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Technická 5
166 28 Prague 6 – Dejvice
IČO: 60461337
VAT: CZ60461373

Data mail: sp4j9ch

Copyright: UCT Prague 2015
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We offer an undergraduate bachelor degree program as well as a master degree program in the Czech language only. For information about study programs in English, please visit the university's website.

Study with us

We offer the research degree program Doctor of Philosophy (PhD) in Organic Chemistry.

Why study for a PhD at our department?

You will become a member of an internationally recognised research team providing high quality research. You will develop the skills and the knowledge needed to pursue your chosen career—in academia, at research organizations, or in public service.

How to apply?

Our prospective student portal provides details about the application process for PhD programmes at UCT Prague. 

Our past graduates

Battaglia Caren Bc. (Master Double Degree)

Abdulmanea Khaled Saleh Omar, MSc., PhD (Yemen): Flavonoids in the Apiaceae family (2012)

Irekhjargal Jambal, MSc., PhD (Mongolia): Inhibitors of galactosyltransferases (2012)

Our present students

Uladzimir Bildziukevich, MSc. (Belarus): Steroid-based compounds with potential pharmacologic importance

Jana Šusteková, Ing. (Slovakia): Self-assembly in supramolecular systems based on steroid compounds

Joint-degree doctoral programme graduates

Ing. Ondřej Jurček, PhD (Czechia): Steroid conjugates for applications in pharmacology and biology (2011), with the Faculty of Mathematics and Science, University of Jyväskylä, Finland

Ing. Helena Heissigerová, PhD (Czechia): Glycosyltransferases: Etude comparative, modelisation moleculaire et synthese de nouveaux inhibiteurs (2003), with the Université Joseph Fourier – Grenoble, France

 

9 We accept students within the framework of the IAESTE exchange programme.

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We are open to cooperation on common projects or through contracts.

We offer our partners:

  • synthesis of specialty chemicals from natural compounds and their analogs
    • steroids and other terpeniods
    • porphyrins
    • flavonoids
    • saccharides
    • glycosides, C-glycosides
    • non-isotopic labeled compounds

 

  • prepararion of antibodies, immunogens, tracers and others components of immunoassays
  • structural analysis
  • quantitative analysis
  • consultancy in the development of synhtetic methods
  • consultancy in the development of analytical methods 
  • specialty chemicals and immunochemicals from our libraries

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Scientific orientation of the department 

  • The search for new compounds with novel properties.
  • Biologically active compounds are our inspiration.

Research topics

Chemistry of steroids and other terpenoids

Prof. RNDr. Pavel Drašar, DSc., EurChem, CChem, CSci, FRSC 

Analytical and bioanalytical methods

Prof. Dr. RNDr. Oldřich Lapčík 

Diagnostic and therapeutic nanosystems

RNDr. Miroslav Ledvina, Ph.D.

Chemistry of triterpenoid supramolecules

Prof. Ing. Zdeněk Wimmer, DrSc.

Structural analysis and molecular modeling

Doc. Dr. Ing. Ivan Raich

Laboratory of forensic analysis of biologically active compounds

doc. Ing. Martin Kuchař, Ph.D.

Chemistry of Saccharides and Glycomimetics

doc. Ing. Kamil Parkan, Ph.D.

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Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, UCT Prague  

k (+420) 220 444 260

Technická 5      

W (+420) 220 444 422

166 28 Praha 6

 

 

šířka 215px

Head of Department

 

Prof. Dr. RNDr. Oldřich Lapčík

k (+420) 220 444 448

b Oldrich.Lapcik@vscht.cz

website

CV

room BS18

 ◳ Obrázek1 (jpg) → (originál)

Secretary of Department

šířka 215px

Secretary 

assoc. prof. Ing. Kamil Parkan, Ph.D.

