová J.: Metody stanovení 4-methylimidazolu v kuléru, Vědy, 9, 307 (1991).
- Gonzales G., Pérez M., Santana I., Marcet M., Staněk J. jr., Moravcová J., Jarý J.: Mutagenic Activity of 3-Azido-1,2-propanediol and Sodium Azide Applied to Sugar Cane Callus Cells, Biologia Plantarum, 32, 388 – 390 (1990).
- Juříček M., Grúz P., Velemínský J., Staněk J. jr., Moravcová J., Jarý J.: High Mutagenic Activity of 3-Azido-1,2-propandiol (azidoglycerol, AG) in strain D7 of Saccharomyces Cerevisiae, Res., 178, 43 – 47 (1987).
- Juříček M., Velemínský J., Jefremová G. J., Kočišová J., Gichner T., Staněk J. jr., Moravcová J., Jarý J.: Comparative Mutagenicity of 3-Azido-1,2-propanediol and Sodium Azide in Various Pro- and Eukaryote Systems, Res., 179, 175–182 (1987).
- Čapek K., Vodrážková-Medonosová M., Moravcová J., Sedmera P.: Partially Acetylated Sucrose. Structures of Hepta-O-acetylsucroses Formed by Deacetylation of Octa-O-acetylsucrose, Czechoslov. Chem. Commun., 51, 1476 – 1486 (1986).
- Staněk J. jr., Moravcová J., Jarý J.: Crystalline Methyl-b-L-rhamnofuranoside in Fischer Glycosidation of L-Rhamnose, Carbohydr. Chem., 4, 79 – 90 (1985).
- Moravcová J., Večeřa M.: Kinetics and Mechanism of Hydrolysis of Substituted Phenyl N-(4-methylfenyl)sulfonylcarbamates. Solvolysis of 3-Nitrofenyl N-(4-methylfenyl)sulfonylcarbamate in Mixtures Water-1,4-Dioxane and Water-tert.butylalcohol and its Decomposition to Neutral Molecules in Non-aqueous Media, Czechoslov. Chem. Commun., 44, 2639- 2651 (1979).
- Moravcová J., Večeřa M.: Kinetics and Mechanism of Hydrolysis of Aryl N-trichloroacetylcarbamates, Czechoslov. Chem. Commun., 42, 3048 – 3056 (1977).
[iduzel] => 14431 [canonical_url] => //uchpl.vscht.cz/contact/staff/JitkaMoravcova/jitkamoravcova-publications [skupina_www] => Array ( ) [url] => /contact/staff/JitkaMoravcova/jitkamoravcova-publications [sablona] => stdClass Object ( [class] => stranka [html] => [css] => [js] => [autonomni] => 1 ) ) ) [iduzel] => 14428 [canonical_url] => //uchpl.vscht.cz/contact/staff/JitkaMoravcova [skupina_www] => Array ( ) [url] => /contact/staff/JitkaMoravcova [sablona] => stdClass Object ( [class] => stranka [html] => [css] => [js] => [autonomni] => 1 ) ) [13933] => stdClass Object ( [nazev] => Ondřej Šimák [seo_title] => Ondřej Šimák [seo_desc] => Ondřej Šimák Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology UCT Prague University of Chemistry and Technology Prague [autor] => [autor_email] => [obsah] =>
WORK EXPERIENCE
|
|
|
since 2014 |
ICT Prague (now UCT Prague), Faculty of Food and Biochemical Technology, Department of Chemistry of Natural Compounds, Assistant Professor |
|
since 2014 |
IOCB AV ČR, junior scientist in Ing. Ivan Rosenberg, CSc. team |
|
2009 - 2013 |
IOCB AV ČR, postdoctor fellow in Ing. Ivan Rosenberg, CSc. team |
|
2007 - 2008 |
UCT Prague, Faculty of Food and Biochemical Technology, Department of Chemistry of Natural Compounds, staff scientist |
|
2006 - 2007 |
Charles University, First Faculty of Medicine, staff scientist |
|
2004 - 2005 |
UCT Prague, Faculty of Food and Biochemical Technology, Department of Chemistry of Natural Compounds, staff scientist |
EDUCATION |
|
|
2001 – 2009 |
PhD study - UCT Prague, Faculty of Food and Biochemical Technology, Department of Chemistry of Natural Compounds |
|
1996 - 2001 |
