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Technická 5
166 28 Prague 6 – Dejvice
IČO: 60461337
VAT: CZ60461373

Data mail: sp4j9ch

Copyright: UCT Prague 2015
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We offer an undergraduate bachelor degree program as well as a master degree program in the Czech language only. For information about study programs in English, please visit the university's website.

Study with us

We offer the research degree program Doctor of Philosophy (PhD) in Organic Chemistry.

Why study for a PhD at our department?

You will become a member of an internationally recognised research team providing high quality research. You will develop the skills and the knowledge needed to pursue your chosen career—in academia, at research organizations, or in public service.

How to apply?

Our prospective student portal provides details about the application process for PhD programmes at UCT Prague. 

Our past graduates

Battaglia Caren Bc. (Master Double Degree)

Abdulmanea Khaled Saleh Omar, MSc., PhD (Yemen): Flavonoids in the Apiaceae family (2012)

Irekhjargal Jambal, MSc., PhD (Mongolia): Inhibitors of galactosyltransferases (2012)

Our present students

Uladzimir Bildziukevich, MSc. (Belarus): Steroid-based compounds with potential pharmacologic importance

Jana Šusteková, Ing. (Slovakia): Self-assembly in supramolecular systems based on steroid compounds

Joint-degree doctoral programme graduates

Ing. Ondřej Jurček, PhD (Czechia): Steroid conjugates for applications in pharmacology and biology (2011), with the Faculty of Mathematics and Science, University of Jyväskylä, Finland

Ing. Helena Heissigerová, PhD (Czechia): Glycosyltransferases: Etude comparative, modelisation moleculaire et synthese de nouveaux inhibiteurs (2003), with the Université Joseph Fourier – Grenoble, France

 

9 We accept students within the framework of the IAESTE exchange programme.

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We are open to cooperation on common projects or through contracts.

We offer our partners:

  • synthesis of specialty chemicals from natural compounds and their analogs
    • steroids and other terpeniods
    • porphyrins
    • flavonoids
    • saccharides
    • glycosides, C-glycosides
    • non-isotopic labeled compounds

 

  • prepararion of antibodies, immunogens, tracers and others components of immunoassays
  • structural analysis
  • quantitative analysis
  • consultancy in the development of synhtetic methods
  • consultancy in the development of analytical methods 
  • specialty chemicals and immunochemicals from our libraries

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Scientific orientation of the department 

  • The search for new compounds with novel properties.
  • Biologically active compounds are our inspiration.

Research topics

Chemistry of steroids and other terpenoids

Prof. RNDr. Pavel Drašar, DSc., EurChem, CChem, CSci, FRSC 

Analytical and bioanalytical methods

Prof. Dr. RNDr. Oldřich Lapčík 

Diagnostic and therapeutic nanosystems

RNDr. Miroslav Ledvina, Ph.D.

Chemistry of triterpenoid supramolecules

Prof. Ing. Zdeněk Wimmer, DrSc.

Structural analysis and molecular modeling

Doc. Dr. Ing. Ivan Raich

Laboratory of forensic analysis of biologically active compounds

doc. Ing. Martin Kuchař, Ph.D.

Chemistry of Saccharides and Glycomimetics

doc. Ing. Kamil Parkan, Ph.D.

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Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, UCT Prague  

k (+420) 220 444 260

Technická 5      

W (+420) 220 444 422

166 28 Praha 6

 

 

šířka 215px

Head of Department

 

Prof. Dr. RNDr. Oldřich Lapčík

k (+420) 220 444 448

b Oldrich.Lapcik@vscht.cz

website

CV

room BS18

 ◳ Obrázek1 (jpg) → (originál)

Secretary of Department

šířka 215px

Secretary 

assoc. prof. Ing. Kamil Parkan, Ph.D.

Irena Dražilová

k (+420) 220 444 265

k (+420) 220 444 260

b Kamil.Parkan@vscht.cz

b Irena.Drazilova@vscht.cz

website

 

 CV
building A, room A246

building A, room A244

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The Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology at UCT Prague was founded in 1991 as the successor to the Laboratory of Monosaccharides. Its mission includes both education and training at the graduate as well as postgraduate level and research and development in several fields crossing the frontier between organic chemistry and biology.

