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Technická 5
166 28 Prague 6 – Dejvice
IČO: 60461337
VAT: CZ60461373
Data mail: sp4j9ch
Copyright: UCT Prague 2015
Information provided by the Department of International Relations and the Department of R&D. Technical support by the Computing Centre. [paticka_odkaz_mail] => mailto:Ondrej.Simak@vscht.cz [social_fb_title] => [social_tw_title] => [social_yt_title] => [google_search] => 001523547858480163194:u-cbn29rzve [drobecky] => You are here: UCT Prague - FFBT - UCHPL [aktualizovano] => Updated [autor] => Author [paticka_mapa_alt] => [stahnout] => Download [intranet_odkaz] => http://intranet.vscht.cz/ [intranet_text] => Intranet [logo_mobile_href] => / [logo_mobile] => [mobile_over_nadpis_menu] => Menu [mobile_over_nadpis_search] => Search [mobile_over_nadpis_jazyky] => Languages [mobile_over_nadpis_login] => Login [menu_home] => Homepage [zobraz_desktop_verzi] => switch to desktop version [zobraz_mobilni_verzi] => switch to mobile version [paticka_mapa_odkaz] => [nepodporovany_prohlizec] => For full access, please use different browser. [preloader] => Wait a second... [social_in_odkaz] => [social_li_odkaz] => [more_info] => ) [poduzel] => stdClass Object ( [6151] => stdClass Object ( [obsah] => [poduzel] => stdClass Object ( [6154] => stdClass Object ( [obsah] => [iduzel] => 6154 [canonical_url] => //uchpl.vscht.cz [skupina_www] => Array ( ) [url] => [sablona] => stdClass Object ( [class] => [html] => [css] => [js] => [autonomni] => ) ) [6152] => stdClass Object ( [obsah] => [iduzel] => 6152 [canonical_url] => //uchpl.vscht.cz [skupina_www] => Array ( ) [url] => [sablona] => stdClass Object ( [class] => [html] => [css] => [js] => [autonomni] => ) ) [6153] => stdClass Object ( [obsah] => [iduzel] => 6153 [canonical_url] => //uchpl.vscht.cz [skupina_www] => Array ( ) [url] => [sablona] => stdClass Object ( [class] => [html] => [css] => [js] => [autonomni] => ) ) ) [iduzel] => 6151 [canonical_url] => [skupina_www] => Array ( ) [url] => [sablona] => stdClass Object ( [class] => [html] => [css] => [js] => [autonomni] => ) ) [6180] => stdClass Object ( [obsah] => [poduzel] => stdClass Object ( [12485] => stdClass Object ( [nazev] => Studies [seo_title] => Studies [seo_desc] => Studies Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology UCT Prague University of Chemistry and Technology Prague [autor] => [autor_email] => [obsah] =>We offer an undergraduate bachelor degree program as well as a master degree program in the Czech language only. For information about study programs in English, please visit the university's website.
Study with us
We offer the research degree program Doctor of Philosophy (PhD) in Organic Chemistry.
Why study for a PhD at our department?
You will become a member of an internationally recognised research team providing high quality research. You will develop the skills and the knowledge needed to pursue your chosen career—in academia, at research organizations, or in public service.
How to apply?
Our prospective student portal provides details about the application process for PhD programmes at UCT Prague.
Our past graduates
Battaglia Caren Bc. (Master Double Degree)
Abdulmanea Khaled Saleh Omar, MSc., PhD (Yemen): Flavonoids in the Apiaceae family (2012)
Irekhjargal Jambal, MSc., PhD (Mongolia): Inhibitors of galactosyltransferases (2012)
Our present students
Uladzimir Bildziukevich, MSc. (Belarus): Steroid-based compounds with potential pharmacologic importance
Jana Šusteková, Ing. (Slovakia): Self-assembly in supramolecular systems based on steroid compounds
Joint-degree doctoral programme graduates
Ing. Ondřej Jurček, PhD (Czechia): Steroid conjugates for applications in pharmacology and biology (2011), with the Faculty of Mathematics and Science, University of Jyväskylä, Finland
Ing. Helena Heissigerová, PhD (Czechia): Glycosyltransferases: Etude comparative, modelisation moleculaire et synthese de nouveaux inhibiteurs (2003), with the Université Joseph Fourier – Grenoble, France
9 We accept students within the framework of the IAESTE exchange programme.
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We offer our partners:
- synthesis of specialty chemicals from natural compounds and their analogs
- steroids and other terpeniods
- porphyrins
- flavonoids
- saccharides
- glycosides, C-glycosides
- non-isotopic labeled compounds
- prepararion of antibodies, immunogens, tracers and others components of immunoassays
- structural analysis
- quantitative analysis
- consultancy in the development of synhtetic methods
- consultancy in the development of analytical methods
- specialty chemicals and immunochemicals from our libraries
Scientific orientation of the department
- The search for new compounds with novel properties.