Msc. study - UCT Prague, Faculty of Food and Biochemical Technology, Department of Chemistry of Natural Compounds |
TRAINING |
|
|
2008 |
Universita Tor Vergata Roma, Italy - research fellowship oriented on physical property of substituted porphyrins |
|
1999 |
UCT Prague, Faculty of Food and Biochemical Technology, Department of Chemistry of Natural Compounds- pomocná vědecká síla |
TEACHING |
|
|
since 2014 |
Chemistry of Saccharides and biopolymers at UCT Prague |
Panova N., Zborníková E., Šimák O., Pohl R., Kolář M., Bogdanová K., Večeřová R., Seydlová G., Fišer R., Hadravová R., Šanderová H., Vítovská D., Šiková M., Látal T., Lovecká P., Barvík I., Krásný L., Rejman D.: Insights into the Mechanism of Action of Bactericidal Lipophosphonoxins. PLoS ONE 2015, 10(12): e0145918. Link
Pachl P., Šimák O., Řezáčová P., Fábry M., Buděšínský M., Rosenberg I., Brynda J.: Structure-based design of a bisphosphonate 5'(3')-deoxyribonucleotidase inhibitor. MedChemComm 2015, 6, 1635-1638. Link
Petrová M., Páv O., Buděšínský M., Zborníková E., Novák P., Rosenbergová Š., Pačes O., Liboska R., Dvořáková I., Šimák O., Rosenberg I.: Straightforward Synthesis of Purine 4′-Alkoxy-2′-deoxynucleosides: First Report of Mixed Purine−Pyrimidine 4′-Alkoxyoligodeoxynucleotides as New RNA Mimics. Org. Lett. 2015, 17, 3426-3429. Link
Šimák O., Pachl P., Fábry M., Buděšínský M., Jandušík T., Hnízda A., Skleničková R., Petrová M., Veverka V., Řezáčová P., Brynda J., Rosenberg I.: Conformationally constrained nucleoside phosphonic acids – potent inhibitors of human mitochondrial and cytosolic 5′(3′)-nucleotidases Org. Biomol. Chem. 2014, 12, 7971-7982. Link
Šípová H., Špringer T., Rejman D., Šimák O., Petrová M., Novák P., Rosenbergová Š., Páv O., Liboska R., Barvík I., Štěpánek J., Rosenberg I., Homola, J.: 5’-O-Methylphosphonate nucleic acids – new modified DNAs that increase the E. coli RNase H cleavage rate of hybrid duplexes. Nucleic Acids Research, 2014, 42, 5378-89. Link
Šimák O., Košiová I., Panova N., Buděšínský M., Petrová M., Rejman D., Liboska R., Páv O., Rosenberg I.: Inhibition of Human Thymidine Phosphorylase by Conformationally Constrained Pyrimidine Nucleoside Phosphonic Acids and their “Open-Structure” Isosteres. European Journal of Medicinal Chemistry 2014, 74, 145-168. Link
Pachl P., Fábry M., Rosenberg I., Šimák O., Řezáčová P., Brynda J.: Structures of human cytosolic and mitochondrial nucleotidases: implications for structure-based design of selective inhibitors. Acta Crystallographica Section D, 2014, 70, 461-470. Link
Zelenka K.; Trnka T., Tislerova I., Monti D., Cinti S., Naitana M.L., Schiaffino L., Vananzi M., Laguzzi G., Luvidi L., Mancini G., Nováková Z., Šimák O., Wimmer Z., Drašar P.: Spectroscopic, Morphological, and Mechanistic Investigation of the Solvent-Promoted Aggregation of Porphyrins Modified in meso-Positions by Glucosylated Steroids. Chem.-Eur. J. 2011, 17, 13743-13753. Link
Štěpánek P., Šimák O., Nováková Z., Wimmer Z., Drašar P.: Asymmetrically substituted calix[4]pyrrole with chiral substituents. Org. Biomol. Chem. 2011, 9, 682-683. Link
Pressová M., Buděšínský M., Košiová I., Kopecký V., Cvačka J., Kašička V., Šimák O., Točík Z., Rosenberg I.: Oligomerization of Adenosin-5 '-O-ylmethylphosphonate, an Isopolar AMP Analogue: Evaluation of the Route to Short Oligoadenylates. Biopolymers 2010, 93, 277-289. Link
