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Technická 5
166 28 Prague 6 – Dejvice
IČO: 60461337
VAT: CZ60461373

Data mail: sp4j9ch

Copyright: UCT Prague 2015
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We offer an undergraduate bachelor degree program as well as a master degree program in the Czech language only. For information about study programs in English, please visit the university's website.

Study with us

We offer the research degree program Doctor of Philosophy (PhD) in Organic Chemistry.

Why study for a PhD at our department?

You will become a member of an internationally recognised research team providing high quality research. You will develop the skills and the knowledge needed to pursue your chosen career—in academia, at research organizations, or in public service.

How to apply?

Our prospective student portal provides details about the application process for PhD programmes at UCT Prague. 

Our past graduates

Battaglia Caren Bc. (Master Double Degree)

Abdulmanea Khaled Saleh Omar, MSc., PhD (Yemen): Flavonoids in the Apiaceae family (2012)

Irekhjargal Jambal, MSc., PhD (Mongolia): Inhibitors of galactosyltransferases (2012)

Our present students

Uladzimir Bildziukevich, MSc. (Belarus): Steroid-based compounds with potential pharmacologic importance

Jana Šusteková, Ing. (Slovakia): Self-assembly in supramolecular systems based on steroid compounds

Joint-degree doctoral programme graduates

Ing. Ondřej Jurček, PhD (Czechia): Steroid conjugates for applications in pharmacology and biology (2011), with the Faculty of Mathematics and Science, University of Jyväskylä, Finland

Ing. Helena Heissigerová, PhD (Czechia): Glycosyltransferases: Etude comparative, modelisation moleculaire et synthese de nouveaux inhibiteurs (2003), with the Université Joseph Fourier – Grenoble, France

 

9 We accept students within the framework of the IAESTE exchange programme.

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We are open to cooperation on common projects or through contracts.

We offer our partners:

  • synthesis of specialty chemicals from natural compounds and their analogs
    • steroids and other terpeniods
    • porphyrins
    • flavonoids
    • saccharides
    • glycosides, C-glycosides
    • non-isotopic labeled compounds

 

  • prepararion of antibodies, immunogens, tracers and others components of immunoassays
  • structural analysis
  • quantitative analysis
  • consultancy in the development of synhtetic methods
  • consultancy in the development of analytical methods 
  • specialty chemicals and immunochemicals from our libraries

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Scientific orientation of the department 

  • The search for new compounds with novel properties.
  • Biologically active compounds are our inspiration.

Research topics

Chemistry of steroids and other terpenoids

Prof. RNDr. Pavel Drašar, DSc., EurChem, CChem, CSci, FRSC 

Analytical and bioanalytical methods

Prof. Dr. RNDr. Oldřich Lapčík 

Diagnostic and therapeutic nanosystems

RNDr. Miroslav Ledvina, Ph.D.

Chemistry of triterpenoid supramolecules

Prof. Ing. Zdeněk Wimmer, DrSc.

Structural analysis and molecular modeling

Doc. Dr. Ing. Ivan Raich

Laboratory of forensic analysis of biologically active compounds

doc. Ing. Martin Kuchař, Ph.D.

Chemistry of Saccharides and Glycomimetics

doc. Ing. Kamil Parkan, Ph.D.

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Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, UCT Prague  

k (+420) 220 444 260

Technická 5      

W (+420) 220 444 422

166 28 Praha 6

 

 

šířka 215px

Head of Department

 

Prof. Dr. RNDr. Oldřich Lapčík

k (+420) 220 444 448

b Oldrich.Lapcik@vscht.cz

website

CV

room BS18

 ◳ Obrázek1 (jpg) → (originál)

Secretary of Department

šířka 215px

Secretary 

assoc. prof. Ing. Kamil Parkan, Ph.D.

Irena Dražilová

k (+420) 220 444 265

k (+420) 220 444 260

b Kamil.Parkan@vscht.cz

b Irena.Drazilova@vscht.cz

website

 

 CV
building A, room A246

building A, room A244

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The Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology at UCT Prague was founded in 1991 as the successor to the Laboratory of Monosaccharides. Its mission includes both education and training at the graduate as well as postgraduate level and research and development in several fields crossing the frontier between organic chemistry and biology.