- Biologically active compounds are our inspiration.
Research topics
Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, UCT Prague |
k (+420) 220 444 260 |
Technická 5 |
W (+420) 220 444 422 |
166 28 Praha 6 |
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Head of Department |
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Prof. Dr. RNDr. Oldřich Lapčík |
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k (+420) 220 444 448 |
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b Oldrich.Lapcik@vscht.cz |
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room BS18 |
Secretary of Department |
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Secretary |
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assoc. prof. Ing. Kamil Parkan, Ph.D. |
Irena Dražilová |
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k (+420) 220 444 265 |
k (+420) 220 444 260 |
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b Kamil.Parkan@vscht.cz |
b Irena.Drazilova@vscht.cz |
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website |
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CV |
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building A, room A246 |
building A, room A244 |
The Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology at UCT Prague was founded in 1991 as the successor to the Laboratory of Monosaccharides. Its mission includes both education and training at the graduate as well as postgraduate level and research and development in several fields crossing the frontier between organic chemistry and biology.
Our department's research aims to understand living systems at the molecular level, providing new molecules with new properties that eventually could become medicines, among other things. It is essential to continue this research at the fundamental level so as to provide tools for designing, synthesizing, and evaluating new functional molecules for targeting applications. Nature is our inspiration.
Key research areas include:
- Chemistry of steroids and other terpenoids
- Chemistry of supramolecules with chiral natural compounds
- Synthesis of ligands for the cell-cell recognition
- The development of nanosensors for the sensing of pathogenic processes
- Analytical and bioanalytical methods
- Forensic analysis of biologically active compounds
- Chemistry of saccharides and glycomimetics
- Molecular modeling
The study of the chemical background of natural processes is a huge adventure, which we ourselves enjoy and wish to share with others. —Oldrich Lapcik, Department Chair
For further details about our research topics, please visit the webpages of individual teams.
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stdClass Object ( [nazev] => Kamil Parkan [seo_title] => Kamil Parkan [seo_desc] => Kamil Parkan Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology UCT Prague University of Chemistry and Technology Prague [autor] => [autor_email] => [obsah] =>
Researcher ID: F-1138-2017, ORCID ID: 0000-0001-7585-6004 | |
Education |
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2000-2005 |
MSc. study |
Institute of Chemical Technology, Prague (now UCT Prague) |
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Department of Chemistry of Natural Compounds |
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MSc. thesis: Synthesis of polyhydroxylated chiral aldehydes as reactants of aldol reaction |
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Supervisor: Doc. Ing. Ladislav Kniežo, CSc. |
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2005-2010 |
PhD study |
University of Chemistry and Technology, Prague |
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Department of Chemistry of Natural Compounds |
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PhD thesis: Stereoselective synthesis of disaccharides analogues |
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Supervisor: Doc. Ing. Ladislav Kniežo, CSc. |