Košiová I., Točík Z., Buděšínský M., Šimák O., Liboska R., Rejman D., Pačes O., Rosenberg I.: Methyl 4-toluenesulfonyloxymethylphosphonate, a new and versatile reagent for the convenient synthesis of phosphonate-containing compounds. Tetrahedron Lett. 2009, 50, 6745-6747. Link
Šimák O., Staněk J., Moravcová J.: A stereocontrolled synthesis of 3-acetamido-1,3,5-trideoxy- and 1,3,5,6-tetradeoxy-1,5-imino-D-glucitol. Carbohydr. Res. 2009, 344, 966-971. Link
[iduzel] => 6875 [canonical_url] => //uchpl.vscht.cz/kontakt/zamestnaci/6872/6875 [skupina_www] => Array ( ) [url] => /contact/staff/ondrejsimak/6875 [sablona] => stdClass Object ( [class] => stranka [html] => [css] => [js] => [autonomni] => 1 ) ) ) [iduzel] => 13933 [canonical_url] => //uchpl.vscht.cz/contact/staff/ondrejsimak [skupina_www] => Array ( ) [url] => /contact/staff/ondrejsimak [sablona] => stdClass Object ( [class] => stranka [html] => [css] => [js] => [autonomni] => 1 ) ) [13171] => stdClass Object ( [nazev] => Kamil Parkan [seo_title] => Kamil Parkan [seo_desc] => Kamil Parkan Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology UCT Prague University of Chemistry and Technology Prague [autor] => [autor_email] => [obsah] =>
| Researcher ID: F-1138-2017, ORCID ID: 0000-0001-7585-6004 | |
Education |
|
|
2000-2005 |
MSc. study |
|
Institute of Chemical Technology, Prague (now UCT Prague) |
|
|
Department of Chemistry of Natural Compounds |
|
|
MSc. thesis: Synthesis of polyhydroxylated chiral aldehydes as reactants of aldol reaction |
|
|
Supervisor: Doc. Ing. Ladislav Kniežo, CSc. |
|
|
2005-2010 |
PhD study |
|
University of Chemistry and Technology, Prague |
|
|
Department of Chemistry of Natural Compounds |
|
|
PhD thesis: Stereoselective synthesis of disaccharides analogues |
|
|
Supervisor: Doc. Ing. Ladislav Kniežo, CSc. |
|
|
2010-2012 |
Postdoctoral fellowship |
|
Institute of Organic Chemistry and Biochemistry AS CR, Prague |
|
|
Supervisors: Doc. RNDr. Jan Konvalinka, CSc. a prof. RNDr. Martin Kotora, CSc. |
|
|
2021
|
habilitation in the field Organic Chemistry |
|
University of Chemistry and Technology, Prague |
|
|
Habilitation thesis title: Syntéza C-glykosidů a C-disacharidů
|
|
Work position |
|
|
2012 - 2021 |
Department of Chemistry of Natural Compounds, UCT Prague, Assistent professor |
|
2022 -now |
Associate Professor at the Department of Chemistry of Natural Compounds, UCT Prague |
Teaching |
|
|
|
Stereoselective synthesis |
|
|
Structure and reactivity |
|
Bioorganic Chemistry of Natural Compounds
|
|
|
Bioorganic Chemistry of Carbohydrates and nucleic acids |
|
|
Chemistry of Natural Compounds: Semestral Work |
|
Fellowships |
|
|
2004 |
ERASMUS Fellowship |
|
Chimie des hétérocycles et glucides, Blaise Pascal University, Clermont-Ferrand, Francie |
|
|
Supervisor: Prof. Yves Troin |
|
|
2008 |
PhD Fellowship |
|
Department of Chemistry and Biochemistry, University of Colorado, Boulder, USA |
|
|
Supervisor: Prof. Josef Michl |
|
|
2010-2012 |
Postdoctoral fellowship |
|
Institute of Organic Chemistry and Biochemistry AS CR, Prague |
|
|
Supervisors: Doc. RNDr. Jan Konvalinka, CSc. a prof. RNDr. Martin Kotora, CSc. |
|
Grants and Projects |
|
|
2022-2024 |
15N isotopic labeling in NMR structural analysis of N-disaccharides |
|
GAČR, No. 22-17586S; member or research team |
|
|
2018-2022
|
Recombinant Biotechnology and Immunotherapy Centre |
|