Our department's research aims to understand living systems at the molecular level, providing new molecules with new properties that eventually could become medicines, among other things. It is essential to continue this research at the fundamental level so as to provide tools for designing, synthesizing, and evaluating new functional molecules for targeting applications. Nature is our inspiration.

Key research areas include:

  • Chemistry of steroids and other terpenoids
  • Chemistry of supramolecules with chiral natural compounds
  • Synthesis of ligands for the cell-cell recognition
  • The development of nanosensors for the sensing of pathogenic processes
  • Analytical and bioanalytical methods
  • Forensic analysis of biologically active compounds
  • Chemistry of saccharides and glycomimetics
  • Molecular modeling

The study of the chemical background of natural processes is a huge adventure, which we ourselves enjoy and wish to share with others. —Oldrich Lapcik, Department Chair

For further details about our research topics, please visit the webpages of individual teams.

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DATA


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    [nazev] => Oldřich Lapčík
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    [seo_desc] => Oldřich Lapčík Department of Chemistry of Natural Compounds at the Faculty of Food and Biochemical Technology UCT Prague University of Chemistry and Technology Prague
    [autor] => 
    [autor_email] => 
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Education

 

1984 – 1989

Charles University Prague, Faculty of Science, programme Biochemistry

1993 – 1998

Doctoral study at the Department of Biochemistry, Charles University Prague, programme Biochemistry, PhD thesis „Radioimmunoassay of Isoflavonoid Phytoestrogens“, supervisor prof. RNDr. Richard Hampl, DrSc.

Employment

 

1980 – 1982

General University Hospital Prague, Hemodialysis Center Strahov, hospital attendant

1982 – 1984

Military service

1984 – 1989

General University Hospital Prague, Hemodialysis Center Strahov,, hospital attendant (part-time job while studying)

1989 – 2001

Institute of Endocrinology, Prague

2002 –

Department of Chemistry of Natural Compounds, UCT Prague, assistant professor (2002-6), associate professor (2006-9), professor (since 2009)

2007 –

Department of Chemistry of Natural Compounds, UCT Prague, head of the department

Teaching

 

 

Plant-based theraputics and traditional medicine

 

Bioactive Natural Compounds

 

Professional interest

 

 

Biologically active natural compounds and their analogues (steroids, terpenoids, flavonoids and polyphenols)

 

Imunoanalytical and instrumental methods for the determination of low-molecular compounds

 

Application of developed methods in phytochemistry, endocrinology and forensic science

Fellowships

 

1992

Department of Physiology, University of Turku, Finland

1993

Institut fur Biochemische Endokrinologie, Medizinische Universitet, Lubeck, Germany

1993

Department of Clinical Chemistry, University of Helsinki, Finsko

1996

Huddinge University Hospital, Karolinska Institute, Huddinge, Sweden

1998

Department of Physiology, University of Turku, Finland

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Mikšátková P., Ancheeva E., Hejtmánková K., Teslov L., Lapčík O. (2014) Determination of Flavonoids in Stellaria by High-Performance Liquid Chromatography–Tandem Mass Spectrometry. Analytical Letters, 47: 2317–2331.

Mikšátková P., Lanková P., Huml L., Lapčík O. (2014) Isoflavonoids in the Amaryllidaceae family. Nat. Prod. Res. 28 (10), 690-697.

Pičmanová M, Reňák D, Pleskot R, Feciková J, Mikšátková P, Lapčík O, Honys D (2013) Polymorphic protein CYP93C18 is responsible for the endoplasmic reticulum membrane-associated isoflavone synthase activity in pea. Biologia Palntarum 57 (4), 635-645.

Leuner O., Havlik J., Budešínský M., Vrkoslav V., Chu J., Bradshaw T. D., Hummelová J., Mikšátková P., Lapčík O., Valterová I., Kokoška L. (2013) Cytotoxic constituents in Pachyrhizus tuberosus from Peruvian Amazon. Nat. Prod. Commun. 8 (10), 1423-1426.