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2010-2012 |
Postdoctoral fellowship |
Institute of Organic Chemistry and Biochemistry AS CR, Prague |
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Supervisors: Doc. RNDr. Jan Konvalinka, CSc. a prof. RNDr. Martin Kotora, CSc. |
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2021
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habilitation in the field Organic Chemistry |
University of Chemistry and Technology, Prague |
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Habilitation thesis title: Syntéza C-glykosidů a C-disacharidů
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Work position |
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2012 - 2021 |
Department of Chemistry of Natural Compounds, UCT Prague, Assistent professor |
2022 -now |
Associate Professor at the Department of Chemistry of Natural Compounds, UCT Prague |
Teaching |
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Stereoselective synthesis |
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Structure and reactivity |
Bioorganic Chemistry of Natural Compounds
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Bioorganic Chemistry of Carbohydrates and nucleic acids |
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Chemistry of Natural Compounds: Semestral Work |
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Fellowships |
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2004 |
ERASMUS Fellowship |
Chimie des hétérocycles et glucides, Blaise Pascal University, Clermont-Ferrand, Francie |
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Supervisor: Prof. Yves Troin |
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2008 |
PhD Fellowship |
Department of Chemistry and Biochemistry, University of Colorado, Boulder, USA |
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Supervisor: Prof. Josef Michl |
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2010-2012 |
Postdoctoral fellowship |
Institute of Organic Chemistry and Biochemistry AS CR, Prague |
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Supervisors: Doc. RNDr. Jan Konvalinka, CSc. a prof. RNDr. Martin Kotora, CSc. |
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Grants and Projects |
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2022-2024 |
15N isotopic labeling in NMR structural analysis of N-disaccharides |
GAČR, No. 22-17586S; member or research team |
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2018-2022
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Recombinant Biotechnology and Immunotherapy Centre |
Centre, OP - EU Operational Program No. 16_025/0007397_01; member of the research team |
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2017-2021
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Enzymatically stable galectin inhibitors |
Gilead Sciences Research Center; co-PI |
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2015-2017 |
Calix[4]arene/C-oligosaccharide glycocluster design for improved selectivity of interactions with lectins |
GACR No. 15-17572S; member of the research team |
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2012-2014 |
New Pd-catalyzed modular approach to non-hydrolysable vectors for transfection systems |
GACR, No. P207/12/P713, PI |
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2005-2010 |
Ministry of education youth and sports, No. 6046137305. |
2010-2011 |
HIV ACE (Targeting assembly of infectious HIV particles), FP7-HEALTH |
project ref. 201095; member of the research team |
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2008-2010 |
Stereoselective synthesis of disaccharide analogues |
GACR, No. 203/08/1124; member of the research team |
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Řepková Kristýna (2014) | Kratochvíl Michal, (2019) |
Erhartová Lenka (2015) |
Marková Barbora, Bc. (2019) |
Choutka Jan (2015) |
Rahm Michal (2019) |
Nováková Karla (2016) | Vršanová Lucie (2019) |