Our department's research aims to understand living systems at the molecular level, providing new molecules with new properties that eventually could become medicines, among other things. It is essential to continue this research at the fundamental level so as to provide tools for designing, synthesizing, and evaluating new functional molecules for targeting applications. Nature is our inspiration.

Key research areas include:

  • Chemistry of steroids and other terpenoids
  • Chemistry of supramolecules with chiral natural compounds
  • Synthesis of ligands for the cell-cell recognition
  • The development of nanosensors for the sensing of pathogenic processes
  • Analytical and bioanalytical methods
  • Forensic analysis of biologically active compounds
  • Chemistry of saccharides and glycomimetics
  • Molecular modeling

The study of the chemical background of natural processes is a huge adventure, which we ourselves enjoy and wish to share with others. —Oldrich Lapcik, Department Chair

For further details about our research topics, please visit the webpages of individual teams.

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    [seo_desc] => Zdeněk Wimmer Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology UCT Prague University of Chemistry and Technology Prague
    [autor] => 
    [autor_email] => 
    [obsah] => 

Education:

 

1970-1975

Institute of Chemical Technology, Prague (now: UCT Prague), programme Organic chemistry, supervisor prof. Dr. Ing. Miloslav Ferles, DrSc.

1975-1978

PhD studies at the Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, CSc., programme Organic chemistry, supervisor Ing. Miroslav Romaňuk, DrSc.

2001

Scientific degree DSc. awarded by Scientific Council of the Czech Academy of Sciences

2005

Associate professor, appointment at Masaryk University, Brno

2009

Professor, appointment at Masaryk University, Brno

Professional life:

 

1978-1987

Researcher, Section of Natural Compounds, Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences

1987-2006

Senior researcher, Section of Natural Compounds, Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences

2007

Senior researcher, Isotope laboratory of Institute of Experimental Botany, Czech Academy of Sciences (part-time job)

2011

Professor, Department of Chemistry of Natural Compounds, UCT Prague (part-time job)

Teaching:

 

 

Natural compounds as raw materials

 

Raw materials from renewable resources

Professional life:

 

 

Synthesis of biologically and pharmacologically active compounds

 

Supramolecular chemistry focused on utilization of materials from renewable resources

 

Biotechnology in the synthesis of chiral compounds

 

Supercritical extraction of plant materials

Fellowships

 

1982/1983

University Milano, Italy

1992

University Hamburg, Germany

1994-1996

University La Rochelle, France

1996

University Châtenay-Malabry (Paris-Sud), France

 