Irena Dražilová

k (+420) 220 444 265

k (+420) 220 444 260

b Kamil.Parkan@vscht.cz

b Irena.Drazilova@vscht.cz

website

 

 CV
building A, room A246

building A, room A244

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The Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology at UCT Prague was founded in 1991 as the successor to the Laboratory of Monosaccharides. Its mission includes both education and training at the graduate as well as postgraduate level and research and development in several fields crossing the frontier between organic chemistry and biology.

Our department's research aims to understand living systems at the molecular level, providing new molecules with new properties that eventually could become medicines, among other things. It is essential to continue this research at the fundamental level so as to provide tools for designing, synthesizing, and evaluating new functional molecules for targeting applications. Nature is our inspiration.

Key research areas include:

  • Chemistry of steroids and other terpenoids
  • Chemistry of supramolecules with chiral natural compounds
  • Synthesis of ligands for the cell-cell recognition
  • The development of nanosensors for the sensing of pathogenic processes
  • Analytical and bioanalytical methods
  • Forensic analysis of biologically active compounds
  • Chemistry of saccharides and glycomimetics
  • Molecular modeling

The study of the chemical background of natural processes is a huge adventure, which we ourselves enjoy and wish to share with others. —Oldrich Lapcik, Department Chair

For further details about our research topics, please visit the webpages of individual teams.

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DATA


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    [nazev] => Kamil Parkan
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 ◳ Obrázek1 (jpg) → (originál)

Researcher ID: F-1138-2017, ORCID ID: 0000-0001-7585-6004

Education

2000-2005

MSc. study

Institute of Chemical Technology, Prague (now UCT Prague)

Department of Chemistry of Natural Compounds

MSc. thesis: Synthesis of polyhydroxylated chiral aldehydes as reactants of aldol reaction 

Supervisor: Doc. Ing. Ladislav Kniežo, CSc.

2005-2010

PhD study

University of Chemistry and Technology, Prague

Department of Chemistry of Natural Compounds

PhD thesis: Stereoselective synthesis of disaccharides analogues

Supervisor: Doc. Ing. Ladislav Kniežo, CSc.

2010-2012

Postdoctoral fellowship

Institute of Organic Chemistry and Biochemistry AS CR, Prague

Supervisors: Doc. RNDr. Jan Konvalinka, CSc. a prof. RNDr. Martin Kotora, CSc.

2021


 


 

habilitation in the field Organic Chemistry

University of Chemistry and Technology, Prague

Habilitation thesis title:

Syntéza C-glykosidů a C-disacharidů

Work position

2012 - 2021

Department of Chemistry of Natural Compounds, UCT Prague, Assistent professor

2022 -now

Associate Professor at the Department of Chemistry of Natural Compounds, UCT Prague

Teaching

 

Stereoselective synthesis 

 

Structure and reactivity

Bioorganic Chemistry of Natural Compounds

Bioorganic Chemistry of Carbohydrates and nucleic acids

Chemistry of Natural Compounds: Semestral Work

Fellowships

2004

ERASMUS Fellowship

Chimie des hétérocycles et glucides, Blaise Pascal University, Clermont-Ferrand, Francie

Supervisor: Prof. Yves Troin

2008

PhD Fellowship

Department of Chemistry and Biochemistry, University of Colorado, Boulder, USA

Supervisor: Prof. Josef Michl

2010-2012

Postdoctoral fellowship

Institute of Organic Chemistry and Biochemistry AS CR, Prague

Supervisors: Doc. RNDr. Jan Konvalinka, CSc. a prof. RNDr. Martin Kotora, CSc.

Grants and Projects

2022-2024

15N isotopic labeling in NMR structural analysis of N-disaccharides

GAČR, No. 22-17586S; member or research team

2018-2022

 

Recombinant Biotechnology and Immunotherapy Centre

Centre, OP - EU Operational Program No. 16_025/0007397_01; member of the research team

2017-2021

 

Enzymatically stable galectin inhibitors

Gilead Sciences Research Center; co-PI

2015-2017

Calix[4]arene/C-oligosaccharide glycocluster design for improved selectivity of interactions with lectins

GACR No. 15-17572S; member of the research team

2012-2014

New Pd-catalyzed modular approach to non-hydrolysable vectors for transfection systems

GACR, No. P207/12/P713, PI

2005-2010

Ministry of education youth and sports, No. 6046137305.