Holubová B., Goselová S., Ševčíková L., Vlach M., Blažková M., Lapčík O., Fukal L. (2013) Rapid Immunoassays for Detection of Anabolic Nortestosterone in Dietary Supplements. Czech J. Food Sci 31 (5), 514-519.

Abdulmanea K., Prokudina E.A., Lanková P., Vaníčková L., Koblovská R., Zelený V., Lapčík O. (2012) Immunochemical and HPLC identification of isoflavonoids in the Apiaceae family. Biochem. Syst. Ecol. 45, 237–243.

Prokudina E.A., Havlíček L., Al-Maharik N., Lapčík O., Strnad M., Gruz J. (2012) Rapid UPLC–ESI–MS/MS method for the analysis of isoflavonoids and other phenylpropanoids. J Food Comp. Anal. 26(1-2), 36-42.

Sosvorová L., Mikšátková P., Bičíková M., Kaňová N., Lapčík O. (2012) The presence of monoiodinated derivates of daidzein and genistein in human urine and its effect on thyroid gland function. Food Chem. Toxicol. 50(8) 2774-2779.

Prokudina E.A., Lanková P., Koblovská R., Al-Maharik N., Lapčík O. (2011) Development of sorbents for immunoaffinity extraction of isoflavonoids. Phytochem. Lett. 4, 113–117.

Sosvorová L., Lanková L., Bičíková M., Prokudina E.A., Al-Maharik N., Lapčík O. (2011) ELISA for Free S-equol in Human Urine. Czech J. Food Sci, 29: 65-72.

Hampl R. Ostatníková D., Celec P., Putz Z., Lapčík O., Matucha P. (2008) Short-term effect of soy consumption on thyroid hormone levels and correlation with phytoestrogen level in healthy subjects. Endocr Regul. 4(2):53-61.

Koblovská R., Macková Z., Vítková M., Kokoška L., Klejdus B., Lapčík O. (2008) Isoflavones in the Rutaceae family: Twenty selected representatives of the genera Citrus, Fortunella, Poncirus, Ruta and Severinia. Phytochem. Analysis 19: 64-70.

Klejdus B., Vacek J., Benešová L., Kopecký J., Lapčík O., Kubáň V. (2007) Rapid-resolution HPLC with spectrophotometric detection for determination and identification of isoflavones in soy preparations and plant extracts. Anal. Bioanal. Chem. 389: 2277–2285.

Zamrazilová L., Kazihnitková H., Lapčík O., Hill M., Hampl R. (2007) A Novel Radioimmunoassay of 16α-Hydroxy-Dehydroepiandrosterone and its Physiological levels. J. Steroid Biochem. Molec. Biol. 104: 130-135.

Včeláková H., Hill M., Lapčík O., Pařízek A. (2007) Determination of 17α-hydroxypregnenolone sulfate and its application in diagnostics. Steroids, 72: 323-327.

Kazihnitková H., Zamrazilová L., Hill M., Lapčík O., Pouzar V. Hampl R. (2007)     A novel radioimmunoassay of 7-OXO-DHEA and its physiological levels. Steroids, 72: 342-350

Milerová J., Čeřovská J, Zamrazil V., Bílek R., Lapčík O., Hampl R. (2006) Actual levels of soy phytoestrogens correlate with thyroid laboratory parameters. Clin. Chem. Lab. Med. 44: 171-174.

Lapčík O., Honys D., Koblovská R., Macková Z., Vítková M., Klejdus B. (2006) Isoflavonoids are present in Arabidopsis thaliana despite the absence of any homologue to known isoflavonoid synthases. Plant Physiol. Biochem 44: 106-114.         

Klejdus B., Lojková L., Lapčík O., Koblovská R., Moravcová J., Kubáň V. (2005) Supercritical fluid extraction of isoflavones from biological samples with ultra-fast high-performance liquid chromatography/mass spectrometry. J. Sep. Sci. 28: 1334–1346.  