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  • Bildziukevich U., Rárová L., Janovská L., Šaman D., Wimmer Z.: Enhancing effect of cystamine in its amides with betulinic acid as antimicrobial and antitumor agent in vitro. Steroids 2019, 148, 91-98.
  • Özdemir Z., Bildziukevich U., Wimmerová M., Macůrková A., Lovecká P., Wimmer Z.: Plant adaptogens: Natural Medicaments for 21st century? ChemistrySelect 2018, 3, 2196-2214.
  •  Bildziukevich U., Rárová L., Šaman D., Wimmer Z.: Picolyl amides of betulinic acid as antitumor agents causing tumor cell apoptosis. Eur. J. Med. Chem. 2018, 145, 41-50.
  •  Özdemir Z., Bildziukevich U., Šaman D., Havlíček L., Rárová L., Navrátilová L., Wimmer Z.: Amphiphilic derivatives of (3β,17β)-3-hydroxyandrost-5-ene-17-carboxylic acid. Steroids 2017, 128, 58-67.
  • Škorpilová L., Rimpelová S., Jurášek M., Buděšínský M., Lokajová J., Effenberg R., Slepička P., Ruml T., Kmoníčková E., Drašar P.B., Wimmer Z.: BODIPY-based fluorescent liposomes with seskviterpene lactone trilobolide. Beilstein J. Org. Chem. 2017, 13, 1316-1324.
  • Bildziukevich U., Kaletová E., Šaman D., Sievänen E., Kolehmainen E.T., Šlouf M., Wimmer Z.: Spectral and microscopic study of self-assembly of novel cationic spermine amides of betulinic acid. Steroids 2017, 117, 90-96.
  • Wimmerová M., Siglerová V., Šaman D., Šlouf M., Kaletová E., Wimmer Z.: Improved enzyme-mediated synthesis and supramolecular self-assembly of naturally occurring conjugates of β-sitosterol. Steroids 2017, 117, 38-43.
  • Sperduto C., Smolková M., Jurášek M., Malachowska M., Venanzi M., Monti D., Mancini G., Wimmer Z., Drašar P.: Steroidal ribbons from (3α,5β,20S)-3-hydroxy-20-methyl-pregan-21-oic acid. Lett. Org. Chem. 2016, 13, 711-717.
  • Malachowska M., Sperduto C., Darmostuk M., Monti D., Venanzi M. Mancini G., D’Acunto C.W., Králová J., Ruml T., Wimmer Z., Drašar P.B.: Porphyrins with directly meso-attached disaccharide moieties: Synthesis, self-assembly and cellular study. J. Porphyrin. Phthalocyanin. 2016, 20, 773-784.
  • Bildziukevich U., Vida N., Rárová L., Kolář M., Šaman D., Havlíček L., Drašar P., Wimmer Z.: Polyamine derivatives of betulinic acid and β-sitosterol: A comparative investigation. Steroids 2015, 100, 27-35.
  • Forczek S. T., Laturnus F., Doležalová J., Holík J., Wimmer Z.: Emission of climate relevant volatile organochlorines by plants occurring in temperate forests. Plant Soil Environ. 2015, 61, 103-108.
  • Lapčík O., Wimmer Z., Opletal L., Moravcová J., Čopíková J., Drašar P.: Natural Taste-Sour Substances. Chem. Listy 2015, 109, 488-491.
  • Čopíková J., Wimmer Z., Lapčík O., Cahlíková L., Opletal L., Moravcová J., Drašar P.: Přírodní látky svíravé a trpké chuti. Chem. Listy 2014, 108, 1053-1057.
  • Horník Š., Sajfrtová M., Karban J., Sýkora J., Březinová A., Wimmer Z.: LC-NMR technique in the analysis of phytosterols in natural extracts, Anal. Meth. Chem., 2013, Article ID 526818.
  • Čopíková J., Moravcová J., Wimmer Z., Opletal L., Lapčík O., Drašar P.: Náhradní sladidla, Listy 2013, 107, 867-874.
  • Bildziukevich, Rárová L., Šaman D., Havlíček L., Drašar P., Wimmer Z.: Amides derived from heteroaromatic amines and selected steryl hemiesters, Steroids 2013, 78, 1347-1352.
  • Wimmer Z., Opletal L., Čopíková J., Moravcová J., Abdulmanea K. S. O., Lapčík O., Drašar P.: Kovová chuť přírodních látek a jejich derivátů, Listy 2012, 106, 926-930.
  • Vida N., Svobodová H., Rárová L., Drašar P., Šaman D., Cvačka J., Wimmer Z.: Polyamine conjugates of stigmasterol, Steroids 2012, 77, 1212-1218.
  • Svobodová H., Nonappa, Lahtinen M., Wimmer Z., Kolehmainen E.: A steroid-based gelator of A(LS)2 type: tuning gel properties by metal coordination, Soft Matter 2012, 8, 7840-7847.
