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Technická 5
166 28 Prague 6 – Dejvice
IČO: 60461337
VAT: CZ60461373

Data mail: sp4j9ch

Copyright: UCT Prague 2015
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We offer an undergraduate bachelor degree program as well as a master degree program in the Czech language only. For information about study programs in English, please visit the university's website.

Study with us

We offer the research degree program Doctor of Philosophy (PhD) in Organic Chemistry.

Why study for a PhD at our department?

You will become a member of an internationally recognised research team providing high quality research. You will develop the skills and the knowledge needed to pursue your chosen career—in academia, at research organizations, or in public service.

How to apply?

Our prospective student portal provides details about the application process for PhD programmes at UCT Prague. 

Our past graduates

Battaglia Caren Bc. (Master Double Degree)

Abdulmanea Khaled Saleh Omar, MSc., PhD (Yemen): Flavonoids in the Apiaceae family (2012)

Irekhjargal Jambal, MSc., PhD (Mongolia): Inhibitors of galactosyltransferases (2012)

Our present students

Uladzimir Bildziukevich, MSc. (Belarus): Steroid-based compounds with potential pharmacologic importance

Jana Šusteková, Ing. (Slovakia): Self-assembly in supramolecular systems based on steroid compounds

Joint-degree doctoral programme graduates

Ing. Ondřej Jurček, PhD (Czechia): Steroid conjugates for applications in pharmacology and biology (2011), with the Faculty of Mathematics and Science, University of Jyväskylä, Finland

Ing. Helena Heissigerová, PhD (Czechia): Glycosyltransferases: Etude comparative, modelisation moleculaire et synthese de nouveaux inhibiteurs (2003), with the Université Joseph Fourier – Grenoble, France

 

9 We accept students within the framework of the IAESTE exchange programme.

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We are open to cooperation on common projects or through contracts.

We offer our partners:

  • synthesis of specialty chemicals from natural compounds and their analogs
    • steroids and other terpeniods
    • porphyrins
    • flavonoids
    • saccharides
    • glycosides, C-glycosides
    • non-isotopic labeled compounds

 

  • prepararion of antibodies, immunogens, tracers and others components of immunoassays
  • structural analysis
  • quantitative analysis
  • consultancy in the development of synhtetic methods
  • consultancy in the development of analytical methods 
  • specialty chemicals and immunochemicals from our libraries

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Scientific orientation of the department 

  • The search for new compounds with novel properties.
  • Biologically active compounds are our inspiration.

Research topics

Chemistry of steroids and other terpenoids

Prof. RNDr. Pavel Drašar, DSc., EurChem, CChem, CSci, FRSC 

Analytical and bioanalytical methods

Prof. Dr. RNDr. Oldřich Lapčík 

Diagnostic and therapeutic nanosystems

RNDr. Miroslav Ledvina, Ph.D.

Chemistry of triterpenoid supramolecules

Prof. Ing. Zdeněk Wimmer, DrSc.

Structural analysis and molecular modeling

Doc. Dr. Ing. Ivan Raich

Laboratory of forensic analysis of biologically active compounds

doc. Ing. Martin Kuchař, Ph.D.

Chemistry of Saccharides and Glycomimetics

doc. Ing. Kamil Parkan, Ph.D.

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Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, UCT Prague  

k (+420) 220 444 260

Technická 5      

W (+420) 220 444 422

166 28 Praha 6

 

 

šířka 215px

Head of Department

 

Prof. Dr. RNDr. Oldřich Lapčík

k (+420) 220 444 448

b Oldrich.Lapcik@vscht.cz

website

CV

room BS18

 ◳ Obrázek1 (jpg) → (originál)

Secretary of Department

šířka 215px

Secretary 

assoc. prof. Ing. Kamil Parkan, Ph.D.

Irena Dražilová

k (+420) 220 444 265

k (+420) 220 444 260

b Kamil.Parkan@vscht.cz

b Irena.Drazilova@vscht.cz

website

 

 CV
building A, room A246

building A, room A244

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The Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology at UCT Prague was founded in 1991 as the successor to the Laboratory of Monosaccharides. Its mission includes both education and training at the graduate as well as postgraduate level and research and development in several fields crossing the frontier between organic chemistry and biology.

Our department's research aims to understand living systems at the molecular level, providing new molecules with new properties that eventually could become medicines, among other things. It is essential to continue this research at the fundamental level so as to provide tools for designing, synthesizing, and evaluating new functional molecules for targeting applications. Nature is our inspiration.

Key research areas include:

  • Chemistry of steroids and other terpenoids
  • Chemistry of supramolecules with chiral natural compounds
  • Synthesis of ligands for the cell-cell recognition
  • The development of nanosensors for the sensing of pathogenic processes
  • Analytical and bioanalytical methods
  • Forensic analysis of biologically active compounds
  • Chemistry of saccharides and glycomimetics
  • Molecular modeling

The study of the chemical background of natural processes is a huge adventure, which we ourselves enjoy and wish to share with others. —Oldrich Lapcik, Department Chair

For further details about our research topics, please visit the webpages of individual teams.