2010-2011

HIV ACE (Targeting assembly of infectious HIV particles), FP7-HEALTH

project ref. 201095; member of the research team

2008-2010

Stereoselective synthesis of disaccharide analogues

GACR, No. 203/08/1124; member of the research team

 

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Řepková Kristýna (2014) Kratochvíl Michal, (2019)
Erhartová Lenka (2015)
Marková Barbora, Bc. (2019)

Choutka Jan (2015)

Rahm Michal (2019)
Nováková Karla (2016) Vršanová Lucie (2019)
Beáta Oroszová (Ph.D., 2017)
Vaňková Karolína (2020)
Housková Kateřina (2018)

Battaglia Caren (Master Double Degree, 2020)

Prouza Vít, (2018)
Tóthová Lucia, (2018)
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Řepková Kristýna, Bc. Synthesis of new analogues of neamine by using of Pd-catalyzed reaction 2014
Erhartová Lenka, Bc. Preparation of new glycoclusters presenting D-gluco- and D-galactopyranose on calix[4]arene and porphyrine cores by using Pd-catalyzed reaction 2015
Choutka Jan, Bc. The synthesis of C-disaccharides by using Suzuki-Miyaura reaction 2015
Nováková Karla, Bc. New synthetic approach for the synthesis of C-glycosides and C-disaccharides 2016
Housková Kateřina, Bc.
Synthesis of C-disaccharides and biological activity studies with galectins 2018
Prouza Vít, Bc. S-glycosides: Modular synthesis and biological activity studies 2018
Tóthová Lucia, Bc.
Saccharides biosensors for detection of bacterial contamination of drinking water 2018
Kratochvíl Michal, Bc. Synthesis and use of 2-oxyglycals 2019
Marková Barbora, Bc. Preparation of new glycoclusters by using Pd-catalyzed reaction 2019
Rahm Michal, Bc.

Ir-catalyzed C-H silylation of glycals

2019
Vršanová Lucie, Bc. Synthesis of C- and S-glycosides derived from GalNAc 2019
Vaňková Karolína, Bc. Use of Hiyama reaction for the synthesis of aryl C-glycosides 2020

Battaglia Caren Bc. 

(Master Double Degree)

Synthesis of glycomimetics for fluorescence polarization assay with galectins 2020
   
   
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Mgr. Beáta Oroszová, Ph.D.; Novel C-disaccharides for the construction of ligands inhibiting interactions between pathogen and cell. 2017

 

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Employees:

Ph.D. students:

  • Ing. Michal Kratochvíl
  • Ing. Jakub Zýka
  • Ing. Vít Prouza
  • Ing. Jan Choutka

Students:

  • Bc. Nikola Kopalová
  • Bc. Petra Gwozdiaková
  • Bc. Karel Tůma
  • Bc. Věra Šemelíková
  • Martin Jánský
  • Klaudia Hladoníková
  • Adam Rybka
  • Michal Fischer
  • Ondřej Orság
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 Master Thesis  Ph.D. Thesis

2022

24. Choutka, J Kratochvíl, M.; Cisarová, I.Pohl, R. Kaminský, J .; Parkan, K.: Silicon-bridged (1 -> 1)-disaccharides: an umpoled glycomimetic scaffold. Org. Biomol. Chem. 2022, 20, 7613-7621. Online

23. Alonso-Gil, S.Parkan, K.Kaminský, J. Pohl, R.Miyazaki, T.: Unlocking the Hydrolytic Mechanism of GH92 alpha-1,2-Mannosidases: Computation Inspires the use of C-Glycosides as Michaelis Complex Mimics. Chem.-Eur. J. 2022, 28, e202200148. Online