  • Jurček O., Lahtinen M., Wimmer Z., Drašar P., Kolehmainen E.: Crystallization, spectral, crystallographical, and thermoanalytical studies of succinobucol polymorphism, Pharm. Sci. 2012, 101, 1794-1802.
  • Ikonen S., Jurček O., Wimmer Z., Drašar P., Kolehmainen E.: Antioxidative succinobucol-sterol conjugates: Crystal structures and pseudosymmetry in the crystals, Mol. Struct. 2012, 1011, 25-33.
  • Zelenka K., Trnka T., Tišlerová I., Monti D., Cinti S., Naitana M. L., Schiaffino M., Venanzi M., Laguzzi G., Luvidi L., Mancini G., Nováková Z., Šimák O., Wimmer Z., Drašar P.: Spectroscopic, morphological, and mechanistic investigation of the solvent-promoted aggregation of porphyrins modified in meso positions by glucosylated steroids, Eur. J. 2011, 17, 13743-13753.
  • Jurček O., Ikonen S., Buřičová L., Wimmerová M., Wimmer Z., Drašar P., Horníček J., Gandaláková A., Ulrichová J., Kolehmainen E. T.: Succinobucol’s new coat – Conjugation with steroids to alter drug effect and bioavailability, Molecules 2011, 16, 9404-9420.
  • Šusteková J., Drašar P., Šaman D., Wimmer Z.: Stigmasterol-based novel low molecular weight / mass organic gelators, Molecules 2011, 16, 9357-9367.
  • Opletal L., Wimmer Z., Čopíková J., Lapčík O., Moravcová J., Cahlíková L., Drašar P.: Slaná chuť přírodních látek a jejich derivátů, Listy 2011, 105, 761-765.
  • Brabcová J., Hanus R., Tykva R., Vlasáková V., Černý B., Wimmer Z., Zarevúcka M.: Degradation of juvenogens by termites and soil bacteria, Biochem. Physiol. 2011, 101, 103-108.
  • Svobodová H., Nonappa, Wimmer Z., Kolehmainen E.: Design, synthesis and stimuli responsive gelation of novel stigmasterol-amino acid conjugates, Colloid Interf. Sci. 2011, 361, 587-593.
  • Stránský K., Valterová I., Kofroňová E., Urbanová K., Zarevúcka M., Wimmer Z.: Non-polar lipid components of human cerumen, Lipids 2011, 46, 781-788.
  • Štěpánek P., Šimák O., Nováková Z., Wimmer Z., Drašar P.: Asymmetrically substituted calix[4]pyrrole with chiral substituents, Biomol. Chem. 2011, 6, 682-683.
  • Svobodová H., Ryšavá H., Pavlík M., Šaman D., Wimmer Z.: Steroid conjugates: Synthesis and preliminary biological testing of pro-juvenoids, Med. Chem. 2010, 18, 8194-8203.
  • Pavlík M., Ryšavá H., Wimmer Z.: Metabolism of insect ecdysteroids and significance of insect intestinal microbiota, Listy 2010, 104, 831-837.
  • Ryšavá H., Štursa P., Kurzawová V., Pavlík M., Wimmer Z., Macková M., Ryšánek P.: Identifikace kultivovatelných střevních bakterií ruměnice pospolné (Pyrrhocoris apterus). Sborník recenzovaných příspěvků kategorie Věda má budoucnost (Maršálek R., Ed.), Přírodovědecká fakulta, Ostravská universita v Ostravě, 2010, pp. 62-65. ISBN: 978-80-7368-719-9.
  • Sajfrtová M., Ličková I., Wimmerová M., Sovová H., Wimmer Z.: b-Sitosterol: Supercritical carbon dioxide extraction from sea buckthorn (Hippophae rhamnoides) seeds, Int. J. Mol. Sci. 2010, 11, 1842-1850.
  • Wimmer Z., Zarevúcka M.: A review on the effect of supercritical carbon dioxide on enzyme activity, J. Mol. Sci. 2010, 11, 233-253.
  • Šobotník J., Hanus R., Piskorski R., Urbanová K., Wimmer Z., Weyda F., Vytisková B., Sillam-Dussès D.: Impact of a juvenile hormone analogue on the anatomy and the frontal gland secretion of Prorhinotermes simplex (Isoptera: Rhinotermitidae), Insect Physiol. 2010, 56, 65-72.
  • Ryšavá H., Pavlík M., Wimmer Z., Jurček O., Svobodová H., Ryšánek P.: Biologická účinnost nových typů analogů juvenilních hormonů testovaných na ruměnici pospolné (Pyrrhocoris apterus). Aktuální poznatky v pěstování, šlechtění, ochraně rostlin a zpracování produktů. Výzkumný ústav pícninářský, spol. s r.o. Troubsko. Úroda 2009, 209-212. ISSN: 0139-6013.
  • Jurček O., Wimmer Z., Bennettová B., Moravcová J., Drašar P., Šaman D.: Novel juvenogens (insect hormonogenic agents): Preparation and biological tests on Neobellieria bullata, Agric. Food Chem. 2009, 57, 10852-10858.