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DATA


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    [nazev] => Ondřej Šimák
    [seo_title] => Ondřej Šimák
    [seo_desc] => Ondřej Šimák Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology UCT Prague University of Chemistry and Technology Prague 
    [autor] => 
    [autor_email] => 
    [obsah] => 

WORK EXPERIENCE

 

since 2014

ICT Prague (now UCT Prague), Faculty of Food and Biochemical Technology, Department of Chemistry of Natural Compounds, Assistant Professor

since 2014

IOCB AV ČR, junior scientist in Ing. Ivan Rosenberg, CSc. team

2009 - 2013

IOCB AV ČR, postdoctor fellow in Ing. Ivan Rosenberg, CSc. team

2007 - 2008

UCT Prague, Faculty of Food and Biochemical Technology, Department of Chemistry of Natural Compounds, staff scientist

2006 - 2007

Charles University, First Faculty of Medicine, staff scientist

2004 - 2005

UCT Prague, Faculty of Food and Biochemical Technology, Department of Chemistry of Natural Compounds, staff scientist

EDUCATION

 

2001 – 2009

PhD study - UCT Prague, Faculty of Food and Biochemical Technology, Department of Chemistry of Natural Compounds

1996 - 2001

Msc. study - UCT Prague, Faculty of Food and Biochemical Technology, Department of Chemistry of Natural Compounds

TRAINING

 

2008

Universita Tor Vergata Roma, Italy - research fellowship oriented on physical property of substituted porphyrins

1999

UCT Prague, Faculty of Food and Biochemical Technology, Department of Chemistry of Natural Compounds- pomocná vědecká síla

TEACHING

 

since 2014

Chemistry of Saccharides and biopolymers at UCT Prague

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Panova N., Zborníková E., Šimák O., Pohl R., Kolář M., Bogdanová K., Večeřová R., Seydlová G., Fišer R., Hadravová R., Šanderová H., Vítovská D., Šiková M., Látal T., Lovecká P., Barvík I., Krásný L., Rejman D.: Insights into the Mechanism of Action of Bactericidal Lipophosphonoxins. PLoS ONE 2015, 10(12): e0145918. Link

Pachl P., Šimák O., Řezáčová P., Fábry M., Buděšínský M., Rosenberg I., Brynda J.: Structure-based design of a bisphosphonate 5'(3')-deoxyribonucleotidase inhibitor. MedChemComm 2015, 6, 1635-1638. Link

Petrová M., Páv O., Buděšínský M., Zborníková E., Novák P., Rosenbergová Š., Pačes O., Liboska R., Dvořáková I., Šimák O., Rosenberg I.: Straightforward Synthesis of Purine 4′-Alkoxy-2′-deoxynucleosides: First Report of Mixed Purine−Pyrimidine 4′-Alkoxyoligodeoxynucleotides as New RNA Mimics. Org. Lett. 2015, 17, 3426-3429. Link

Šimák O., Pachl P., Fábry M., Buděšínský M., Jandušík T., Hnízda A., Skleničková R., Petrová M., Veverka V., Řezáčová P., Brynda J., Rosenberg I.: Conformationally constrained nucleoside phosphonic acids – potent inhibitors of human mitochondrial and cytosolic 5′(3′)-nucleotidases Org. Biomol. Chem. 2014, 12, 7971-7982. Link

Šípová H., Špringer T., Rejman D., Šimák O., Petrová M., Novák P., Rosenbergová Š., Páv O., Liboska R., Barvík I., Štěpánek J., Rosenberg I., Homola, J.: 5’-O-Methylphosphonate nucleic acids – new modified DNAs that increase the E. coli RNase H cleavage rate of hybrid duplexes. Nucleic Acids Research, 2014, 42, 5378-89. Link

Šimák O., Košiová I., Panova N., Buděšínský M., Petrová M., Rejman D., Liboska R., Páv O., Rosenberg I.: Inhibition of Human Thymidine Phosphorylase by Conformationally Constrained Pyrimidine Nucleoside Phosphonic Acids and their “Open-Structure” Isosteres. European Journal of Medicinal Chemistry 2014, 74, 145-168.  Link

Pachl P., Fábry M., Rosenberg I., Šimák O., Řezáčová P., Brynda J.: Structures of human cytosolic and mitochondrial nucleotidases: implications for structure-based design of selective inhibitors. Acta Crystallographica Section D, 2014, 70, 461-470. Link

Zelenka K.; Trnka T., Tislerova I., Monti D., Cinti S., Naitana M.L., Schiaffino L., Vananzi M., Laguzzi G., Luvidi L., Mancini G., Nováková Z., Šimák O., Wimmer Z., Drašar P.: Spectroscopic, Morphological, and Mechanistic Investigation of the Solvent-Promoted Aggregation of Porphyrins Modified in meso-Positions by Glucosylated Steroids. Chem.-Eur. J. 2011, 17, 13743-13753. Link

Štěpánek P., Šimák O., Nováková Z., Wimmer Z., Drašar P.: Asymmetrically substituted calix[4]pyrrole with chiral substituents. Org. Biomol. Chem. 2011, 9, 682-683. Link

Pressová M., Buděšínský M., Košiová I., Kopecký V., Cvačka J., Kašička V., Šimák O., Točík Z., Rosenberg I.: Oligomerization of Adenosin-5 '-O-ylmethylphosphonate, an Isopolar AMP Analogue: Evaluation of the Route to Short Oligoadenylates. Biopolymers 2010, 93, 277-289. Link

Košiová I., Točík Z., Buděšínský M., Šimák O., Liboska R., Rejman D., Pačes O., Rosenberg I.: Methyl 4-toluenesulfonyloxymethylphosphonate, a new and versatile reagent for the convenient synthesis of phosphonate-containing compounds. Tetrahedron Lett. 2009, 50, 6745-6747. Link

Šimák O., Staněk J., Moravcová J.: A stereocontrolled synthesis of 3-acetamido-1,3,5-trideoxy- and 1,3,5,6-tetradeoxy-1,5-imino-D-glucitol. Carbohydr. Res. 2009, 344, 966-971. Link

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UCT Prague
Technická 5
166 28 Prague 6 – Dejvice
IČO: 60461337
VAT: CZ60461373

Data mail: sp4j9ch

Copyright: UCT Prague 2015
Information provided by the Department of International Relations and the Department of R&D. Technical support by the Computing Centre.
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