2021

22. Vaňková, K.; Rahm, M.; Choutka, J.; Pohl, R.; Parkan, K.: Facile Approach to C-glucosides by Using a Protecting-Group-Free Hiyama Cross-Coupling Reaction: High-Yielding Dapagliflozin Synthesis. Chem.-Eur. J., 2021, 27, 10583– 10588. VIP Online

21. Vaňková, K., Šimák, O., Kettelhoit, K., Parkan, K.: One Step Transformation of Glycals into 1-Iodo Glycals. In Carbohydrate Chemistry: Proven Synthetic Methods, Vol 5. Kosma P., Wrodnigg T. M., Stutz A., CRC Press, Taylor & Francis Group:Boca Raton, 2021, Vol. 5, pp 11-16. DOI: 10.1201/9781351256087, ISBN 9780815367888. Online

2020

20. Choutka, J.; Kratochvíl, M.; Zýka, J.; Pohl, R.; Parkan K. Straightforward synthesis of protected 2-hydroxyglycals by chlorination-dehydrochlorination of carbohydrate hemiacetals. Carbohydr. Res. 2020, 496, 108086. Online

2019

19. Faltinek, L.; Fujdiarová, E.; Melicher, F.; Houser, J.; Kašáková, M.; Kondakov, N.; Kononov, L.; Parkan, K.; Vidal, S.; Wimmerová, M. Lectin PLL3, a Novel Monomeric Member of the Seven-Bladed β-Propeller Lectin Family. Molecules 2019, 24, 4540. Online

18. Jančaříková, G.; Houser, J.; Kašáková, M.; Oroszová, B.; Bertolotti, B.; Parkan, K.; Moravcová, J.; Wimmerová, M. Fucosylated inhibitors of recently identified bangle lectin from Photorhabdus asymbiotica. Sci. Rep. 2019, 9, 14904. Online

2018

17. Choutka, J., Pohl, R., Parkan, K.: MOP and EE Protecting Groups in Synthesis of α- or β-Aryl-C-Glycosides from Glycals. ACS Omega 2018, 3, 7875-7887Online

2017

16. Raich, I.; Lövyová, Z.; Trnka, L.; Parkan, K.; Kessler, J.; Pohl, R.; Kaminský, J. Limitations in the description of conformational preferences of C-disaccharides: The (1 → 3)-C-mannobiose case. Carbohydr. Res. 2017, 451, 42-50.  Online

15. olyvalent C-glycomimetics based on L-fucose or D-mannose as potent DC-SIGN antagonists. Org. Biomol. Chem. 2017, 15, 3995-4004. Online

2016

14. Bertolotti, B.; Oroszová, B.; Sutkeviciute, I.; Kniežo, L.; Fieschi, F.; Parkan, K.; Lovyová, Z.; Kašáková, M.; Moravcová, J. Nonhydrolyzable C-disaccharides, a new class of DC-SIGN ligands. Carbohydr. Res. 2016, 435, 7-18. Online

13. Kožíšek, M.; Štěpánek, O.; Parkan, K.; Albiñana, B. C.;  Pávová, M.; Weber, J.;a, Hans-Georg Krӓusslich, H.-G.; Konvalinka, J.; Machara,  A. Synthesis and evaluation of 2-pyridinylpyrimidines as inhibitors of HIV-1 structural protein assembly. Bioorg. Med. Chem. Lett. 2016, 26 , 3487–3490. Online

12. Machara, A.; Lux, V.; Kožíšek, M.; Grantz, Šašková, K.; Štěpánek, O.; Kotora, M.; Parkan, K.; Pávová, M.; Glass, B.; Sehr, P.; Lewis, J.; Mueller, B.; Kraeusslich, H.-G.; Konvalinka J.; Specific inhibitors of HIV capsid assembly binding to the C-terminal domain of the capsid protein: evaluation of 2-arylquinazolines as potential virostatics. J. Med. Chem. 201659, 545-558. Online