Centre, OP - EU Operational Program No. 16_025/0007397_01; member of the research team |
|
|
2017-2021
|
Enzymatically stable galectin inhibitors |
|
Gilead Sciences Research Center; co-PI |
|
|
2015-2017 |
Calix[4]arene/C-oligosaccharide glycocluster design for improved selectivity of interactions with lectins |
|
GACR No. 15-17572S; member of the research team |
|
|
2012-2014 |
New Pd-catalyzed modular approach to non-hydrolysable vectors for transfection systems |
|
GACR, No. P207/12/P713, PI |
|
|
2005-2010 |
Ministry of education youth and sports, No. 6046137305. |
|
2010-2011 |
HIV ACE (Targeting assembly of infectious HIV particles), FP7-HEALTH |
|
project ref. 201095; member of the research team |
|
|
2008-2010 |
Stereoselective synthesis of disaccharide analogues |
|
GACR, No. 203/08/1124; member of the research team |
|
[urlnadstranka] => [ogobrazek] => [pozadi] => [poduzel] => stdClass Object ( [62510] => stdClass Object ( [nazev] => Graduates [seo_title] => Graduates [seo_desc] => [autor] => [autor_email] => [obsah] =>
| Řepková Kristýna (2014) | Kratochvíl Michal, (2019) |
| Erhartová Lenka (2015) |
Marková Barbora, Bc. (2019) |
|
Choutka Jan (2015) |
Rahm Michal (2019) |
| Nováková Karla (2016) | Vršanová Lucie (2019) |
| Beáta Oroszová (Ph.D., 2017) |
Vaňková Karolína (2020) |
| Housková Kateřina (2018) |
Battaglia Caren (Master Double Degree, 2020) |
| Prouza Vít, (2018) |
|
| Tóthová Lucia, (2018) |
| Řepková Kristýna, Bc. | Synthesis of new analogues of neamine by using of Pd-catalyzed reaction | 2014 |
| Erhartová Lenka, Bc. | Preparation of new glycoclusters presenting D-gluco- and D-galactopyranose on calix[4]arene and porphyrine cores by using Pd-catalyzed reaction | 2015 |
| Choutka Jan, Bc. | The synthesis of C-disaccharides by using Suzuki-Miyaura reaction | 2015 |
| Nováková Karla, Bc. | New synthetic approach for the synthesis of C-glycosides and C-disaccharides | 2016 |
| Housková Kateřina, Bc. |
Synthesis of C-disaccharides and biological activity studies with galectins | 2018 |
| Prouza Vít, Bc. | S-glycosides: Modular synthesis and biological activity studies | 2018 |
| Tóthová Lucia, Bc. |
Saccharides biosensors for detection of bacterial contamination of drinking water | 2018 |
| Kratochvíl Michal, Bc. | Synthesis and use of 2-oxyglycals | 2019 |
| Marková Barbora, Bc. | Preparation of new glycoclusters by using Pd-catalyzed reaction | 2019 |
| Rahm Michal, Bc. |
Ir-catalyzed C-H silylation of glycals |
2019 |
| Vršanová Lucie, Bc. | Synthesis of C- and S-glycosides derived from GalNAc | 2019 |
| Vaňková Karolína, Bc. | Use of Hiyama reaction for the synthesis of aryl C-glycosides | 2020 |
|
Battaglia Caren Bc. (Master Double Degree) |
Synthesis of glycomimetics for fluorescence polarization assay with galectins | 2020 |
| Mgr. Beáta Oroszová, Ph.D.; | Novel C-disaccharides for the construction of ligands inhibiting interactions between pathogen and cell. | 2017 |
[urlnadstranka] => [ogobrazek] => [pozadi] => [iduzel] => 62506 [canonical_url] => [skupina_www] => Array ( ) [url] => /contact/staff/kamilparkan/ph-d-thesis [sablona] => stdClass Object ( [class] => stranka [html] => [css] => [js] => [autonomni] => 1 ) ) [62504] => stdClass Object ( [nazev] => People [seo_title] => People [seo_desc] => [autor] => [autor_email] => [obsah] =>
Employees:
- doc. Ing. Kamil Parkan, Ph.D
- Martina Wimmerová
Ph.D. students:
- Ing. Michal Kratochvíl
- Ing. Jakub Zýka
- Ing. Vít Prouza
- Ing. Jan Choutka
Students:
- Bc. Nikola Kopalová
- Bc. Petra Gwozdiaková
- Bc. Karel Tůma
- Bc. Věra Šemelíková
- Martin Jánský
- Klaudia Hladoníková
- Adam Rybka
- Michal Fischer
- Ondřej Orság
Master Thesis Ph.D. Thesis
2022
Kratochvíl, M.; Cisarová, I.; Pohl, R. ; Kaminský, J; Parkan, K.: Silicon-bridged (1 -> 1)-disaccharides: an umpoled glycomimetic scaffold. Org. Biomol. Chem. 2022, 20, 7613-7621. Online
; Kaminský, J.; Pohl, R.; Miyazaki, T.: Unlocking the Hydrolytic Mechanism of GH92 alpha-1,2-Mannosidases: Computation Inspires the use of C-Glycosides as Michaelis Complex Mimics. Chem.-Eur. J. 2022, 28, e202200148. Online
2021
22. Vaňková, K.; Rahm, M.; Choutka, J.; Pohl, R.; Parkan, K.: Facile Approach to C-glucosides by Using a Protecting-Group-Free Hiyama Cross-Coupling Reaction: High-Yielding Dapagliflozin Synthesis. Chem.-Eur. J., 2021, 27, 10583– 10588. VIP Online
21. Vaňková, K., Šimák, O., Kettelhoit, K., Parkan, K.: One Step Transformation of Glycals into 1-Iodo Glycals. In Carbohydrate Chemistry: Proven Synthetic Methods, Vol 5. Kosma P., Wrodnigg T. M., Stutz A., CRC Press, Taylor & Francis Group:Boca Raton, 2021, Vol. 5, pp 11-16. DOI: 10.1201/9781351256087, ISBN 9780815367888. Online
2020
20. Choutka, J.; Kratochvíl, M.; Zýka, J.; Pohl, R.; Parkan K. Straightforward synthesis of protected 2-hydroxyglycals by chlorination-dehydrochlorination of carbohydrate hemiacetals. Carbohydr. Res. 2020, 496, 108086. Online
2019
19. Faltinek, L.; Fujdiarová, E.; Melicher, F.; Houser, J.; Kašáková, M.; Kondakov, N.; Kononov, L.; Parkan, K.; Vidal, S.; Wimmerová, M. Lectin PLL3, a Novel Monomeric Member of the Seven-Bladed β-Propeller Lectin Family. Molecules 2019, 24, 4540. Online
18. Jančaříková, G.; Houser, J.; Kašáková, M.; Oroszová, B.; Bertolotti, B.; Parkan, K.; Moravcová, J.; Wimmerová, M. Fucosylated inhibitors of recently identified bangle lectin from Photorhabdus asymbiotica. Sci. Rep. 2019, 9, 14904. Online
2018
17. Choutka, J., Pohl, R., Parkan, K.: MOP and EE Protecting Groups in Synthesis of α- or β-Aryl-C-Glycosides from Glycals. ACS Omega 2018, 3, 7875-7887. Online
2017
16. Raich, I.; Lövyová, Z.; Trnka, L.; Parkan, K.; Kessler, J.; Pohl, R.; Kaminský, J. Limitations in the description of conformational preferences of C-disaccharides: The (1 → 3)-C-mannobiose case. Carbohydr. Res. 2017, 451, 42-50. Online
15. olyvalent C-glycomimetics based on L-fucose or D-mannose as potent DC-SIGN antagonists. Org. Biomol. Chem. 2017, 15, 3995-4004. Online
2016
14. Bertolotti, B.; Oroszová, B.; Sutkeviciute, I.; Kniežo, L.; Fieschi, F.; Parkan, K.; Lovyová, Z.; Kašáková, M.; Moravcová, J. Nonhydrolyzable C-disaccharides, a new class of DC-SIGN ligands. Carbohydr. Res. 2016, 435, 7-18. Online
13. Kožíšek, M.; Štěpánek, O.; Parkan, K.; Albiñana, B. C.; Pávová, M.; Weber, J.;a, Hans-Georg Krӓusslich, H.-G.; Konvalinka, J.; Machara, A. Synthesis and evaluation of 2-pyridinylpyrimidines as inhibitors of HIV-1 structural protein assembly. Bioorg. Med. Chem. Lett. 2016, 26 , 3487–3490. Online
12. Machara, A.; Lux, V.; Kožíšek, M.; Grantz, Šašková, K.; Štěpánek, O.; Kotora, M.; Parkan, K.; Pávová, M.; Glass, B.; Sehr, P.; Lewis, J.; Mueller, B.; Kraeusslich, H.-G.; Konvalinka J.; Specific inhibitors of HIV capsid assembly binding to the C-terminal domain of the capsid protein: evaluation of 2-arylquinazolines as potential virostatics. J. Med. Chem. 2016, 59, 545-558. Online