Lapčík O., Klejdus B., Kokoška L., Davidová M., Afandi K., Kubáň V., Hampl R. (2005) Identification of isoflavones in Acca sellowiana and two Psidium species (Myrtaceae) Biochem. Syst. Ecol. 33: 983-992.

Lapčík O., Vítková M, Klejdus B., Al-Maharik N., Adlercreutz H. (2004) Immunoassay for biochanin A. J. Immunol. Methods 294: 155-163.

Lapčík O., Klejdus B., Davidová M., Kokoška L., Kubáň V., Moravcová J. (2004) Isoflavonoids in the Rutaceae family: 1. Fortunella obovata, Murraya paniculata and four Citrus species. Phytochem. Analysis 9: 293-299.      

Lapčík O., Štursa J., Kleinová T., Vítková M., Dvořáková H., Klejdus B., Moravcová J. (2003) Synthesis of hapten and conjugates of coumestrol and development of immunoassay. Steroids 68: 1147-1155.    

Brouwers E., L´Homme R., Al-Maharik N., Lapčík O., Hampl R., Wahala K., Mikola H., Adlercreutz H. (2003) Time-resolved fluoroimmunoassay for equol in plasma and urine. J. Steroid Biochem. Molec. Biol. 84: 577-588.  

Pouzar V., Černý I., Lapčík O., Hill M., Hampl R. (2003) Synthesis of two new haptens of 16 alpha – hydroxydehydroepiandrosterone (3 beta, 16 alpha- dihydroxyandrost-5en-17-one). Steroids 68: 149-158.  

Hill M., Pařízek A., Klak J., Hampl R., Šulcová J., Havlíková H., Lapčík O., Bičíková M., Fait T., Kantcheva R. Cibula D., Pouzar V., Meloun M., Stárka L. (2002) Neuroactive steroids, their precursors and polar conjugates during parturition and postpartum in maternal and umbilical blood: 3,3b-hydroxy-5-ene steroids. J. Steroid Biochem. Molec. Biol. 82: 241-250.    

L´homme R., Brouwers E., Al-Maharik N., Lapčík O., Hampl R., Mikola H., Wähälä K., Adlercreutz H. (2002) Time-resolved fluoroimmunoassay of plasma and urine     O-desmethylangolensin. J. Steroid Biochem. Molec. Biol. 81: 353-361.                      

Hill M., Lapčík O., Havlíková H., Morfin R., Hampl R. (2001) 7-Hydroxy-dehydroepiandrosterone epimers in human serum and saliva: Comparison of gass chromatography-mass spectrometry and radioimmunoassay. J. Chromatography A. 935: 297-307.  

Uehara M., Lapčík O., Hampl R., Al-Maharik N., Makala T., Wähälä K., Mikola H., Adlercreutz H. (2000) Rapid analysis of phytoestrogens in human urine by time-resolved fluoroimmunoassay. J. Steroid Biochem. Molec. Biol. 72: 273-282.              

Wang G.J., Lapčík O., Hampl R., Uehara M., Al-Maharik N., Stumpf K., Mikola H., Wähälä K., Adlercreutz H. (2000) Time-resolved fluoroimmunoassay of plasma daidzein and genistein. Steroids 65: 339-348.      

Lapčík O., Hampl R., Hill M., Stárka L. (1999): Immunoassay of 7-hydroxysteroids:             2. Radioimmunoassay of 7a-hydroxy-dehydroepiandrosterone. J. Steroid Biochem. Molec. Biol. 71: 231-237.    

Lapčík O., Hill M., Černý I., Lachman J., Al-Maharik N., Adlercreutz H., Hampl. R. (1999) Immunoanalysis of isoflavonoids in Pisum sativum and Vigna radiata. Plant Science 148: 111-119.    

Hill M., Lukáč D., Lapčík O., Šulcová J., Hampl R., Pouzar V., Stárka L. (1999) Age Relationships and Sex Differences in Serum Levels of Pregnenolone and 17-Hydroxypregnenolone in Healthy Subjects. Clin. Chem. Lab. Med. 37: 439-447.