Beáta Oroszová (Ph.D., 2017) |
Vaňková Karolína (2020) |
Housková Kateřina (2018) |
Battaglia Caren (Master Double Degree, 2020) |
Prouza Vít, (2018) |
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Tóthová Lucia, (2018) |
Řepková Kristýna, Bc. | Synthesis of new analogues of neamine by using of Pd-catalyzed reaction | 2014 |
Erhartová Lenka, Bc. | Preparation of new glycoclusters presenting D-gluco- and D-galactopyranose on calix[4]arene and porphyrine cores by using Pd-catalyzed reaction | 2015 |
Choutka Jan, Bc. | The synthesis of C-disaccharides by using Suzuki-Miyaura reaction | 2015 |
Nováková Karla, Bc. | New synthetic approach for the synthesis of C-glycosides and C-disaccharides | 2016 |
Housková Kateřina, Bc. |
Synthesis of C-disaccharides and biological activity studies with galectins | 2018 |
Prouza Vít, Bc. | S-glycosides: Modular synthesis and biological activity studies | 2018 |
Tóthová Lucia, Bc. |
Saccharides biosensors for detection of bacterial contamination of drinking water | 2018 |
Kratochvíl Michal, Bc. | Synthesis and use of 2-oxyglycals | 2019 |
Marková Barbora, Bc. | Preparation of new glycoclusters by using Pd-catalyzed reaction | 2019 |
Rahm Michal, Bc. |
Ir-catalyzed C-H silylation of glycals |
2019 |
Vršanová Lucie, Bc. | Synthesis of C- and S-glycosides derived from GalNAc | 2019 |
Vaňková Karolína, Bc. | Use of Hiyama reaction for the synthesis of aryl C-glycosides | 2020 |
Battaglia Caren Bc. (Master Double Degree) |
Synthesis of glycomimetics for fluorescence polarization assay with galectins | 2020 |
Mgr. Beáta Oroszová, Ph.D.; | Novel C-disaccharides for the construction of ligands inhibiting interactions between pathogen and cell. | 2017 |
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Employees:
- doc. Ing. Kamil Parkan, Ph.D
- Martina Wimmerová
Ph.D. students:
- Ing. Michal Kratochvíl
- Ing. Jakub Zýka
- Ing. Vít Prouza
- Ing. Jan Choutka
Students:
- Bc. Nikola Kopalová
- Bc. Petra Gwozdiaková
- Bc. Karel Tůma
- Bc. Věra Šemelíková
- Martin Jánský
- Klaudia Hladoníková
- Adam Rybka
- Michal Fischer
- Ondřej Orság
Master Thesis Ph.D. Thesis
2022
Kratochvíl, M.; Cisarová, I.; Pohl, R. ; Kaminský, J; Parkan, K.: Silicon-bridged (1 -> 1)-disaccharides: an umpoled glycomimetic scaffold. Org. Biomol. Chem. 2022, 20, 7613-7621. Online
; Kaminský, J.; Pohl, R.; Miyazaki, T.: Unlocking the Hydrolytic Mechanism of GH92 alpha-1,2-Mannosidases: Computation Inspires the use of C-Glycosides as Michaelis Complex Mimics. Chem.-Eur. J. 2022, 28, e202200148. Online
2021
22. Vaňková, K.; Rahm, M.; Choutka, J.; Pohl, R.; Parkan, K.: Facile Approach to C-glucosides by Using a Protecting-Group-Free Hiyama Cross-Coupling Reaction: High-Yielding Dapagliflozin Synthesis. Chem.-Eur. J., 2021, 27, 10583– 10588. VIP Online
21. Vaňková, K., Šimák, O., Kettelhoit, K., Parkan, K.: One Step Transformation of Glycals into 1-Iodo Glycals. In Carbohydrate Chemistry: Proven Synthetic Methods, Vol 5. Kosma P., Wrodnigg T. M., Stutz A., CRC Press, Taylor & Francis Group:Boca Raton, 2021, Vol. 5, pp 11-16. DOI: 10.1201/9781351256087, ISBN 9780815367888. Online
2020
20. Choutka, J.; Kratochvíl, M.; Zýka, J.; Pohl, R.; Parkan K. Straightforward synthesis of protected 2-hydroxyglycals by chlorination-dehydrochlorination of carbohydrate hemiacetals. Carbohydr. Res. 2020, 496, 108086. Online
2019
19. Faltinek, L.; Fujdiarová, E.; Melicher, F.; Houser, J.; Kašáková, M.; Kondakov, N.; Kononov, L.; Parkan, K.; Vidal, S.; Wimmerová, M. Lectin PLL3, a Novel Monomeric Member of the Seven-Bladed β-Propeller Lectin Family. Molecules 2019, 24, 4540. Online
18. Jančaříková, G.; Houser, J.; Kašáková, M.; Oroszová, B.; Bertolotti, B.; Parkan, K.; Moravcová, J.; Wimmerová, M. Fucosylated inhibitors of recently identified bangle lectin from Photorhabdus asymbiotica. Sci. Rep. 2019, 9, 14904. Online
2018
17. Choutka, J., Pohl, R., Parkan, K.: MOP and EE Protecting Groups in Synthesis of α- or β-Aryl-C-Glycosides from Glycals. ACS Omega 2018, 3, 7875-7887. Online