2015

11. Šnajdr, I.; Parkan, K.; Hessler, F.; Kotora M. Cross-metathesis Reaction of α- and β-Vinyl C-glycosides with Alkenes. Beilstein J. Org. Chem. 2015, 11, 1392–1397. Online

10. Oroszová, B.; Choutka, J.; Pohl, R.; Parkan, K. Modular Stereoselective Synthesis of (1→2)-C-Glycosides based on the sp2–sp3 Suzuki–Miyaura Reaction. Chem. Eur. J. 2015, 21, 7043-7047. Online

2014

9. Kraeusslich, H.; Sticht, J.; Wildova M.; Lux, V.; Konvalinka J.; Kotora, M.; Grantz, Saskova, K.; Kozisek, M.; Stepanek, O.; Parkan, K.; Machara, A. Use of substituted fused heterocyclic compounds for inhibiting HIV capsid assembly to treat HIV. WO 2014128206-A1, Aug 28, 2014. Online

8. Kraeusslich, H.; Sticht, J.; Wildova M.; Lux, V.; Konvalinka J.; Kotora, M.; Grantz, Saskova, K.; Kozisek, M.; Stepanek, O.; Parkan, K.; Machara, A. 2,4-Substituted or 4,6-substituted pyrimidine compound useful for inhibiting HIV capsid assembly for treating a patient suffering from HIV. WO 2014128213-A1, Aug 28, 2014. Online

7. Kraeusslich, H.; Sticht, J.; Wildova M.; Lux, V.; Konvalinka J.; Kotora, M.; Grantz, Saskova, K.; Kozisek, M.; Stepanek, O.; Parkan, K.; Machara, A. 2,4-Substituted or 4,6-substituted pyrimidine compound useful for inhibiting HIV capsid assembly for treating a patient suffering from HIV. EP 2769722-A1, Aug 27, 2014. Online

6. Kraeusslich, H.; Sticht, J.; Wildova M.; Lux, V.; Konvalinka J.; Kotora, M.; Grantz, Saskova, K.; Kozisek, M.; Stepanek, O.; Parkan, K.; Machara, A. Use of substituted fused heterocyclic compounds for inhibiting HIV capsid assembly to treat HIV. EP 2769723-A1, Aug 27, 2014. Online

5. Parkan, K.; Pohl R.; Kotora, M. Cross-Coupling Reaction of Saccharide-Based Alkenyl Boronic Acids with Aryl Halides: The Synthesis of Bergenin, Chem. Eur. J. 201420, 4414 – 4419. Online

2011

4. Lovyova, Z.; Parkan, K.; Kniezo, L. Stereoselective preparation of four 3-C-mannosylated D- and L-glucals from a single starting compound, Tetrahedron 2011, 67, 4967 – 4979. Online

3. Olive, A.; Parkan, K.; Givelet, C.; Michl, J. Covalent Stabilization: A Sturdy Molecular Square from Reversible Metal-Ion-Directed Self-Assembly, J. Am. Chem. Soc. 2011, 133, 20108 – 20111. Online

2010

2. Parkan, K.; Werner, L.; Lovyova, Z.; Prchalova, E.; Kniezo, L. An approach to stereoselective preparation of 3-C-glycosylated D- and L-glucals. Carbohydr. Res. 2010345, 352–362. Online

2008

1. Parkan, K.; Vich, O.; Dvorakova, H.; Kniezo, L. Stereoselective preparation of 2,3-dideoxy-3-C-[(α-D-galactopyranosyl)methyl]-D-arabino-hexopyranose and 2,3-dideoxy-3-C-[(α-D-galactopyranosyl)methyl]-L-arabino-hexopyranose.  Collect. Czech. Chem. Commun. 200873, 690–700. Online

 

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