  • Hlavsová K., Zarevúcka M., Wimmer Z., Macková M., Sovová H.: Geotrichum candidum 4013: Extracellular lipase versus cell-bound lipase from the single strain, Mol. Catal. B: Enzym. 2009, 61, 188-193.
  • Jurček O., Wimmer Z., Svobodová H., Bennettová B., Kolehmainen E., Drašar P.: Preparation and preliminary biological screening of cholic acid–juvenoid conjugates, Steroids 2009, 74, 779-785.
  • Zarevúcka M., Wimmer Z.: Chapter IV: Application of lipases to substances with pharmacological importance (polyunsaturated fatty acids). In: Biocatalysis Research Progress (Romano H. F., Russo A., Eds.), 2008, pp. 155-185. ISBN: 978-1-60456-619-2.
  • Zarevúcka M., Wimmer Z.: Plant products for pharmacology: Application of enzymes in their transformations, J. Mol. Sci. 2008, 9, 2447-2473.
  • Novák J., Tykva R., Wimmer Z., Pavlík M., Prouza M., Hlavsová K., Zarevúcka M.: Enantiomeric purity of biodegradation products of juvenogens by newly isolated soil bacteria, Agric. Food Chem. 2008, 56, 6604-6608.
  • Hlavsová K., Wimmer Z., Xanthakis E., Bernášek P., Sovová H., Zarevúcka M.: Lipase activity enhancement by SC-CO2 treatment, Naturforsch. B 2008, 63, 779-784.
  • Tykva R., Černý B., Wimmer Z., Hanus R.: Distribution of a juvenogen and its metabolites in a laboratory system during juvenogen-induced caste differentiation in a termite Reticulitermes santonensis (Isoptera: Rhinotermitidae). Pest Sci. 2008, 64, 654-659.
  • Jurček O., Wimmerová M., Wimmer Z.: Selected chiral alcohols: Enzymic resolution and reduction of convenient substrates, Chem. Rev. 2008, 252, 767-781.
  • Wimmer Z., Pechová L., Sīle L., Šaman D., Jedlička P., Wimmerová M., Kolehmainen E.: Glycosidic juvenogens: Derivatives bearing a,b-unsaturated ester functionalities, Med. Chem. 2007, 15, 7126-7137.
  • Jedlička P., Hrdý I., Kuldová J., Wimmer Z.: The systemic effects of juvenoids on the red firebug Pyrrhocoris apterus and on the pea aphid Acyrthosiphon pisum with data on life table response, Pest Sci. 2007, 63, 1026-1035.
  • Wimmer Z., Jurček O., Jedlička P., Hanus R., Kuldová J., Hrdý I., Bennettová B., Šaman D.: Insect pest management agents: Hormonogen esters (juvenogens), Agric. Food Chem. 2007, 55, 7387-7393.
  • Wimmer Z., Floro A. J. F. D. M., Zarevúcka M., Wimmerová M., Sello G., Orsini F.: Insect pest control agents: Novel chiral butanoate esters (juvenogens), Med. Chem. 2007, 15, 6037-6042.
  • Stránský K., Zarevúcka M., Kejík Z., Wimmer Z., Macková M., Demnerová K.: Substrate specificity, regioselectivity and hydrolytic activity of lipases activated from Geotrichum sp., Eng. J. 2007, 34, 209-216.
  • Xanthakis E., Zarevúcka M., Šaman D., Wimmerová M., Kolisis F. N., Wimmer Z.: Application of ionic liquids in enzymic resolution by hydrolysis of cycloalkyl acetates, Tetrahedron: Asym. 2006, 17, 2987-2992.
  • Šaman D., Kratina P., Moravcová J., Wimmerová M., Wimmer Z.: Synthesis and structure assignment of 2-(4-methoxybenzyl)cyclohexyl b-d-glucopyranoside enantiomers, Czech. Chem. Commun. 2006, 71, 1470-1483.
  • Stránský K., Zarevúcka M., Valterová I., Wimmer Z.: Gas chromatographic retention data of wax esters, Chromatogr. A, 2006, 1128, 208-219.
  • Šaman D., Wimmerová M., Wimmer Z.: Synthesis and structure assignment of 2-(4-methoxybenzyl)cyclohexyl b-d-galactopyranoside stereoisomers, Czech. Chem. Commun. 2006, 71, 1186-1198.
  • Hrdý, Kuldová J., Hanus R., Wimmer Z.: Juvenile hormone III, hydroprene and a juvenogen as soldier caste differentiation regulators in three Reticulitermes species: potential of JHAs in termite control. Pest Manag. Sci. 2006, 62, 848-854.
  • Wimmer Z., Kuldová J., Hrdý I., Bennettová B.: Can juvenogens, biochemically targeted hormonogen compounds, assist in environmentally safe insect pest management? Insect Biochem. Mol. Biol. 2006, 36, 442-453.

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