2017
16. Raich, I.; Lövyová, Z.; Trnka, L.; Parkan, K.; Kessler, J.; Pohl, R.; Kaminský, J. Limitations in the description of conformational preferences of C-disaccharides: The (1 → 3)-C-mannobiose case. Carbohydr. Res. 2017, 451, 42-50. Online
15. Online
2016
14. Bertolotti, B.; Oroszová, B.; Sutkeviciute, I.; Kniežo, L.; Fieschi, F.; Parkan, K.; Lovyová, Z.; Kašáková, M.; Moravcová, J. Nonhydrolyzable C-disaccharides, a new class of DC-SIGN ligands. Carbohydr. Res. 2016, 435, 7-18. Online
13. Kožíšek, M.; Štěpánek, O.; Parkan, K.; Albiñana, B. C.; Pávová, M.; Weber, J.;a, Hans-Georg Krӓusslich, H.-G.; Konvalinka, J.; Machara, A. Synthesis and evaluation of 2-pyridinylpyrimidines as inhibitors of HIV-1 structural protein assembly. Bioorg. Med. Chem. Lett. 2016, 26 , 3487–3490. Online
12. Machara, A.; Lux, V.; Kožíšek, M.; Grantz, Šašková, K.; Štěpánek, O.; Kotora, M.; Parkan, K.; Pávová, M.; Glass, B.; Sehr, P.; Lewis, J.; Mueller, B.; Kraeusslich, H.-G.; Konvalinka J.; Specific inhibitors of HIV capsid assembly binding to the C-terminal domain of the capsid protein: evaluation of 2-arylquinazolines as potential virostatics. J. Med. Chem. 2016, 59, 545-558. Online
2015
11. Šnajdr, I.; Parkan, K.; Hessler, F.; Kotora M. Cross-metathesis Reaction of α- and β-Vinyl C-glycosides with Alkenes. Beilstein J. Org. Chem. 2015, 11, 1392–1397. Online
10. Oroszová, B.; Choutka, J.; Pohl, R.; Parkan, K. Modular Stereoselective Synthesis of (1→2)-C-Glycosides based on the sp2–sp3 Suzuki–Miyaura Reaction. Chem. Eur. J. 2015, 21, 7043-7047. Online
2014
9. Kraeusslich, H.; Sticht, J.; Wildova M.; Lux, V.; Konvalinka J.; Kotora, M.; Grantz, Saskova, K.; Kozisek, M.; Stepanek, O.; Parkan, K.; Machara, A. Use of substituted fused heterocyclic compounds for inhibiting HIV capsid assembly to treat HIV. WO 2014128206-A1, Aug 28, 2014. Online
8. Kraeusslich, H.; Sticht, J.; Wildova M.; Lux, V.; Konvalinka J.; Kotora, M.; Grantz, Saskova, K.; Kozisek, M.; Stepanek, O.; Parkan, K.; Machara, A. 2,4-Substituted or 4,6-substituted pyrimidine compound useful for inhibiting HIV capsid assembly for treating a patient suffering from HIV. WO 2014128213-A1, Aug 28, 2014. Online
7. Kraeusslich, H.; Sticht, J.; Wildova M.; Lux, V.; Konvalinka J.; Kotora, M.; Grantz, Saskova, K.; Kozisek, M.; Stepanek, O.; Parkan, K.; Machara, A. 2,4-Substituted or 4,6-substituted pyrimidine compound useful for inhibiting HIV capsid assembly for treating a patient suffering from HIV. EP 2769722-A1, Aug 27, 2014. Online
6. Kraeusslich, H.; Sticht, J.; Wildova M.; Lux, V.; Konvalinka J.; Kotora, M.; Grantz, Saskova, K.; Kozisek, M.; Stepanek, O.; Parkan, K.; Machara, A. Use of substituted fused heterocyclic compounds for inhibiting HIV capsid assembly to treat HIV. EP 2769723-A1, Aug 27, 2014. Online
5. Parkan, K.; Pohl R.; Kotora, M. Cross-Coupling Reaction of Saccharide-Based Alkenyl Boronic Acids with Aryl Halides: The Synthesis of Bergenin, Chem. Eur. J. 2014, 20, 4414 – 4419. Online
2011
4. Lovyova, Z.; Parkan, K.; Kniezo, L. Stereoselective preparation of four 3-C-mannosylated D- and L-glucals from a single starting compound, Tetrahedron 2011, 67, 4967 – 4979. Online
3. Olive, A.; Parkan, K.; Givelet, C.; Michl, J. Covalent Stabilization: A Sturdy Molecular Square from Reversible Metal-Ion-Directed Self-Assembly, J. Am. Chem. Soc. 2011, 133, 20108 – 20111. Online
2010
2. Parkan, K.; Werner, L.; Lovyova, Z.; Prchalova, E.; Kniezo, L. An approach to stereoselective preparation of 3-C-glycosylated D- and L-glucals. Carbohydr. Res. 2010, 345, 352–362. Online
2008
1. Parkan, K.; Vich, O.; Dvorakova, H.; Kniezo, L. Stereoselective preparation of 2,3-dideoxy-3-C-[(α-D-galactopyranosyl)methyl]-D-arabino-hexopyranose and 2,3-dideoxy-3-C-[(α-D-galactopyranosyl)methyl]-L-arabino-hexopyranose. Collect. Czech. Chem. Commun. 2008, 73, 690–700. Online
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