Hampl R., Lapčík O., Hill M., Bičíková M., Putz Z., Vaňuga A., Stárka L. (1999) Dehydroepiandrosterone and its 7-hydroxylated metabolites in Hashimoto´s thyroiditis (a preliminary report). The Thyroid Gland 1, 1999, 11-14      

Hill M., Hampl R., Lukáč D., Lapčík O., Pouzar V., Šulcová J. (1999) Elimination of cross-reactivity by addition of an excess of crossreactant for radioimmunoassay of 17a-hydroxypregnenolone. Steroids 64: 341-355.      

Adlercreutz H., Wang G.J., Lapčík O., Hampl R., Wähälä K., Mäkelä T., Lusa K., Talme M., Mikola H. (1998) Time resolved fluoroimmunoassay for plasma enterolactone. Anal. Biochem. 265: 208-215.    

Lapčík O., Hampl R., Hill M., Bičíková M., Stárka L. (1998) Immunoassay of 7-hydroxysteroids: 1. Radioimmunoassay of 7b-Hydroxy Dehydroepiandrosterone.     J. Steroid Biochem. Molec. Biol. 67: 439-445.    

Lapčík O., Hill M., Hampl R., Wähälä K. , Al-Maharik N. and Adlercreutz H. (1998) Radioimmunoassay of free genistein in human serum J. Steroid Biochem. Molec. Biol. 64: 261-268.    

Lapčík O., Hill M., Hampl R., Wähälä K. and Adlercreutz H. (1998) Identification of isoflavonoids in beer. Steroids 63: 14-20.    

Lapčík O., Hampl R., Al-Maharik N., Salakka A., Wähälä K., Adlercreutz H. (1997) A novel radioimmunoassay for daidzein. Steroids 62:315-320.

Hill M., Lapčík O.and Hampl R. (1997) Evaluation and separation of steroid-bovine serum albumin conjugates by high-performance liquid chromatography. J. Chromatography B, 691: 187-191.  

Stárka L., Hampl R., Hill M., Lapčík O., Bílek R., Petřik R. (1997) Epitestosterone in Human Blood and Prostatic Tissue. Eur. J. Clin. Chem. Clin. Biochem 35, 469-473.  

Hill M., Lapčík O., Hampl R., Stárka L.and Putz Z. (1995) Radioimmunoassay of three deoxycorticoids in human plasma following HPLC separation. Steroids 60: 615-620.  

Lapčík O. , Hampl R., Hill M. and Stárka L. (1995) Plasma levels of epitestosterone from prepuberty to adult life. J. Steroid Biochem. Molec. Biol. 55: 405-408.              

Behre H., Hampl R., Lapčík O., Hill M. and Stárka L. (1995) The effect of epitestosterone on spermatogenesis in rats. Endocrine regulations 29: 195-199.        

Bičíková M., Lapčík O., Hampl R., Stárka L., Knuppen R., Haupt O. and Dibbelt L. (1995) A novel radioimmunoassay of allopregnanolone. Steroids 60: 210-213.          

Lapčík O., Perheentupa A., Bičíková M., Huhtaniemi I. and Hampl R. (1994) The effect of epitestosterone on gonadotropin synthesis and secretion. J. Endocrinol. 143: 353-358.        

Hampl R., Lapčík O., Šulcová J., Stárka L., Kalvachová B., Dvořáková M., Němcová D. and Hoza J. (1994) The effect of long-term glucocorticoid therapy on glucocorticoid receptor content an steroid response on ACTH, J. Steroid Biochem Molec Biol 48 (1): 81-87.  

Bičíková M., Kančeva R., Lapčík O. and Stárka L. (1993) The effect of epitestosterone on the plasma levels of LH and FSH in ovariectomized immature rats. J. Steroid Biochem. Molec. Biol. 45: 321-324 (1993) .

Sulková S., Votruba T., Lapčík O. (1990) Beta-2-microglobulin serum levels during dialysis: effect of cuprophan and serum osmolality changes. Int. J. Artif. Org., 13(1): 22-25.

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