2015
11. Šnajdr, I.; Parkan, K.; Hessler, F.; Kotora M. Cross-metathesis Reaction of α- and β-Vinyl C-glycosides with Alkenes. Beilstein J. Org. Chem. 2015, 11, 1392–1397. Online
10. Oroszová, B.; Choutka, J.; Pohl, R.; Parkan, K. Modular Stereoselective Synthesis of (1→2)-C-Glycosides based on the sp2–sp3 Suzuki–Miyaura Reaction. Chem. Eur. J. 2015, 21, 7043-7047. Online
2014
9. Kraeusslich, H.; Sticht, J.; Wildova M.; Lux, V.; Konvalinka J.; Kotora, M.; Grantz, Saskova, K.; Kozisek, M.; Stepanek, O.; Parkan, K.; Machara, A. Use of substituted fused heterocyclic compounds for inhibiting HIV capsid assembly to treat HIV. WO 2014128206-A1, Aug 28, 2014. Online
8. Kraeusslich, H.; Sticht, J.; Wildova M.; Lux, V.; Konvalinka J.; Kotora, M.; Grantz, Saskova, K.; Kozisek, M.; Stepanek, O.; Parkan, K.; Machara, A. 2,4-Substituted or 4,6-substituted pyrimidine compound useful for inhibiting HIV capsid assembly for treating a patient suffering from HIV. WO 2014128213-A1, Aug 28, 2014. Online
7. Kraeusslich, H.; Sticht, J.; Wildova M.; Lux, V.; Konvalinka J.; Kotora, M.; Grantz, Saskova, K.; Kozisek, M.; Stepanek, O.; Parkan, K.; Machara, A. 2,4-Substituted or 4,6-substituted pyrimidine compound useful for inhibiting HIV capsid assembly for treating a patient suffering from HIV. EP 2769722-A1, Aug 27, 2014. Online
6. Kraeusslich, H.; Sticht, J.; Wildova M.; Lux, V.; Konvalinka J.; Kotora, M.; Grantz, Saskova, K.; Kozisek, M.; Stepanek, O.; Parkan, K.; Machara, A. Use of substituted fused heterocyclic compounds for inhibiting HIV capsid assembly to treat HIV. EP 2769723-A1, Aug 27, 2014. Online
5. Parkan, K.; Pohl R.; Kotora, M. Cross-Coupling Reaction of Saccharide-Based Alkenyl Boronic Acids with Aryl Halides: The Synthesis of Bergenin, Chem. Eur. J. 2014, 20, 4414 – 4419. Online
2011
4. Lovyova, Z.; Parkan, K.; Kniezo, L. Stereoselective preparation of four 3-C-mannosylated D- and L-glucals from a single starting compound, Tetrahedron 2011, 67, 4967 – 4979. Online
3. Olive, A.; Parkan, K.; Givelet, C.; Michl, J. Covalent Stabilization: A Sturdy Molecular Square from Reversible Metal-Ion-Directed Self-Assembly, J. Am. Chem. Soc. 2011, 133, 20108 – 20111. Online
2010
2. Parkan, K.; Werner, L.; Lovyova, Z.; Prchalova, E.; Kniezo, L. An approach to stereoselective preparation of 3-C-glycosylated D- and L-glucals. Carbohydr. Res. 2010, 345, 352–362. Online
2008
1. Parkan, K.; Vich, O.; Dvorakova, H.; Kniezo, L. Stereoselective preparation of 2,3-dideoxy-3-C-[(α-D-galactopyranosyl)methyl]-D-arabino-hexopyranose and 2,3-dideoxy-3-C-[(α-D-galactopyranosyl)methyl]-L-arabino-hexopyranose. Collect. Czech. Chem. Commun. 2008, 73, 690–700. Online
[urlnadstranka] => [ogobrazek] => [pozadi] => [iduzel] => 14439 [canonical_url] => [skupina_www] => Array ( ) [url] => /contact/staff/kamilparkan/Publications [sablona] => stdClass Object ( [class] => stranka [html] => [css] => [js] => [autonomni] => 1 ) ) ) [iduzel] => 13171 [canonical_url] => [skupina_www] => Array ( ) [url] => /contact/staff/kamilparkan [sablona] => stdClass Object ( [class] => stranka [html] => [css] => [js] => [autonomni] => 1 ) ) ) [sablona] => stdClass Object ( [class] => stranka [html] => [css] => [js] => [autonomni] => 1 ) [api_suffix] => )